Input density tunes Kenyon cell sensory responses in the Drosophila mushroom body.
Drosophila melangaster
Marr-Albus theory
brain engineering
development
expansion layer
mushroom body
neural network
olfaction
pattern separation
Journal
Current biology : CB
ISSN: 1879-0445
Titre abrégé: Curr Biol
Pays: England
ID NLM: 9107782
Informations de publication
Date de publication:
10 07 2023
10 07 2023
Historique:
received:
05
02
2023
revised:
02
05
2023
accepted:
26
05
2023
pmc-release:
10
07
2024
medline:
13
7
2023
pubmed:
23
6
2023
entrez:
22
6
2023
Statut:
ppublish
Résumé
The ability to discriminate sensory stimuli with overlapping features is thought to arise in brain structures called expansion layers, where neurons carrying information about sensory features make combinatorial connections onto a much larger set of cells. For 50 years, expansion coding has been a prime topic of theoretical neuroscience, which seeks to explain how quantitative parameters of the expansion circuit influence sensory sensitivity, discrimination, and generalization. Here, we investigate the developmental events that produce the quantitative parameters of the arthropod expansion layer, called the mushroom body. Using Drosophila melanogaster as a model, we employ genetic and chemical tools to engineer changes to circuit development. These allow us to produce living animals with hypothesis-driven variations on natural expansion layer wiring parameters. We then test the functional and behavioral consequences. By altering the number of expansion layer neurons (Kenyon cells) and their dendritic complexity, we find that input density, but not cell number, tunes neuronal odor selectivity. Simple odor discrimination behavior is maintained when the Kenyon cell number is reduced and augmented by Kenyon cell number expansion. Animals with increased input density to each Kenyon cell show increased overlap in Kenyon cell odor responses and become worse at odor discrimination tasks.
Identifiants
pubmed: 37348501
pii: S0960-9822(23)00736-4
doi: 10.1016/j.cub.2023.05.064
pmc: PMC10529417
mid: NIHMS1912453
pii:
doi:
Substances chimiques
Drosophila Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2742-2760.e12Subventions
Organisme : NIDCD NIH HHS
ID : R01 DC018032
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH110932
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Informations de copyright
Copyright © 2023 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.
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