Synthesis of New Chromene Derivatives Targeting Triple-Negative Breast Cancer Cells.

apoptosis chromenes microtubules mitotic slippage multinucleation senescence

Journal

Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829

Informations de publication

Date de publication:
09 May 2023
Historique:
received: 01 03 2023
revised: 10 04 2023
accepted: 06 05 2023
medline: 22 6 2023
pubmed: 22 6 2023
entrez: 22 6 2023
Statut: epublish

Résumé

Breast cancer continues to be the leading cause of cancer-related deaths among women worldwide. The most aggressive type of breast cancer is triple-negative breast cancer (TNBC). Indeed, not only does TNBC not respond well to several chemotherapeutic agents, but it also frequently develops resistance to various anti-cancer drugs, including taxane mitotic inhibitors. This necessitates the search for newer, more efficacious drugs. In this study, we synthesized two novel chromene derivatives (

Identifiants

pubmed: 37345018
pii: cancers15102682
doi: 10.3390/cancers15102682
pmc: PMC10216081
pii:
doi:

Types de publication

Journal Article

Langues

eng

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Auteurs

Aysha Alneyadi (A)

Department of Biology, College of Science, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates.

Zohra Nausheen Nizami (ZN)

Department of Biology, College of Science, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates.

Hanan E Aburawi (HE)

Department of Biology, College of Science, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates.

Soleiman Hisaindee (S)

Department of Chemistry, College of Science, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates.

Muhammad Nawaz (M)

Department of Nano-Medicine Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia.

Samir Attoub (S)

Department of Pharmacology & Therapeutics, College of Medicine & Health Sciences, United Arab Emirates University, Al-Ain P.O. Box 15551, United Arab Emirates.

Gaber Ramadan (G)

Department of Biology, College of Science, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates.

Nehla Benhalilou (N)

Department of Biology, College of Science, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates.

Mazoun Al Azzani (M)

Department of Biology, College of Science, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates.

Yassine Elmahi (Y)

Department of Biology, College of Science, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates.

Aysha Almeqbali (A)

Department of Biology, College of Science, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates.

Khalid Muhammad (K)

Department of Biology, College of Science, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates.

Ali H Eid (AH)

Department of Basic Medical Sciences, College of Medicine, QU Health, Qatar University, Doha P.O. Box 2713, Qatar.

Ranjit Vijayan (R)

Department of Biology, College of Science, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates.

Rabah Iratni (R)

Department of Biology, College of Science, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates.

Classifications MeSH