Hypoxia induced responses are reflected in the stromal proteome of breast cancer.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
22 06 2023
22 06 2023
Historique:
received:
02
12
2021
accepted:
07
06
2023
medline:
26
6
2023
pubmed:
23
6
2023
entrez:
22
6
2023
Statut:
epublish
Résumé
Cancers are often associated with hypoxia and metabolic reprogramming, resulting in enhanced tumor progression. Here, we aim to study breast cancer hypoxia responses, focusing on secreted proteins from low-grade (luminal-like) and high-grade (basal-like) cell lines before and after hypoxia. We examine the overlap between proteomics data from secretome analysis and laser microdissected human breast cancer stroma, and we identify a 33-protein stromal-based hypoxia profile (33P) capturing differences between luminal-like and basal-like tumors. The 33P signature is associated with metabolic differences and other adaptations following hypoxia. We observe that mRNA values for 33P predict patient survival independently of molecular subtypes and basic prognostic factors, also among low-grade luminal-like tumors. We find a significant prognostic interaction between 33P and radiation therapy.
Identifiants
pubmed: 37349288
doi: 10.1038/s41467-023-39287-7
pii: 10.1038/s41467-023-39287-7
pmc: PMC10287711
doi:
Substances chimiques
Proteome
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3724Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM132129
Pays : United States
Informations de copyright
© 2023. The Author(s).
Références
Cancer Res. 2012 Oct 15;72(20):5285-95
pubmed: 22890239
Breast Cancer Res Treat. 2010 Oct;123(3):725-31
pubmed: 20020197
Trends Mol Med. 2012 Sep;18(9):534-43
pubmed: 22921864
Nat Biotechnol. 2019 Jul;37(7):773-782
pubmed: 31061481
Cancer Immunol Res. 2016 Jul;4(7):600-10
pubmed: 27197066
Nat Methods. 2020 Sep;17(9):869-870
pubmed: 32669682
Nature. 2019 May;569(7757):503-508
pubmed: 31068700
Nat Methods. 2017 May;14(5):513-520
pubmed: 28394336
J Gen Physiol. 1927 Mar 7;8(6):519-30
pubmed: 19872213
Mol Endocrinol. 2011 Feb;25(2):199-211
pubmed: 20861225
N Engl J Med. 2004 Dec 30;351(27):2817-26
pubmed: 15591335
Oncotarget. 2015 Apr 30;6(12):10634-45
pubmed: 25860936
Proteomics. 2014 Jun;14(12):1494-502
pubmed: 24729417
J Natl Cancer Inst. 2011 Feb 2;103(3):264-72
pubmed: 21191116
J Vis Exp. 2013 Sep 02;(79):
pubmed: 24022122
Mol Cancer Ther. 2005 Oct;4(10):1465-74
pubmed: 16227395
PLoS One. 2014 Nov 06;9(11):e112121
pubmed: 25375149
Nucleic Acids Res. 2013 Jan;41(Database issue):D1063-9
pubmed: 23203882
Cancer Cell. 2018 Jul 9;34(1):21-43
pubmed: 29731393
Int J Nanomedicine. 2018 Oct 04;13:6049-6058
pubmed: 30323592
Nat Biotechnol. 2014 Mar;32(3):223-6
pubmed: 24727771
Curr Cancer Drug Targets. 2018;18(6):538-557
pubmed: 28969555
Br J Cancer. 2015 Jan 20;112(2):382-90
pubmed: 25461803
Cancer Res. 2006 Nov 1;66(21):10292-301
pubmed: 17079448
Science. 2016 Apr 8;352(6282):175-80
pubmed: 27124451
Cell Death Discov. 2020 Aug 18;6:77
pubmed: 32864165
Oncogene. 2003 Oct 16;22(46):7155-69
pubmed: 14562044
Ann Oncol. 2013 Sep;24(9):2206-23
pubmed: 23917950
Cell. 1996 Aug 9;86(3):353-64
pubmed: 8756718
Int J Mol Sci. 2019 Mar 15;20(6):
pubmed: 30875872
Trends Biochem Sci. 2016 Mar;41(3):211-218
pubmed: 26778478
Front Cell Dev Biol. 2018 Feb 20;6:18
pubmed: 29515996
Sci Signal. 2019 Nov 26;12(609):
pubmed: 31772123
Bioinformatics. 2001 Apr;17(4):369-70
pubmed: 11301307
J Cancer. 2017 Sep 12;8(16):3131-3141
pubmed: 29158785
Sci Rep. 2021 Feb 25;11(1):4691
pubmed: 33633150
Clin Cancer Res. 2013 Sep 1;19(17):4879-88
pubmed: 23820108
Nature. 2000 Aug 17;406(6797):747-52
pubmed: 10963602
Proteomics Clin Appl. 2014 Jun;8(5-6):427-37
pubmed: 24677670
Cell. 2017 Nov 30;171(6):1437-1452.e17
pubmed: 29195078
Nat Biotechnol. 2008 Dec;26(12):1367-72
pubmed: 19029910
Breast Cancer Res Treat. 2012 Jun;133(2):501-10
pubmed: 21947750
Nature. 2011 May 19;473(7347):298-307
pubmed: 21593862
Nat Med. 2009 Aug;15(8):907-13
pubmed: 19648928
Nat Methods. 2007 Nov;4(11):923-5
pubmed: 17952086
Cell. 2017 Aug 10;170(4):605-635
pubmed: 28802037
Breast Cancer Res. 2001;3(5):313-7
pubmed: 11597320
Front Oncol. 2021 Feb 23;11:559822
pubmed: 33708620
Bioinformatics. 2016 Sep 15;32(18):2847-9
pubmed: 27207943
Genome Res. 2003 Nov;13(11):2498-504
pubmed: 14597658
J Clin Oncol. 2009 Mar 10;27(8):1160-7
pubmed: 19204204
PLoS One. 2009 Jul 03;4(7):e6146
pubmed: 19582160
Cell. 2010 Jan 8;140(1):62-73
pubmed: 20074520
Ann N Y Acad Sci. 2015 Jun;1346(1):33-44
pubmed: 25907074
Ann Oncol. 2014 Jun;25(6):1122-7
pubmed: 24669015
Breast Cancer Res Treat. 2013 Nov;142(2):237-55
pubmed: 24162158
Nature. 2015 Jun 4;522(7554):106-110
pubmed: 26017313
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50
pubmed: 16199517
Proteomics. 2005 Aug;5(13):3531-6
pubmed: 16041672
Breast. 2013 Jun;22(3):282-8
pubmed: 22840462
Nucleic Acids Res. 2014 Jan;42(Database issue):D959-65
pubmed: 24304897
Breast Cancer Res. 2011 Aug 12;13(4):215
pubmed: 21884641
Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10869-74
pubmed: 11553815
Nat Rev Clin Oncol. 2012 Dec;9(12):674-87
pubmed: 23149893
Sci Rep. 2020 Feb 19;10(1):2914
pubmed: 32076022
Mol Cell Proteomics. 2021;20:100077
pubmed: 33813065
Cancer Cell. 2006 Dec;10(6):515-27
pubmed: 17157791
Cancer J. 2015 Jul-Aug;21(4):267-73
pubmed: 26222078
Nat Commun. 2019 Oct 24;10(1):4862
pubmed: 31649238
Sci Rep. 2017 Apr 24;7(1):1089
pubmed: 28439082
Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5116-21
pubmed: 11309499
PLoS Comput Biol. 2011 Oct;7(10):e1002240
pubmed: 22028643
Cancer Res. 2018 Oct 15;78(20):6001-6010
pubmed: 30154156
J Clin Invest. 2022 Jun 1;132(11):
pubmed: 35642641
J Biomed Sci. 2022 Aug 5;29(1):56
pubmed: 35927755
Nucleic Acids Res. 2019 Jan 8;47(D1):D419-D426
pubmed: 30407594
Cell. 2020 Jan 23;180(2):387-402.e16
pubmed: 31978347
Genome Biol. 2013 Apr 29;14(4):R34
pubmed: 23618380
BMC Bioinformatics. 2003 Jan 13;4:2
pubmed: 12525261
Mol Biol Rep. 2022 Nov;49(11):10961-10973
pubmed: 36057753
Nature. 1992 Oct 29;359(6398):843-5
pubmed: 1279431
Nucleic Acids Res. 2017 Jan 4;45(D1):D362-D368
pubmed: 27924014
Nat Methods. 2016 Sep;13(9):731-40
pubmed: 27348712
BMC Med. 2009 Mar 16;7:9
pubmed: 19291283
Trends Mol Med. 2011 Nov;17(11):641-9
pubmed: 21764377
Nat Methods. 2015 Mar;12(3):211-4, 3 p following 214
pubmed: 25581801
Pathol Res Pract. 2010 Apr 15;206(4):223-8
pubmed: 20097481
Trends Cancer. 2016 Dec;2(12):758-770
pubmed: 28741521
J Clin Invest. 2011 Jul;121(7):2750-67
pubmed: 21633166
Nat Commun. 2022 Feb 16;13(1):896
pubmed: 35173148
Cell. 2013 Jul 3;154(1):61-74
pubmed: 23827675
Breast Cancer Res Treat. 2011 Dec;130(3):1063-71
pubmed: 21874512
PLoS One. 2012;7(11):e49529
pubmed: 23185353
Science. 2006 Sep 29;313(5795):1929-35
pubmed: 17008526
Nature. 2012 Apr 18;486(7403):346-52
pubmed: 22522925