Complex Regulation of Gamma-Hemolysin Expression Impacts Staphylococcus aureus Virulence.
Staphylococcus aureus
gamma-hemolysin CB
mRNA translation
pneumonia
rabbit model
toxin regulation
Journal
Microbiology spectrum
ISSN: 2165-0497
Titre abrégé: Microbiol Spectr
Pays: United States
ID NLM: 101634614
Informations de publication
Date de publication:
17 08 2023
17 08 2023
Historique:
medline:
21
8
2023
pubmed:
22
6
2023
entrez:
22
6
2023
Statut:
ppublish
Résumé
Staphylococcus aureus gamma-hemolysin CB (HlgCB) is a core-genome-encoded pore-forming toxin that targets the C5a receptor, similar to the phage-encoded Panton-Valentine leucocidin (PVL). Absolute quantification by mass spectrometry of HlgCB in 39 community-acquired pneumonia (CAP) isolates showed considerable variations in the HlgC and HlgB yields between isolates. Moreover, although HlgC and HlgB are encoded on a single operon, their levels were dissociated in 10% of the clinical strains studied. To decipher the molecular basis for the variation in
Identifiants
pubmed: 37347186
doi: 10.1128/spectrum.01073-23
pmc: PMC10434192
doi:
Substances chimiques
Leukocidins
0
Hemolysin Proteins
0
Exotoxins
0
Virulence Factors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0107323Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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