Metabolic rewiring controlled by c-Fos governs cartilage integrity in osteoarthritis.
Arthritis, Experimental
Chondrocytes
Osteoarthritis
Journal
Annals of the rheumatic diseases
ISSN: 1468-2060
Titre abrégé: Ann Rheum Dis
Pays: England
ID NLM: 0372355
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
received:
09
02
2023
accepted:
11
05
2023
medline:
14
8
2023
pubmed:
22
6
2023
entrez:
21
6
2023
Statut:
ppublish
Résumé
The activator protein-1 (AP-1) transcription factor component c-Fos regulates chondrocyte proliferation and differentiation, but its involvement in osteoarthritis (OA) has not been functionally assessed. c-Fos expression was evaluated by immunohistochemistry on articular cartilage sections from patients with OA and mice subjected to the destabilisation of the medial meniscus (DMM) model of OA. Cartilage-specific c-Fos knockout (c-Fos FOS-positive chondrocytes were increased in human and murine OA cartilage during disease progression. Compared with c-Fos c-Fos modulates cellular bioenergetics in chondrocytes by balancing pyruvate flux between anaerobic glycolysis and the tricarboxylic acid cycle in response to OA signals. We identify a novel metabolic adaptation of chondrocytes controlled by c-Fos-containing AP-1 dimers that could be therapeutically relevant.
Identifiants
pubmed: 37344157
pii: ard-2023-224002
doi: 10.1136/ard-2023-224002
pmc: PMC10423482
doi:
Substances chimiques
Collagen
9007-34-5
Transcription Factor AP-1
0
FOS protein, human
0
Fos protein, mouse
0
Proto-Oncogene Proteins c-fos
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1227-1239Informations de copyright
© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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