Role of Brain Endothelin Receptor Type B (ET
Rats
Animals
Desoxycorticosterone Acetate
/ pharmacology
Tyrosine 3-Monooxygenase
/ metabolism
Olfactory Bulb
/ metabolism
Hypertension
/ chemically induced
Blood Pressure
Endothelins
/ metabolism
Receptor, Endothelin B
/ genetics
RNA, Messenger
/ metabolism
Endothelin-1
/ genetics
Receptor, Endothelin A
/ genetics
DOCA-salt
Hypertension
central nervous system
endothelin
endothelin receptor type B
olfactory bulb
tyrosine hydroxylase
Journal
Current vascular pharmacology
ISSN: 1875-6212
Titre abrégé: Curr Vasc Pharmacol
Pays: United Arab Emirates
ID NLM: 101157208
Informations de publication
Date de publication:
2023
2023
Historique:
received:
09
11
2022
revised:
05
05
2023
accepted:
22
05
2023
medline:
23
10
2023
pubmed:
23
6
2023
entrez:
23
6
2023
Statut:
ppublish
Résumé
We previously reported that endothelins (ETs) regulate tyrosine hydroxylase (TH) activity and expression in the olfactory bulb (OB) of normotensive and hypertensive animals. Applying an ET receptor type A (ET The aim of the present work was to evaluate the role of central ET DOCA-salt hypertensive rats were infused for 7 days with cerebrospinal fluid or IRL-1620 (ET Chronic administration of IRL-1620 decreased SBP in hypertensive rats but not in normotensive animals. Furthermore, the blockade of ET These findings suggest that brain ETs through the activation of ET
Sections du résumé
BACKGROUND
We previously reported that endothelins (ETs) regulate tyrosine hydroxylase (TH) activity and expression in the olfactory bulb (OB) of normotensive and hypertensive animals. Applying an ET receptor type A (ET
OBJECTIVE
The aim of the present work was to evaluate the role of central ET
METHODS
DOCA-salt hypertensive rats were infused for 7 days with cerebrospinal fluid or IRL-1620 (ET
RESULTS
Chronic administration of IRL-1620 decreased SBP in hypertensive rats but not in normotensive animals. Furthermore, the blockade of ET
CONCLUSION
These findings suggest that brain ETs through the activation of ET
Identifiants
pubmed: 37349999
pii: CVP-EPUB-132619
doi: 10.2174/1570161121666230622121956
doi:
Substances chimiques
Desoxycorticosterone Acetate
6E0A168OB8
Tyrosine 3-Monooxygenase
EC 1.14.16.2
Endothelins
0
Receptor, Endothelin B
0
RNA, Messenger
0
Endothelin-1
0
Receptor, Endothelin A
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
246-256Informations de copyright
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