No time to lose: the current state of research in rapid-acting psychotherapeutics.
Journal
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
ISSN: 1740-634X
Titre abrégé: Neuropsychopharmacology
Pays: England
ID NLM: 8904907
Informations de publication
Date de publication:
Jan 2024
Jan 2024
Historique:
received:
23
03
2023
accepted:
31
05
2023
revised:
08
05
2023
pmc-release:
01
01
2025
medline:
11
12
2023
pubmed:
23
6
2023
entrez:
22
6
2023
Statut:
ppublish
Résumé
The vast majority of treatments for psychiatric and substance use disorders take weeks to work. Notable exceptions to this rule exist, with some treatments such as intravenous ketamine resolving symptoms in minutes to hours. Current research is focused on identifying novel approaches to rapid-acting psychotherapeutics. Promising results from studies of novel classes of drugs and innovative brain stimulation therapies are currently being studied through both clinical and pre-clinical research, as described here. Research focused on understanding neurobiological mechanisms, effective therapeutic context, and implementation approaches are needed to maximize the potential reach of these therapies.
Identifiants
pubmed: 37349476
doi: 10.1038/s41386-023-01627-y
pii: 10.1038/s41386-023-01627-y
pmc: PMC10700482
doi:
Substances chimiques
Psychotropic Drugs
0
Ketamine
690G0D6V8H
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
10-14Informations de copyright
© 2023. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.
Références
J Psychopharmacol. 2014 Nov;28(11):983-92
pubmed: 25213996
Nat Med. 2021 Oct;27(10):1696-1700
pubmed: 34608328
Nat Med. 2022 Sep;28(9):1791-1796
pubmed: 36038628
N Engl J Med. 2022 Nov 3;387(18):1637-1648
pubmed: 36322843
Am J Psychiatry. 2022 Feb;179(2):152-162
pubmed: 35012326
J Neurol Sci. 2022 Sep 15;440:120332
pubmed: 35841696
Psychiatr Clin North Am. 2018 Sep;41(3):341-353
pubmed: 30098649
Expert Opin Investig Drugs. 2023 Jan;32(1):77-87
pubmed: 36696567
World Psychiatry. 2021 Oct;20(3):397-404
pubmed: 34505368
Br J Psychiatry. 1994 Jan;164(1):106-9
pubmed: 8137089
Drug Alcohol Depend Rep. 2021 Dec 10;2:100016
pubmed: 36845891
Transl Psychiatry. 2023 Feb 8;13(1):49
pubmed: 36755017
Neurotherapeutics. 2022 Jul;19(4):1229-1245
pubmed: 35817944
Biol Psychiatry. 2007 Dec 1;62(11):1208-16
pubmed: 17573044
Front Pharmacol. 2018 Jun 05;9:529
pubmed: 29922156
PLoS One. 2022 Feb 25;17(2):e0263252
pubmed: 35213554
Am J Drug Alcohol Abuse. 2018;44(1):56-63
pubmed: 28301217
J Clin Med. 2022 Jan 26;11(3):
pubmed: 35160085
Ont Health Technol Assess Ser. 2016 Mar 01;16(5):1-66
pubmed: 27099642
Nicotine Tob Res. 2020 Jan 27;22(1):89-95
pubmed: 30085292
Drug Alcohol Depend Rep. 2022 Jul 09;4:100076
pubmed: 36846579
Science. 2007 Jan 26;315(5811):531-4
pubmed: 17255515
Alcohol Clin Exp Res. 2022 Dec;46(12):2149-2159
pubmed: 36316764
Prog Neuropsychopharmacol Biol Psychiatry. 2020 Aug 30;102:109950
pubmed: 32339664
Nat Biotechnol. 2020 Apr;38(4):439-447
pubmed: 32042166
Front Psychiatry. 2018 Jul 24;9:277
pubmed: 30140240
Neuron. 2005 Mar 3;45(5):651-60
pubmed: 15748841
Addict Behav. 2023 Jun;141:107643
pubmed: 36791642
Biol Psychiatry. 2013 Jun 15;73(12):1204-12
pubmed: 23562618
J Psychopharmacol. 2012 Jul;26(7):994-1002
pubmed: 22406913
Adv Pharmacol. 2020;89:131-162
pubmed: 32616205
Am J Psychiatry. 2020 Feb 1;177(2):125-133
pubmed: 31786934
N Engl J Med. 2019 Sep 5;381(10):903-911
pubmed: 31483961
Nat Med. 2017 Jan;23(1):28-38
pubmed: 27918562
J Clin Med. 2022 Feb 11;11(4):
pubmed: 35207224
J Psychopharmacol. 2015 Mar;29(3):289-99
pubmed: 25586396
Alcohol Alcohol. 2021 Aug 30;56(5):565-572
pubmed: 33352584
Discov Ment Health. 2022;2(1):9
pubmed: 35509843
Nat Med. 2021 Jun;27(6):1025-1033
pubmed: 33972795
Neurosci Biobehav Rev. 2021 Jul;126:573-589
pubmed: 33989669
J Clin Psychiatry. 2022 May 30;83(4):
pubmed: 35649167
Alcohol Clin Exp Res. 2018 Oct;42(10):1961-1969
pubmed: 30025152
Am J Psychiatry. 2018 Feb 01;175(2):150-158
pubmed: 28969441
Psychiatry Res. 1987 Sep;22(1):11-9
pubmed: 3659217
Am J Psychiatry. 2020 Aug 1;177(8):716-726
pubmed: 32252538
Trends Pharmacol Sci. 2021 Nov;42(11):929-942
pubmed: 34565579
Drug Alcohol Depend. 2022 Oct 1;239:109606
pubmed: 36087563
J Neurol Sci. 2020 Nov 15;418:117149
pubmed: 33002757
Lancet. 2017 Jul 29;390(10093):480-489
pubmed: 28619476