Broad-Spectrum Small-Molecule Inhibitors Targeting the SAM-Binding Site of Flavivirus NS5 Methyltransferase.
NS5
broad spectrum
flaviviruses
high throughput screening
methyltransferase
Journal
ACS infectious diseases
ISSN: 2373-8227
Titre abrégé: ACS Infect Dis
Pays: United States
ID NLM: 101654580
Informations de publication
Date de publication:
14 07 2023
14 07 2023
Historique:
pmc-release:
14
07
2024
medline:
17
7
2023
pubmed:
22
6
2023
entrez:
22
6
2023
Statut:
ppublish
Résumé
Flavivirus infections, such as those caused by dengue virus (DENV), West Nile virus (WNV), yellow fever virus (YFV), and Zika virus (ZIKV), pose a rising threat to global health. There are no FDA-approved drugs for flaviviruses, although a small number of flaviviruses have vaccines. For flaviviruses or unknown viruses that may appear in the future, it is particularly desirable to identify broad-spectrum inhibitors. The NS5 protein is regarded as one of the most promising flavivirus drug targets because it is conserved across flaviviruses. In this study, we used FL-NAH, a fluorescent analog of the methyl donor
Identifiants
pubmed: 37348028
doi: 10.1021/acsinfecdis.2c00571
pmc: PMC10436986
mid: NIHMS1915247
doi:
Substances chimiques
Methyltransferases
EC 2.1.1.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1319-1333Subventions
Organisme : NIAID NIH HHS
ID : R21 AI158176
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI161845
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI140406
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI175435
Pays : United States
Organisme : NIAID NIH HHS
ID : R56 AI131669
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI131669
Pays : United States
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