A theoretical study of H
diffusion model
hydrogen peroxide
minibeam radiation therapy
spatial fractionation
Journal
Medical physics
ISSN: 2473-4209
Titre abrégé: Med Phys
Pays: United States
ID NLM: 0425746
Informations de publication
Date de publication:
Aug 2023
Aug 2023
Historique:
revised:
16
05
2023
received:
21
11
2022
accepted:
09
06
2023
medline:
15
8
2023
pubmed:
22
6
2023
entrez:
22
6
2023
Statut:
ppublish
Résumé
Minibeam radiation therapy (MBRT) is an innovative dose delivery method with the potential to spare normal tissue while achieving similar tumor control as conventional radiotherapy. However, it is difficult to use a single dose parameter, such as mean dose, to compare different patterns of MBRT due to the spatially fractionated radiation. Also, the mechanism leading to the biological effects is still unknown. This study aims to demonstrate that the hydrogen peroxide (H A free diffusion model (FDM) for H Compared with a previous Monte Carlo & Convolution method, this analytical method provides more accurate results. Furthermore, the new model shows H DMCR is a more realistic model for H
Sections du résumé
BACKGROUND
BACKGROUND
Minibeam radiation therapy (MBRT) is an innovative dose delivery method with the potential to spare normal tissue while achieving similar tumor control as conventional radiotherapy. However, it is difficult to use a single dose parameter, such as mean dose, to compare different patterns of MBRT due to the spatially fractionated radiation. Also, the mechanism leading to the biological effects is still unknown.
PURPOSE
OBJECTIVE
This study aims to demonstrate that the hydrogen peroxide (H
METHODS
METHODS
A free diffusion model (FDM) for H
RESULTS
RESULTS
Compared with a previous Monte Carlo & Convolution method, this analytical method provides more accurate results. Furthermore, the new model shows H
CONCLUSION
CONCLUSIONS
DMCR is a more realistic model for H
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
5262-5272Subventions
Organisme : Deutscher Akademischer Austauschdienst (DAAD)
ID : 57450037
Informations de copyright
© 2023 The Authors. Medical Physics published by Wiley Periodicals LLC on behalf of American Association of Physicists in Medicine.
Références
Bertho A, Ortiz R, Juchaux M, et al. First evaluation of temporal and spatial fractionation in proton Minibeam radiation therapy of glioma-bearing rats. Cancers (Basel). 2021;13(19):4865.
Prezado Y, Jouvion G, Guardiola C, et al. Tumor control in RG2 glioma-bearing rats: a comparison between proton Minibeam therapy and standard proton therapy. Int J Radiat Oncol Biol Phys. 2019;104(2):266-271.
Prezado Y, Jouvion G, Patriarca A, et al. Proton minibeam radiation therapy widens the therapeutic index for high-grade gliomas. Sci Rep. 2018;8(1):16479.
Sammer M, Dombrowsky AC, Schauer J, et al. Normal tissue response of combined temporal and spatial fractionation in proton Minibeam radiation therapy. Int J Radiat Oncol Biol Phys. 2021;109(1):76-83.
Dombrowsky AC, Schauer J, Sammer M, et al. Acute skin damage and late radiation-induced fibrosis and inflammation in murine ears after high-dose irradiation. Cancers (Basel). 2019;11(5):727.
Le Caër S, Water radiolysis: influence of oxide surfaces on H2 production under ionizing radiation. Water. 2011;3(1):235-253.
Dal Bello R, Becher T, Fuss MC, Krämer M, Seco J. Proposal of a chemical mechanism for mini-beam and micro-beam efficacy. Front Phys. 2020;8:564836.
Ballarini F, Biaggi M, Merzagora M, et al. Stochastic aspects and uncertainties in the prechemical and chemical stages of electron tracks in liquid water: a quantitative analysis based on Monte Carlo simulations. Radiat Environ Biophys. 2000;39(3):179-188.
Boscolo D, Kramer M, Durante M, Fuss MC, Scifoni E. TRAX-CHEM: a pre-chemical and chemical stage extension of the particle track structure code TRAX in water targets. Chem Phys Lett. 2018;698:11-18.
Meesungnoen J, Jay-Gerin J. Radiation chemistry of liquid water with heavy ions: Monte Carlo simulation studies. Charged Particle and Photon Interactions with Matter: Recent Advances, Applications, and Interfaces. Taylor & Francis; 2011:355-400.
Ramos-Mendez J, Perl J, Schuemann J, McNamara A, Paganetti H, Faddegon B. Monte Carlo simulation of chemistry following radiolysis with TOPAS-nBio. Phys Med Biol. 2018;63(10):105014.
Karamitros M, Luan S, Bernal MA, et al. Diffusion-controlled reactions modeling in Geant4-DNA. J Comput Phys. 2014;274:841-882.
Plante I. A review of simulation codes and approaches for radiation chemistry. Phys Med Biol. 2021;66(3):03TR02.
Tian Z, Jiang SB, Jia X. Accelerated Monte Carlo simulation on the chemical stage in water radiolysis using GPU. Phys Med Biol. 2017;62(8):3081-3096.
Gülden M, Jess A, Kammann J, Maser E, Seibert H. Cytotoxic potency of H2O2 in cell cultures: impact of cell concentration and exposure time. Free Radical Biol Med. 2010;49(8):1298-1305.
McClelland RE, Dennis R, Reid LM, Stegemann JP, Palsson B, Macdonald JM. Chapter 6 - Tissue Engineering. In: Enderle JD, Bronzino JD, eds. Introduction to Biomedical Engineering (Third Edition). Academic Press; 2012:273-357.
Bouchet A, Brauer-Krisch E, Prezado Y, et al. Better efficacy of synchrotron spatially microfractionated radiation therapy than uniform radiation therapy on glioma. Int J Radiat Oncol Biol Phys. 2016;95(5):1485-1494.
Regnard P, Le Duc G, Brauer-Krisch E, et al. Irradiation of intracerebral 9L gliosarcoma by a single array of microplanar x-ray beams from a synchrotron: balance between curing and sparing. Phys Med Biol. 2008;53(4):861-878.
Rivera JN, Kierski TM, Kasoji SK, Abrantes AS, Dayton PA, Chang SX. Conventional dose rate spatially-fractionated radiation therapy (SFRT) treatment response and its association with dosimetric parameters: a preclinical study in a Fischer 344 rat model. PLoS One. 2020;15(6):e0229053.
Romano M, Bravin A, Mittone A, et al. A multi-scale and multi-technique approach for the characterization of the effects of spatially fractionated X-ray radiation therapies in a preclinical model. Cancers (Basel). 2021;13(19):4953.
Serduc R, Bouchet A, Brauer-Krisch E, et al. Synchrotron microbeam radiation therapy for rat brain tumor palliation-influence of the microbeam width at constant valley dose. Phys Med Biol. 2009;54(21):6711-6724.
Uyama A, Kondoh T, Nariyama N, et al. A narrow microbeam is more effective for tumor growth suppression than a wide microbeam: an in vivo study using implanted human glioma cells. J Synchrotron Radiat. 2011;18(4):671-678.
Kacem H, Psoroulas S, Boivin G, et al. Comparing radiolytic production of H(2)O(2) and development of Zebrafish embryos after ultra high dose rate exposure with electron and transmission proton beams. Radiother Oncol. 2022;175:197-202.
Dahm-Daphi J, Sass C, Alberti W. Comparison of biological effects of DNA damage induced by ionizing radiation and hydrogen peroxide in CHO cells. Int J Radiat Biol. 2000;76(1):67-75.
Ogawa Y. Paradigm shift in radiation biology/radiation oncology-exploitation of the “H2O2 effect” for radiotherapy using low-LET (linear energy transfer) radiation such as X-rays and high-energy electrons. Cancers. 2016;8(3):28.
Park WH. Hydrogen peroxide inhibits the growth of lung cancer cells via the induction of cell death and G1-phase arrest. Oncol Rep. 2018;40(3):1787-1794.
Aw TY. Cellular redox: a modulator of intestinal epithelial cell proliferation. News Physiol Sci. 2003;18(5):201-204.
Jones DP. Redox potential of GSH/GSSG couple: assay and biological significance. In: Sies H, Packer L, eds. Methods in Enzymology. Academic Press; 2002:93-112.
Bertho A, Iturri L, Brisebard E, et al. Evaluation of the role of the immune system response after Minibeam radiation therapy. Int J Radiat Oncol Biol Phys. 2023;115(2):426-439.
Herrera-Ortiz A, Martinez-Barnetche J, Smit N, Rodriguez MH, Lanz-Mendoza H. The effect of nitric oxide and hydrogen peroxide in the activation of the systemic immune response of Anopheles albimanus infected with Plasmodium berghei. Dev Comp Immunol. 2011;35(1):44-50.
Reth M. Hydrogen peroxide as second messenger in lymphocyte activation. Nat Immunol. 2002;3(12):1129-1134.