Effects of daily artificial gravity training on orthostatic tolerance following 60-day strict head-down tilt bedrest.
Artificial gravity
Bedrest
Cardiovascular deconditioning
Orthostatic tolerance
Journal
Clinical autonomic research : official journal of the Clinical Autonomic Research Society
ISSN: 1619-1560
Titre abrégé: Clin Auton Res
Pays: Germany
ID NLM: 9106549
Informations de publication
Date de publication:
08 2023
08 2023
Historique:
received:
01
03
2023
accepted:
26
05
2023
medline:
21
8
2023
pubmed:
22
6
2023
entrez:
22
6
2023
Statut:
ppublish
Résumé
Orthostatic intolerance commonly occurs following immobilization or space flight. We hypothesized that daily artificial gravity training through short-arm centrifugation could help to maintain orthostatic tolerance following head-down tilt bedrest, which is an established terrestrial model for weightlessness. We studied 24 healthy persons (eight women; age 33.3 ± 9.0 years; BMI 24.3 ± 2.1 kg/m Compared with baseline measurements, supine and upright heart rate increased in all three groups following head-down tilt bedrest. Compared with baseline measurements, time to presyncope decreased by 323 ± 235 s with continuous centrifugation, by 296 ± 508 s with intermittent centrifugation, and by 801 ± 354 s in the control group (p = 0.0249 between interventions). The change in orthostatic tolerance was not correlated with changes in plasma volume. Daily artificial gravity training on a short-arm centrifuge attenuated the reduction in orthostatic tolerance after 60 days of head-down tilt bedrest.
Identifiants
pubmed: 37347452
doi: 10.1007/s10286-023-00959-5
pii: 10.1007/s10286-023-00959-5
pmc: PMC10439060
doi:
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
401-410Informations de copyright
© 2023. The Author(s).
Références
PLoS One. 2020 Sep 18;15(9):e0239228
pubmed: 32946482
J Appl Physiol (1985). 2015 Jan 1;118(1):29-35
pubmed: 25342708
Front Physiol. 2015 Jan 12;5:521
pubmed: 25628571
Anal Chem. 2020 Jul 7;92(13):9072-9078
pubmed: 32484659
J Appl Physiol (1985). 1996 Jul;81(1):7-18
pubmed: 8828642
Am J Med Sci. 2007 Jul;334(1):80-5
pubmed: 17630598
Aviat Space Environ Med. 2002 Jun;73(6):532-6
pubmed: 12056667
Eur J Prev Cardiol. 2022 Aug 5;29(10):1399-1411
pubmed: 35148376
Aerosp Med Hum Perform. 2015 Dec;86(12 Suppl):A54-A67
pubmed: 26630196
Clin Auton Res. 2022 Dec;32(6):423-430
pubmed: 36195683
Environ Med. 1999 Dec;43(2):150-2
pubmed: 11762388
ESC Heart Fail. 2021 Feb;8(1):729-744
pubmed: 33191629
J Appl Physiol (1985). 2001 Aug;91(2):645-53
pubmed: 11457776
J Musculoskelet Neuronal Interact. 2016 Jun 07;16(2):84-91
pubmed: 27282452
Circulation. 2002 Nov 26;106(22):2806-11
pubmed: 12451007
J Appl Physiol (1985). 2002 Feb;92(2):586-94
pubmed: 11796668
Hypertension. 2000 Dec;36(6):E3-4
pubmed: 11116134
PLoS One. 2015 May 28;10(5):e0125780
pubmed: 26020542
J Appl Physiol (1985). 2016 Jul 1;121(1):348-9
pubmed: 26917693
NPJ Microgravity. 2020 Feb 7;6:7
pubmed: 32047839
J Appl Physiol (1985). 2016 Apr 15;120(8):891-903
pubmed: 26893033
Auton Neurosci. 2022 Jan;237:102906
pubmed: 34823150
Eur J Appl Physiol. 2004 Jul;92(3):235-48
pubmed: 15156322
Hypertension. 2005 Mar;45(3):391-8
pubmed: 15699447
Med Sci Sports Exerc. 2018 Sep;50(9):1961-1980
pubmed: 29620686
Front Physiol. 2021 Jan 13;11:612188
pubmed: 33519517
J Physiol. 2002 Jan 1;538(Pt 1):321-9
pubmed: 11773339
Eur J Appl Physiol. 2012 Feb;112(2):605-16
pubmed: 21626041
Circulation. 2019 Aug 27;140(9):729-738
pubmed: 31319685
J Physiol. 2002 Jan 1;538(Pt 1):331-40
pubmed: 11773340
Am J Clin Nutr. 2022 Nov;116(5):1430-1440
pubmed: 36026525
J Appl Physiol (1985). 2010 May;108(5):1177-86
pubmed: 20223994
Front Physiol. 2022 Sep 08;13:976926
pubmed: 36160844
J Appl Physiol (1985). 1995 Mar;78(3):1023-9
pubmed: 7775294
Neurol Sci. 2022 May;43(5):3039-3051
pubmed: 35194757
Front Physiol. 2021 Feb 11;12:614619
pubmed: 33643065
Front Physiol. 2018 Jul 06;9:716
pubmed: 30034341
J Appl Physiol (1985). 2012 May;112(10):1735-43
pubmed: 22345434
AJNR Am J Neuroradiol. 2015 Nov;36(11):2048-54
pubmed: 26185326
Biomed Res Int. 2015;2015:896372
pubmed: 26425559
Hypertension. 2004 Apr;43(4):809-13
pubmed: 14981050
Clin Auton Res. 1994 Apr;4(1-2):41-7
pubmed: 8054836
Front Neurol. 2021 Mar 26;12:648958
pubmed: 33841315