The yeast transcription factor Stb5 acts as a negative regulator of autophagy by modulating cellular metabolism.
Ald6
NADPH
Ymr315w
Zwf1
autophagosome
pentose phosphate pathway
Journal
Autophagy
ISSN: 1554-8635
Titre abrégé: Autophagy
Pays: United States
ID NLM: 101265188
Informations de publication
Date de publication:
10 2023
10 2023
Historique:
pmc-release:
02
07
2024
medline:
4
9
2023
pubmed:
22
6
2023
entrez:
22
6
2023
Statut:
ppublish
Résumé
Macroautophagy/autophagy is a highly conserved pathway of cellular degradation and recycling that maintains cell health during homeostatic conditions and facilitates survival during stress. Aberrant cellular autophagy contributes to the pathogenesis of human diseases such as cancer, neurodegeneration, and cardiovascular, metabolic and lysosomal storage disorders. Despite decades of research, there remain unanswered questions as to how autophagy modulates cellular metabolism, and, conversely, how cellular metabolism affects autophagy activity. Here, we have identified the yeast metabolic transcription factor Stb5 as a negative regulator of autophagy. Chromosomal deletion of
Identifiants
pubmed: 37345792
doi: 10.1080/15548627.2023.2228533
pmc: PMC10472870
doi:
Substances chimiques
NADP
53-59-8
Transcription Factors
0
Stb5 protein, S cerevisiae
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
2719-2732Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM131919
Pays : United States
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