Avoiding implant-related complications in medically compromised patients with or without unhealthy lifestyle/Elevated oxidative stress.


Journal

Periodontology 2000
ISSN: 1600-0757
Titre abrégé: Periodontol 2000
Pays: Denmark
ID NLM: 9313276

Informations de publication

Date de publication:
06 2023
Historique:
revised: 11 04 2023
received: 07 03 2023
accepted: 26 04 2023
medline: 16 8 2023
pubmed: 23 6 2023
entrez: 23 6 2023
Statut: ppublish

Résumé

Increased human life expectancy broadens the alternatives for missing teeth and played a role in the widespread use of dental implants and related augmentation procedures for the aging population. Though, many of these patients may have one or more diseases. These systemic conditions may directly lead to surgical complications, compromise implant/bone healing, or influence long-term peri-implant health and its response to biologic nuisances. Offering patients credible expectations regarding intra- and postoperative complications and therapeutic prognosis is an ethical and legal obligation. Clear identification of potential types of adverse effects, complications, or errors is important for decision-making processes as they may be related to different local, systemic, and technical aspects. Therefore, the present review structures the underlying biological mechanisms, clinical evidence, and clinical recommendations for the most common systemic risk factors for implant-related complications.

Identifiants

pubmed: 37350348
doi: 10.1111/prd.12503
doi:

Substances chimiques

Dental Implants 0

Types de publication

Journal Article Review

Langues

eng

Pagination

329-349

Informations de copyright

© 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Références

Vissink A, Spijkervet F, Raghoebar G. The medically compromised patient: are dental implants a feasible option? Oral Dis. 2018;24:253-260.
Chappuis V, Avila-Ortiz G, Araújo MG, Monje A. Medication-related dental implant failure: systematic review and meta-analysis. Clin Oral Impl Res. 2018;29:55-68.
Hwang D, Wang HL. Medical contraindications to implant therapy: part II: relative contraindications. Implant Dent. 2007;16:13-23.
Zucchelli G, Wang HL, Chambrone L. Complications and treatment errors in periodontal and implant therapy. Periodontol 2000. 2023;92(1):9-12. doi: 10.1111/prd.12442 [Epub ahead of print].
Tipton DA, Dabbous MK. Effects of nicotine on proliferation and extracellular matrix production of human gingival fibroblasts in vitro. J Periodontol. 1995;66:1056-1064.
Giannopoulou C, Geinoz A, Cimasoni G. Effects of nicotine on periodontal ligament fibroblasts in vitro. J Clin Periodontol. 1999;26:49-55.
Jensen K, Nizamutdinov D, Guerrier M, Afroze S, Dostal D, Glaser S. General mechanisms of nicotine-induced fibrogenesis. FASEB J. 2012;26:4778-4787.
Milanezi de Almeida J, Bosco AF, Bonfante S, Theodoro LH, Nagata MJH, Garcia VG. Nicotine-induced damage affects gingival fibroblasts in the gingival tissue of rats. J Periodontol. 2011;82:1206-1211.
Lahmouzi J, Simain-Sato F, Defresne MP, et al. Effect of nicotine on rat gingival fibroblasts in vitro. Connect Tissue Res. 2000;41:69-80.
Jenkins K, Javadi M, Borghaei RC. Interleukin-4 suppresses IL-17-induced expression of matrix metalloproteinase-3 in human gingival fibroblasts. J Periodontol. 2004;75:283-291.
Bulmanski Z, Brady M, Stoute D, Lallier TE. Cigarette smoke extract induces select matrix metalloproteinases and integrin expression in periodontal ligament fibroblasts. J Periodontol. 2012;83:787-796.
Javed F, Rahman I, Romanos GE. Tobacco-product usage as a risk factor for dental implants. Periodontol 2000. 2019;81:48-56.
Bain CA. Smoking and implant failure - benefits of a smoking cessation protocol. Int J Oral Maxillofac Implants. 1996;11:756-759.
Nitzan D, Mamlider A, Levin L, Schwartz-Arad D. Impact of smoking on marginal bone loss. Int J Oral Maxillofac Implants. 2005;20:605-609.
Sánchez-Pérez A, Moya-Villaescusa MJ, Caffesse RG. Tobacco as a risk factor for survival of dental implants. J Periodontol. 2007;78:351-359.
Manzano G, Montero J, Martín-Vallejo J, Del Fabbro M, Bravo M, Testori T. Risk factors in early implant failure: a meta-analysis. Implant Dent. 2016;25:272-280.
Moraschini V, Barboza E dS P. Success of dental implants in smokers and non-smokers: a systematic review and meta-analysis. Int J Oral Maxillofac Surg. 2016;45:205-215.
Nazeer J, Singh R, Suri P, et al. Evaluation of marginal bone loss around dental implants in cigarette smokers and nonsmokers. A comparative study. J Family Med Prim Care. 2020;9:729-734.
Haas R, Haimböck W, Mailath G, Watzek G. The relationship of smoking on peri-implant tissue: a retrospective study. J Prosthet Dent. 1996;76:592-596.
Lambert PM, Morris HF, Ochi S. The influence of smoking on 3-year clinical success of osseointegrated dental implants. Ann Periodontol. 2000;5:79-89.
Hinode D, Shin-ichi T, Yokoyama M, Fujisawa K, Yamauchi E, Miyamoto Y. Influence of smoking on osseointegrated implant failure: a meta-analysis. Clin Oral Implants Res. 2006;17:473-478.
Strietzel FP, Reichart PA, Kale A, Kulkarni M, Wegner B, Küchler I. Smoking interferes with the prognosis of dental implant treatment: a systematic review and meta-analysis. J Clin Periodontol. 2007;34:523-544.
Naseri R, Yaghini J, Feizi A. Levels of smoking and dental implants failure: a systematic review and meta-analysis. J Clin Periodontol. 2020;47:518-528.
Chambrone L, Preshaw PM, Ferreira JD, Rodrigues JA, Cassoni A, Shibli JA. Effects of tobacco smoking on the survival rate of dental implants placed in areas of maxillary sinus floor augmentation: a systematic review. Clin Oral Impl Res. 2014;25:408-416.
Kan JYK, Rungcharassaeng K, Lozada JL, Goodacre CJ. Effects of smoking on implant success in grafted maxillary sinuses. J Prosthet Dent. 1999;82:307-311.
Pimentel SP, Shiota R, Cirano FR, et al. Occurrence of peri-implant diseases and risk indicators at the patient and implant levels: a multilevel cross-sectional study. J Periodontol. 2018;89:1091-1100.
Roos-Jansaker AM, Renvert H, Lindahl C, Renvert S. Nine- to fourteen-year follow-up of implant treatment. Part III: factors associated with peri-implant lesions. J Clin Periodontol. 2006;33:296-301.
Costa FO, Lages EJP, Cortelli SC, et al. Association between cumulative smoking exposure, span since smoking cessation, and peri-implantitis: a cross-sectional study. Clin Oral Invest. 2022;26:4835-4846.
Sgolastra F, Petrucci A, Severino M, Gatto R, Monaco A. Smoking and the risk of peri-implantitis. A systematic review and meta-analysis. Clin Oral Impl Res. 2015;26:e62-e67.
Stacchi C, Berton F, Perinetti G, et al. Risk factors for peri-implantitis: effect of history of periodontal disease and smoking habits. A systematic review and meta-analysis. J Oral Maxillofac Res. 2016;7:e3.
Schwarz F, Derks J, Monje A, Wang HL. Peri-implantitis. J Clin Periodontol. 2018;45:S246-S266.
Rosa EF, Corraini P, Inoue G, et al. Effect of smoking cessation on non-surgical periodontal therapy: results after 24 months. J Clin Periodontol. 2014;41:1145-1153.
Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes. Diabetes Care. 2004;27:1047-1053.
Velander P, Theopold C, Hirsch T, et al. Impaired wound healing in an acute diabetic pig model and the effects of local hyperglycemia. Wound Repair Regen. 2008;16:288-293.
Castleberry SA, Almquist BD, Li W, et al. Self-assembled wound dressings silence MMP-9 and improve diabetic wound healing in vivo. Adv Mater. 2016;28:1809-1817.
Wan R, Weissman JP, Grundman K, Lang L, Grybowski DJ, Galiano RD. Diabetic wound healing: the impact of diabetes on myofibroblast activity and its potential therapeutic treatments. Wound Rep Reg. 2021;29:573-581.
Saito N, Mikami R, Mizutani K, et al. Impaired dental implant osseointegration in rat with streptozotocin-induced diabetes. J Periodontal Res. 2022;57:412-424.
Quintero DG, Winger JN, Khashaba R, Borke JL. Advanced glycation endproducts and rat dental implant osseointegration. J Oral Implantol. 2010;36:97-103.
Fiorellini JP, Chen PK, Nevins M, Nevins ML. A retrospective study of dental implants in diabetic patients. Int J Periodontics Restorative Dent. 2000;20:366-373.
Annibali S, Pranno N, Cristalli MP, La Monaca G, Polimeni A. Survival analysis of implant in patients with diabetes mellitus: a systematic review. Implant Dent. 2016;25:663-674.
Moraschini V, Barboza ESP, Peixoto GA. The impact of diabetes on dental implant failure: a systematic review and meta-analysis. Int J Oral Maxillofac Surg. 2016;45:1237-1245.
Chrcanovic BR, Albrektsson T, Wennerberg A. Diabetes and oral implant failure: a systematic review. J Dent Res. 2014;93:859-867.
Moy PK, Medina D, Shetty V, Aghaloo TL. Dental implant failure rates and associated risk factors. Int J Oral Maxillofac Implants. 2005;20:569-577.
Al Ansari Y, Shahwan H, Chrcanovic BR. Diabetes mellitus and dental implants: a systematic review and meta-analysis. Materials. 2022;15:3227.
Eskow CC, Oates TW. Dental implant survival and complication rate over 2 years for individuals with poorly controlled type 2 diabetes mellitus: diabetes and implant complications. Clin Implant Dent Relat Res. 2017;19:423-431.
Monje A, Catena A, Borgnakke WS. Association between diabetes mellitus/hyperglycaemia and peri-implant diseases: systematic review and meta-analysis. J Clin Periodontol. 2017;44:636-648.
Oates TW, Galloway P, Alexander P, et al. The effects of elevated hemoglobin A1c in patients with type 2 diabetes mellitus on dental implants. J Am Dent Assoc. 2014;145:1218-1226.
Dreyer H, Grischke J, Tiede C, et al. Epidemiology and risk factors of peri-implantitis: a systematic review. J Periodontal Res. 2018;53:657-681.
Alberti A, Morandi P, Zotti B, et al. Influence of diabetes on implant failure and peri-implant diseases: a retrospective study. Dent J. 2020;8:70.
Renvert S, Aghazadeh A, Hallström H, Persson GR. Factors related to peri-implantitis - a retrospective study. Clin Oral Impl Res. 2014;25:522-529.
Naujokat H, Kunzendorf B, Wiltfang J. Dental implants and diabetes mellitus-a systematic review. Int J Implant Dent. 2016;2:5.
Sykara M, Maniatakos P, Tentolouris A, Karoussis IK, Tentolouris N. The necessity of administrating antibiotic prophylaxis to patients with diabetes mellitus prior to oral surgical procedures - a systematic review. Diabetes Metab Syndr. 2022;16:102621.
Salari N, Ghasemi H, Mohammadi L, et al. The global prevalence of osteoporosis in the world: a comprehensive systematic review and meta-analysis. J Orthop Surg Res. 2021;16:609.
Otomo-Corgel J. Osteoporosis and osteopenia: implications for periodontal and implant therapy: osteoporosis and osteopenia: implications for periodontal and implant therapy. Periodontol 2000. 2012;59:111-139.
Goiato MC, dos Santos DM Jr, Santiago JF, Moreno A, Pellizzer EP. Longevity of dental implants in type IV bone: a systematic review. Int J Oral Maxillofac Surg. 2014;43:1108-1116.
Cakur B, Dağistan S, Sümbüllü MA. No correlation between mandibular and non-mandibular measurements in osteoporotic men. Acta Radiol. 2010;51:789-792.
Taguchi A. Triage screening for osteoporosis in dental clinics using panoramic radiographs. Oral Dis. 2010;16:316-327.
Pisulkar SG, Mistry RA, Nimonkar S, Dahihandekar C, Pisulkar G, Belkhode V. The correlation of mineral density of jaws with skeletal bone and its effect on implant stability in osteoporotic patients: a review of patient-based studies. Cureus. 2022;14:e27481.
Merheb J, Temmerman A, Rasmusson L, Kübler A, Thor A, Quirynen M. Influence of skeletal and local bone density on dental implant stability in patients with osteoporosis: implant stability and osteoporosis. Clin Implant Dent Relat Res. 2016;18:253-260.
Alsaadi G, Quirynen M, Komárek A, van Steenberghe D. Impact of local and systemic factors on the incidence of oral implant failures, up to abutment connection. J Clin Periodontol. 2007;34:610-617.
Alsaadi G, Quirynen M, Michiles K, Teughels W, Komárek A, van Steenberghe D. Impact of local and systemic factors on the incidence of failures up to abutment connection with modified surface oral implants. J Clin Periodontol. 2007;34:610-617.
de Medeiros FCFL, Kudo GAH, Leme BG, et al. Dental implants in patients with osteoporosis: a systematic review with meta-analysis. Int J Oral Maxillofac Surg. 2018;47:480-491.
Tabrizi R, Mousavi F, Ghasemi S, Ozkan BT. Does osteoporosis increase marginal bone loss around dental implants in the posterior of the maxilla? Int J Oral Maxillofac Surg. 2021;50:964-968.
Wagner F, Schuder K, Hof M, Heuberer S, Seemann R, Dvorak G. Does osteoporosis influence the marginal peri-implant bone level in female patients? A cross-sectional study in a matched collective: Wagner et al. Clin Implant Dent Relat Res. 2017;19:616-623.
Temmerman A, Rasmusson L, Kübler A, Thor A, Merheb J, Quirynen M. A prospective, controlled, multicenter study to evaluate the clinical outcome of implant treatment in women with osteoporosis/osteopenia: 5-year results. J Dent Res. 2019;98:84-90.
Dvorak G, Arnhart C, Heuberer S, Huber CD, Watzek G, Gruber R. Peri-implantitis and late implant failures in postmenopausal women: a cross-sectional study: peri-implantitis in postmenopausal women. J Clin Periodontol. 2011;38:950-955.
Chen H, Liu N, Xu X, Qu X, Lu E. Smoking, radiotherapy, diabetes and osteoporosis as risk factors for dental implant failure: a meta-analysis. PLoS One. 2013;8:e71955.
Lu B, Zhang X, Liu B. A systematic review and meta-analysis on influencing factors of failure of oral implant restoration treatment. Ann Palliat Med. 2021;10:12664-12677.
Gibreel S, Gassim Mohamed H, Raj Suraj A, Anil S. Osseointegration of dental implants and osteoporosis. In: Gabrić D, Vuletić M, eds. Current Concepts in Dental Implantology - From Science to Clinical Research. IntechOpen; 2022.
Tsolaki IN, Madianos PN, Vrotsos JA. Outcomes of dental implants in osteoporotic patients. A literature review. J Prosthodont. 2009;18:309-323.
Ruggiero SL, Dodson TB, Aghaloo T, Carlson ER, Ward BB, Kademani D. American Association of Oral and Maxillofacial Surgeons' position paper on medication-related osteonecrosis of the jaws-2022 update. J Oral Maxillofac Surg. 2022;80:920-943.
Diez-Perez A. Bisphosphonates. Bisphosphonates Maturitas. 2002;43:19-26.
Boquete-Castro A, Gómez-Moreno G, Calvo-Guirado JL, Aguilar-Salvatierra A, Delgado-Ruiz RA. Denosumab and osteonecrosis of the jaw. A systematic analysis of events reported in clinical trials. Clin Oral Impl Res. 2016;27:367-375.
Ottesen C, Schiodt M, Gotfredsen K. Efficacy of a high-dose antiresorptive drug holiday to reduce the risk of medication-related osteonecrosis of the jaw (MRONJ): a systematic review. Heliyon. 2020;6:e03795.
Memon S, Weltman RL, Katancik JA. Oral bisphosphonates: early endosseous dental implant success and crestal bone changes. A retrospective study. Int J Oral Maxillofac Implants. 2012;27:1216-1222.
Yajima N, Munakata M, Fuchigami K, Sanda M, Kasugai S. Influence of bisphosphonates on implant failure rates and characteristics of postmenopausal woman mandibular jawbone. J Oral Implantol. 2017;43:345-349.
Zahid TM, Wang BY, Cohen RE. Influence of bisphosphonates on alveolar bone loss around osseointegrated implants. J Oral Implantol. 2011;37:335-346.
Chrcanovic BR, Albrektsson T, Wennerberg A. Bisphosphonates and dental implants: a meta-analysis. Quintessence Int. 2016;47:329-342.
Sher J, Kirkham-Ali K, Luo JD, Miller C, Sharma D. Dental implant placement in patients with a history of medications related to osteonecrosis of the jaws: a systematic review. J Oral Implantol. 2021;47:249-268.
Holzinger D, Seemann R, Matoni N, Ewers R, Millesi W, Wutzl A. Effect of dental implants on bisphosphonate-related osteonecrosis of the jaws. J Oral Maxillofac Surg. 2014;72:1937.e1-1937.e8.
Walter C, Al-Nawas B, Wolff T, Schiegnitz E, Grötz KA. Dental implants in patients treated with antiresorptive medication - a systematic literature review. Int J Implant Dent. 2016;2:9.
Lazarovici TS, Yahalom R, Taicher S, Schwartz-Arad D, Peleg O, Yarom N. Bisphosphonate-related osteonecrosis of the jaw associated with dental implants. J Oral Maxillofac Surg. 2010;68:790-796.
Yao S, Ding X, Rong G, Zhou J, Zhang B. Association between malignant diseases and medication-related osteonecrosis of the jaw (MRONJ): a systematic review and meta-analysis. J Craniofac Surg. 2023;34:669-673.
Vescovi P, Nammour S. Bisphosphonate-related osteonecrosis of the jaw (BRONJ) therapy. A critical review. Minerva Stomatol. 2010;59:181-203, 204-13.
Pichardo SEC, van der Hee JG, Fiocco M, Appelman-Dijkstra NM, van Merkesteyn JPR. Dental implants as risk factors for patients with medication-related osteonecrosis of the jaws (MRONJ). Br J Oral Maxillofac Surg. 2020;58:771-776.
Ruggiero SL, Dodson TB, Aghaloo T, Carlson ER, Ward BB, Kademani D. AAOMS' position paper on MRONJ-2022 update. J Oral Maxillofac Surg. 2022;80:920-943.
Campisi G, Mauceri R, Bertoldo F, et al. Medication-related osteonecrosis of jaws (MRONJ) prevention and diagnosis: Italian consensus update 2020. Int J Environ Res Public Health. 2020;17:5998.
Lodi G, Sardella A, Salis A, Demarosi F, Tarozzi M, Carrassi A. Tooth extraction in patients taking intravenous bisphosphonates: a preventive protocol and case series. J Oral Maxillofac Surg. 2010;68:107-110.
Saia G, Blandamura S, Bettini G, et al. Occurrence of bisphosphonate-related osteonecrosis of the jaw after surgical tooth extraction. J Oral Maxillofac Surg. 2010;68:797-804.
Vescovi P, Giovannacci I, Merigo E, et al. Tooth extractions in high-risk patients under bisphosphonate therapy and previously affected with osteonecrosis of the jaws: surgical protocol supported by low-level laser therapy. J Craniofac Surg. 2015;26:696-699.
Ata-Ali J, Ata-Ali F, Peñarrocha-Oltra D, Galindo-Moreno P. What is the impact of bisphosphonate therapy upon dental implant survival? A systematic review and meta-analysis. Clin Oral Impl Res. 2016;27:e38-e46.
Pimolbutr K, Porter S, Fedele S. Osteonecrosis of the jaw associated with antiangiogenics in antiresorptive-naïve patient: a comprehensive review of the literature. Biomed Res Int. 2018;2018:1-14.
Curi MM, Condezo AFB, Ribeiro Kd CB, Cardoso CL. Long-term success of dental implants in patients with head and neck cancer after radiation therapy. Int J Oral Maxillofac Surg. 2018;47:783-788.
Gupta S. Dental implant survival rate in irradiated and non-radiated patients: a systematic review and meta-analysis. J Biol Regul Homeost Agents. 2021;35:53-65.
Batstone M. Reconstruction of major defects of the jaws. Aust Dent J. 2018;63:S108-S113.
Ihde S, Kopp S, Gundlach K, Konstantinović VS. Effects of radiation therapy on craniofacial and dental implants: a review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;107:56-65.
Georgiou KR, Hui SK, Xian CJ. Regulatory pathways associated with bone loss and bone marrow adiposity caused by aging, chemotherapy, glucocorticoid therapy and radiotherapy. Am J Stem Cells. 2012;1:205-224.
Costa S, Reagan MR. Therapeutic irradiation: consequences for bone and bone marrow adipose tissue. Front Endocrinol. 2019;10:587.
Schiegnitz E, Müller LK, Sagheb K, et al. Clinical long-term and patient-reported outcomes of dental implants in oral cancer patients. Int J Implant Dent. 2021;7:93.
Shih A, Miaskowski C, Dodd MJ, Stotts NA, MacPhail L. Mechanisms for radiation-induced oral mucositis and the consequences. Cancer Nurs. 2003;26:222-229.
Silverman S. Oral cancer: complications of therapy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999;88:122-126.
Shokouhi B, Cerajewska T. Radiotherapy and the survival of dental implants: a systematic review. Br J Oral Maxillofac Surg. 2022;60:422-429.
Doll C, Nack C, Raguse JD, et al. Survival analysis of dental implants and implant-retained prostheses in oral cancer patients up to 20 years. Clin Oral Invest. 2015;19:1347-1352.
Sammartino G, Marenzi G, Cioffi I, Teté S, Mortellaro C. Implant therapy in irradiated patients. J Craniofac Surg. 2011;22:443-445.
Javed F, Al-Hezaimi K, Al-Rasheed A, Almas K, Romanos GE. Implant survival rate after oral cancer therapy: a review. Oral Oncol. 2010;46:854-859.
Verdonck HWD, de Jong JMA, Granzier MEPG, Nieman FH, de Baat C, Stoelinga PJW. Intensity-modulated radiation therapy for oropharyngeal cancer: radiation dosage constraint at the anterior mandible. Oral Oncol. 2009;45:511-514.
Nooh N. Dental implant survival in irradiated oral cancer patients: a systematic review of the literature. Int J Oral Maxillofac Implants. 2013;28:1233-1242.
Shugaa-Addin B, Al-Shamiri H, Al-Maweri S, Tarakji B. The effect of radiotherapy on survival of dental implants in head and neck cancer patients. J Clin Exp Dent. 2016;8:e194-e200.
Asikainen P, Klemetti E, Kotilainen R, et al. Osseointegration of dental implants in bone irradiated with 40, 50 or 60 Gy doses. An experimental study with beagle dogs: titanium implants and irradiated bone. Clin Oral Implants Res. 1998;9:20-25.
Lee J, Lee JJB, Cha I, Park KR, Lee CG. Risk factor analysis of dental implants in patients with irradiated head and neck cancer. Head Neck. 2022;44:1816-1824.
Schoen PJ, Reintsema H, Raghoebar GM, Vissink A, Roodenburg JLN. The use of implant retained mandibular prostheses in the oral rehabilitation of head and neck cancer patients. A review and rationale for treatment planning. Oral Oncol. 2004;40:862-871.
Esposito M, Hirsch JM, Lekholm U, Thomsen P. Biological factors contributing to failures of osseointegrated oral implants, (II). Etiopathogenesis: biological factors contributing to failures of osseointegrated oral implants, (II). Etiopathogenesis. Eur J Oral Sci. 1998;106:721-764.
Visch LL, van Waas MAJ, Schmitz PIM, Levendag PC. A clinical evaluation of implants in irradiated oral cancer patients. J Dent Res. 2002;81:856-859.
Yerit KC, Posch M, Seemann M, et al. Implant survival in mandibles of irradiated oral cancer patients. Clin Oral Implants Res. 2006;17:337-344.
Claudy MP, Miguens SAQ, Celeste RK, Camara Parente R, Hernandez PAG, da Silva AN. Time interval after radiotherapy and dental implant failure: systematic review of observational studies and meta-analysis: radiotherapy and dental implant failure. Clin Implant Dent Relat Res. 2015;17:402-411.
Schliephake H, Neukam FW, Schmelzeisen R, Wichmann M. Long-term results of endosteal implants used for restoration of oral function after oncologic surgery. Int J Oral Maxillofac Surg. 1999;28:260-265.
Brogniez V, Lejuste P, Pecheur A, Reychler H. Dental prosthetic reconstruction of osseointegrated implants placed in irradiated bone. Int J Oral Maxillofac Implants. 1998;13:506-512.
Hancock PJ, Epstein JB, Sadler GR. Oral and dental management related to radiation therapy for head and neck cancer. J Can Dent Assoc. 2003;69:585-590.
Kovacs AF. The fate of osseointegrated implants in patients following oral cancer surgery and mandibular reconstruction. Head Neck. 2000;22:111-119.
Taylor TD, Worthington P. Osseointegrated implant rehabilitation of the previously irradiated mandible: results of a limited trial at 3 to 7 years. J Prosthet Dent. 1993;69:60-69.
Anderson L, Meraw S, Al-Hezaimi K, Wang HL. The influence of radiation therapy on dental Implantology. Implant Dent. 2013;22:31-38.
Mian TA, Van Putten MC, Kramer DC, Jacob RF, Boyer AL. Backscatter radiation at bone-titanium interface from high-energy x and gamma rays. Int J Radiat Oncol Biol Phys. 1987;13:1943-1947.
Harpaz R, Dahl RM, Dooling KL. Prevalence of immunosuppression among US adults, 2013. JAMA. 2016;316:2547-2548.
Duttenhoefer F, Fuessinger MA, Beckmann Y, Schmelzeisen R, Groetz KA, Boeker M. Dental implants in immunocompromised patients: a systematic review and meta-analysis. Int J Implant Dent. 2019;5:43.
Calder JDF, Buttery L, Revell PA, Pearse M, Polak JM. Apoptosis - a significant cause of bone cell death in osteonecrosis of the femoral head. J Bone Joint Surg Br. 2004;86:1209-1213.
Mitra R. Adverse effects of corticosteroids on bone metabolism: a review. PM R. 2011;3:466-471.
Shen EC, Fu E, Hsieh YD. Effects of cyclosporin a on dental alveolar bone: a histomorphometric study in rats. J Periodontol. 2001;72:659-665.
da Silva PF, Pallos D, Silva Queiroz C, Ricardo LH. Previous exposure to cyclosporine a and periodontal breakdown in rats. Arch Oral Biol. 2015;60:566-573.
Fujimoto T, Niimi A, Sawai T, Ueda M. Effects of steroid-induced osteoporosis on osseointegration of titanium implants. Int J Oral Maxillofac Implants. 1998;13:183-189.
Petsinis V, Kamperos G, Alexandridi F, Alexandridis K. The impact of glucocorticosteroids administered for systemic diseases on the osseointegration and survival of dental implants placed without bone grafting-a retrospective study in 31 patients. J Craniomaxillofac Surg. 2017;45:1197-1200.
Thomason JM, Girdler NM, Kendall-Taylor P, Wastell H, Weddel A, Seymour RA. An investigation into the need for supplementary steroids in organ transplant patients undergoing gingival surgery: a double-blind, split-mouth, cross-over study. J Clin Periodontol. 1999;26:577-582.
Gibson N, Ferguson JW. Steroid cover for dental patients on long-term steroid medication: proposed clinical guidelines based upon a critical review of the literature. Br Dent J. 2004;197:681-685.
Burtscher D, Dalla TD. Dental implant procedures in immunosuppressed organ transplant patients: a systematic review. Int J Oral Maxillofac Surg. 2022;51:380-387.
Weiss RA. How does HIV cause AIDS? Science. 1993;260(5112):1273-1279.
Ata-Ali J, Ata-Ali F, Di-Benedetto N, Bagán L, Bagán JV. Does HIV infection have an impact upon dental implant osseointegration? A systematic review. Med Oral Patol Oral Cir Bucal. 2015;20:e347-e356.
Castronuovo D, Cacopardo B, Pinzone MR, et al. Bone disease in the setting of HIV infection: update and review of the literature. Eur Rev Med Pharmacol Sci. 2013;17:2413-2419.
Dolan SE, Huang JS, Killilea KM, Sullivan MP, Aliabadi N, Grinspoon S. Reduced bone density in HIV-infected women. AIDS. 2004;18:475-483.
Yin MT, Modarresi R, Shane E, et al. Effects of HIV infection and antiretroviral therapy with ritonavir on induction of osteoclast-like cells in postmenopausal women. Osteoporos Int. 2011;22:1459-1468.
Fakruddin JM, Laurence J. HIV envelope gp120-mediated regulation of Osteoclastogenesis via receptor activator of nuclear factor κB ligand (RANKL) secretion and its modulation by certain HIV protease inhibitors through interferon-γ/RANKL cross-talk. J Biol Chem. 2003;278:48251-48258.
Fakruddin JM, Laurence J. Interactions among human immunodeficiency virus (HIV)-1, interferon- γ and receptor of activated NF-κ B ligand (RANKL): implications for HIV pathogenesis. Clin Exp Immunol. 2004;137:538-545.
May MC, Andrews PN, Daher S, Reebye UN. Prospective cohort study of dental implant success rate in patients with AIDS. Int J Implant Dent. 2016;2:20.
Glick M, Abel SN, Muzyka BC, Delorenzo M. Dental complications after treating patients with Aids. J Am Dent Assoc. 1994;125:296-301.
Patton LL, Shugars DA, Bonito AJ. A systematic review of complication risks for HIV-positive patients undergoing invasive dental procedures. J Am Dent Assoc. 2002;133:195-203.
Neumeier TT, Reddy M, Geurs N, Hill J, Neumeier H. Longitudinal study of dental implants in HIV−positive patients. J Prosthodont. 2022;31:115-120.
Vidal F, Peres RV, Souza RC, Gonçalves C, Pavan P, Gonçalves LS. Dental implants in individuals living with HIV-1: results from a prospective study in patients undergoing highly active antiretroviral therapy. Spec Care in Dentist. 2022;42:112-119.
Sivakumar I, Arunachalam S, Choudhary S, Buzayan MM. Does HIV infection affect the survival of dental implants? A systematic review and meta-analysis. J Prosthet Dent. 2021;125:862-869.
Lemos CAA, Verri FR, Cruz RS, Santiago Júnior JF, Faverani LP, Pellizzer EP. Survival of dental implants placed in HIV-positive patients: a systematic review. Int J Oral Maxillofac Surg. 2018;47:1336-1342.
Casula L, Poli A, Clemente T, Artuso G, Capparé P, Gherlone EF. Prevalence of peri-implantitis in a sample of HIV-positive patients. Clin Exp Dent Res. 2021;7:1002-1013.
Gay-Escoda C, Perez-Alvarez D, Camps-Font O, Figueiredo R. Long-term outcomes of oral rehabilitation with dental implants in HIV-positive patients: a retrospective case series. Med Oral. 2016;21:e385-e391.
Sabbah A, Hicks J, MacNeill B, et al. A retrospective analysis of dental implant survival in HIV patients. J Clin Periodontol. 2019;46:363-372.
de Oliveira MA, Pallos D, Mecca F, et al. Dental implants in patients seropositive for HIV. J Am Dent Assoc. 2020;151:863-869.
Pikner SS, Gröndahl K. Radiographic analyses of “advanced” marginal bone loss around Brånemark® dental implants. Clin Implant Dent Relat Res. 2009;11:120-133.
Mahy M, Marsh K, Sabin K, Wanyeki I, Daher J, Ghys PD. HIV estimates through 2018: data for decision-making. AIDS. 2019;33:S203-S211.
Shirlaw P, Chikte U, MacPhail L, Schmidt-Westhausen A, Croser D, Reichart P. Oral and dental care and treatment protocols for the management of HIV-infected patients: oral care and treatment protocols in HIV. Oral Dis. 2002;8:136-143.
Zam SNA, Sylvyana M, Sjamsudin E. Management of third molar surgery in HIV-positive patients. Oral Dis. 2020;26:145-148.
Nabel EG. Cardiovascular disease. N Engl J Med. 2003;349:60-72.
Khadivi V, Anderson J, Zarb GA. Cardiovascular disease and treatment outcomes with osseointegration surgery. J Prosthet Dent. 1999;81:533-536.
Neves J, de Araújo NM, Oliveira P, Martins dos Santos J, Malo P. Risk factors for implant failure and peri-implant pathology in systemic compromised patients: outcome predictors in the systemically compromised. J Prosthodont. 2018;27:409-415.
Niedermaier R, Stelzle F, Riemann M, Bolz W, Schuh P, Wachtel H. Implant-supported immediately loaded fixed full-arch dentures: evaluation of implant survival rates in a case cohort of up to 7 years: immediately loaded fixed full-arch dentures. Clin Implant Dent Relat Res. 2017;19:4-19.
Nobre M d A, Maló P, Gonçalves Y, Sabas A, Salvado F. Outcome of dental implants in diabetic patients with and without cardiovascular disease: a 5-year post-loading retrospective study. Eur J Oral Implantol. 2016;9:87-95.
Wu X, Al-Abedalla K, Eimar H, et al. Antihypertensive medications and the survival rate of osseointegrated dental implants: a cohort study: antihypertensive drugs and dental implants. Clin Implant Dent Relat Res. 2016;18:1171-1182.
Hasanoglu Erbasar GN, Hocaoğlu TP, Erbasar RC. Risk factors associated with short dental implant success: a long-term retrospective evaluation of patients followed up for up to 9 years. Braz Oral Res. 2019;33:e030.
Mayta-Tovalino F, Mendoza-Martiarena Y, Romero-Tapia P, et al. An 11-year retrospective research study of the predictive factors of peri-implantitis and implant failure: analytic-multicentric study of 1279 implants in Peru. Int J Dent. 2019;2019:1-8.
Nguyen TTH, Eo MY, Cho YJ, Myoung H, Kim SM. 7-mm-long dental implants: retrospective clinical outcomes in medically compromised patients. J Korean Assoc Oral Maxillofac Surg. 2019;45:260.
Schimmel M, Srinivasan M, McKenna G, Müller F. Effect of advanced age and/or systemic medical conditions on dental implant survival: a systematic review and meta-analysis. Clin Oral Impl Res. 2018;29:311-330.
Froum S, Hengjeerajaras P, Liu KY, Maketone P, Patel V, Shi Y. The link between periodontitis/peri-implantitis and cardiovascular disease: a systematic literature review. Int J Periodontics Restorative Dent. 2020;40:e229-e233.
Hwang D, Wang HL. Medical contraindications to implant therapy: part I: absolute contraindications. Implant Dent. 2006;15:353-360.
Diz P, Scully C, Sanz M. Dental implants in the medically compromised patient. J Dent. 2013;41:195-206.
Jolly DE. Evaluation of the medical history. Anesth Prog. 1995;42:84-89.
Kämmerer PW, Frerich B, Liese J, Schiegnitz E, Al-Nawas B. Oral surgery during therapy with anticoagulants-a systematic review. Clin Oral Invest. 2015;19:171-180.
Dawoud BES, Kent S, Tabbenor O, George P, Dhanda J. Dental implants and risk of bleeding in patients on oral anticoagulants: a systematic review and meta-analysis. Int J Implant Dent. 2021;7:82.
Miziara LNB, Sendyk WR, Ortega KL, Gallottini M, Sendyk DI, Martins F. Risk of bleeding during implant surgery in patients taking antithrombotics: a systematic review. Semin Thromb Hemost. 2021;47:702-708.
Malik A, Majeed S. Effect of antiplatelet therapy on minor dental procedures. Natl J Maxillofac Surg. 2020;11:64-66.
Iwabuchi H, Imai Y, Asanami S, et al. Evaluation of postextraction bleeding incidence to compare patients receiving and not receiving warfarin therapy: a cross-sectional, multicentre, observational study. BMJ Open. 2014;4:e005777.
Airoldi G, Campanini M. Apixaban. Apixaban it J Med. 2011;5:128-134.
Napeñas JJ, Patton LL. Bleeding and clotting disorders. In: Glick M, Greenberg MS, Lockhart PB, Challacombe SJ, eds. Burket's Oral Medicine. 1st ed. Wiley; 2021:665-704.
Douketis J, Tosetto A, Marcucci M, et al. Risk of recurrence after venous thromboembolism in men and women: patient level meta-analysis. BMJ. 2011;342:d813.
Yong JW, Yang LX, Ohene BE, Zhou YJ, Wang ZJ. Periprocedural heparin bridging in patients receiving oral anticoagulation: a systematic review and meta-analysis. BMC Cardiovasc Disord. 2017;17:295.
Römer P, Heimes D, Pabst A, Becker P, Thiem DGE, Kämmerer PW. Bleeding disorders in implant dentistry: a narrative review and a treatment guide. Int J Implant Dent. 2022;8:20.
Morse RM. The definition of alcoholism. JAMA. 1992;268:1012.
Ouanounou A, Hassanpour S, Glogauer M. The influence of systemic medications on osseointegration of dental implants. J Can Dent Assoc. 2016;82:g7.
Istituto Nazionale per gli Alimenti e la Nutrizione. Linee guida per una sana alimentazione italiana. Ministero delle Politiche Agricole e Forestali, INRAN; 2003.
Baran DT, Teitelbaum SL, Bergfeld MA, Parker G, Cruvant EM, Avioli LV. Effect of alcohol ingestion on bone and mineral metabolism in rats. Am J Physiol. 1980;238:E507-E510.
Turner RT, Aloia RC, Segel LD, Hannon KS, Bell NH. Chronic alcohol treatment results in disturbed vitamin D metabolism and skeletal abnormalities in rats. Alcohol Clin Exp Res. 1988;12:159-162.
Friday KE, Howard GA. Ethanol inhibits human bone cell proliferation and function in vitro. Metabolism. 1991;40:562-565.
Farley JR, Fitzsimmons R, Taylor AK, Jorch UM, Lau KHW. Direct effects of ethanol on bone resorption and formation in vitro. Arch Biochem Biophys. 1985;238:305-314.
Koo S, König B, Mizusaki CI, Allegrini S, Yoshimoto M, Carbonari MJ. Effects of alcohol consumption on osseointegration of titanium implants in rabbits. Implant Dent. 2004;13:232-237.
Diamond T, Stiel D, Lunzer M, Wilkinson M, Posen S. Ethanol reduces bone formation and may cause osteoporosis. Am J Med. 1989;86:282-288.
Taïeb J, Delarche C, Ethuin F, et al. Ethanol-induced inhibition of cytokine release and protein degranulation in human neutrophils. J Leukoc Biol. 2002;72:1142-1147.
Lockhart PB, Gibson J, Pond SH, Leitch J. Dental management considerations for the patient with an acquired coagulopathy. Part 1: coagulopathies from systemic disease. Br Dent J. 2003;195:439-445.
Block MS, Christensen BJ, Mercante DE, Chapple AG. What factors are associated with implant failure? J Oral Maxillofac Surg. 2021;79:91-97.
Alissa R, Oliver RJ. Influence of prognostic risk indicators on osseointegrated dental implant failure: a matched case-control analysis. J Oral Implantol. 2012;38:51-61.
Carnelio S, Khan SA, Rodrigues G. Definite, probable or dubious: antioxidants trilogy in clinical dentistry. Br Dent J. 2008;204:29-32.
Kopáni M, Celec P, Danišovič L, Michalka P, Biró C. Oxidative stress and electron spin resonance. Clin Chim Acta. 2006;364:61-66.
Pua ML, Yoshitomi T, Chonpathompikunlert P, Hirayama A, Nagasaki Y. Redox-active injectable gel using thermo-responsive nanoscale polyion complex flower micelle for noninvasive treatment of local inflammation. J Control Release. 2013;172:914-920.
Yanez M, Blanchette J, Jabbarzadeh E. Modulation of inflammatory response to implanted biomaterials using natural compounds. Curr Pharm des. 2018;23:6347-6357.
Lobo V, Patil A, Phatak A, Chandra N. Free radicals, antioxidants and functional foods: impact on human health. Pharmacogn Rev. 2010;4:118-126.
Aksakalli S. Antioxidants in dentistry: review of literature. Dentistry. 2013;4:1.
Knaś M, Maciejczk M, Waszkiel D, Zalewska A. Oxidative stress and salivary antioxidants. Dent Med Probl. 2013;50:461-466.
Esterbauer H, Puhl H, Dieber-rotheneder M, Waeg G, Rabl H. Effect of antioxidants on oxidative modification of LDL. Ann Med. 1991;23:573-581.
Tóthová L, Celec P. Oxidative stress and antioxidants in the diagnosis and therapy of periodontitis. Front Physiol. 2017;8:1055.
TAAo P. Parameter on chronic periodontitis with slight to moderate loss of periodontal support. J Periodontol. 2000;71:853-855.
Kornman KS. Mapping the pathogenesis of periodontitis: a new look. J Periodontol. 2008;79:1560-1568.
Muniz FWMG, Nogueira SB, Mendes FLV, et al. The impact of antioxidant agents complimentary to periodontal therapy on oxidative stress and periodontal outcomes: a systematic review. Arch Oral Biol. 2015;60:1203-1214.
Tsaryk R, Kalbacova M, Hempel U, et al. Response of human endothelial cells to oxidative stress on Ti6Al4V alloy. Biomaterials. 2007;28:806-813.
Lee MC, Yoshino F, Shoji H, et al. Characterization by electron spin resonance spectroscopy of reactive oxygen species generated by titanium dioxide and hydrogen peroxide. J Dent Res. 2005;84:178-182.
Bressan E, Ferroni L, Gardin C, et al. Metal nanoparticles released from dental implant surfaces: potential contribution to chronic inflammation and peri-implant bone loss. Materials. 2019;12:2036.
Delgado-Ruiz R, Romanos G. Potential causes of titanium particle and ion release in implant dentistry: a systematic review. Int J Mol Sci. 2018;19:3585.
Abdulhameed EA, Al-Rawi NH, Omar M, Khalifa N, Samsudin ABR. Titanium dioxide dental implants surfaces related oxidative stress in bone remodeling: a systematic review. PeerJ. 2022;10:e12951.
Caton JG, Armitage G, Berglundh T, et al. A new classification scheme for periodontal and peri-implant diseases and conditions - introduction and key changes from the 1999 classification. J Periodontol. 2018;89:S1-S8.
Esquivel-Chirino C, Gómez-Landeros JC, Carabantes-Campos EP, et al. The impact of oxidative stress on dental implants. EJDENT. 2021;2:1-8.
Mousavi Jazi M, Sadeghi Pour Rodsari HR, Mirmiran F. Level of oxidative stress markers in Peri-implant crevicular fluid and their correlation with clinical parameters. J Dent. 2015;12:340-346.
Mouthuy PA, Snelling SJB, Dakin SG, et al. Biocompatibility of implantable materials: an oxidative stress viewpoint. Biomaterials. 2016;109:55-68.
Kaur G, Kathariya R, Bansal S, Singh A, Shahakar D. Dietary antioxidants and their indispensable role in periodontal health. J Food Drug Anal. 2016;24:239-246.
Tardy BL, Richardson JJ, Nithipipat V, et al. Protein adsorption and coordination-based end-tethering of functional polymers on metal-phenolic network films. Biomacromolecules. 2019;20:1421-1428.
Harmankaya N, Igawa K, Stenlund P, Palmquist A, Tengvall P. Healing of complement activating Ti implants compared with non-activating Ti in rat tibia. Acta Biomater. 2012;8:3532-3540.
Kalltorp M, Askendal A, Thomsen P, Tengvall P. Inflammatory cell recruitment, distribution, and chemiluminescence response at IgG precoated- and thiol functionalized gold surfaces. J Biomed Mater Res. 1999;47:251-259.
Di H, Qiaoxia L, Yujie Z, et al. Ag nanoparticles incorporated tannic acid/nanoapatite composite coating on Ti implant surfaces for enhancement of antibacterial and antioxidant properties. Surf Coat Technol. 2020;399:126169.
Catauro M, Papale F, Bollino F, et al. Silica/quercetin sol-gel hybrids as antioxidant dental implant materials. Sci Technol Adv Mater. 2015;16:035001.
Catauro M, Bollino F, Papale F, Ferrara C, Mustarelli P. Silica-polyethylene glycol hybrids synthesized by sol-gel: biocompatibility improvement of titanium implants by coating. Mater Sci Eng C Mater Biol Appl. 2015;55:118-125.
Rathee P, Chaudhary H, Rathee S, Rathee D, Kumar V, Kohli K. Mechanism of action of flavonoids as anti-inflammatory agents: a review. Inflamm Allergy Drug Targets. 2009;8:229-235.
Catauro M, Bollino F, Papale F, Piccolella S, Pacifico S. Sol-gel synthesis and characterization of SiO2/PCL hybrid materials containing quercetin as new materials for antioxidant implants. Mater Sci Eng C Mater Biol Appl. 2016;58:945-952.
Re R, Pellegrini N, Proteggente A, Pannala A, Yang M, Rice-Evans C. Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radic Biol Med. 1999;26:1231-1237.
Graham HD. Stabilization of the Prussian blue color in the determination of polyphenols. J Agric Food Chem. 1992;40:801-805.
Boraldi F, Annovi G, Paolinelli-Devincenzi C, Tiozzo R, Quaglino D. The effect of serum withdrawal on the protein profile of quiescent human dermal fibroblasts in primary cell culture. Proteomics. 2008;8:66-82.
Chow CK, Ibrahim W, Wei Z, Chan AC. Vitamin E regulates mitochondrial hydrogen peroxide generation. Free Radic Biol Med. 1999;27:580-587.
Costa L, Carpentieri I, Bracco P. Post electron-beam irradiation oxidation of orthopaedic ultra-high molecular weight polyethylene (UHMWPE) stabilized with vitamin E. Polym Degrad Stab. 2009;94:1542-1547.
Ozawa R, Saita M, Sakaue S, et al. Redox injectable gel protects osteoblastic function against oxidative stress and suppresses alveolar bone loss in a rat peri-implantitis model. Acta Biomater. 2020;110:82-94.
Qi F, Huang H, Wang M, Rong W, Wang J. Applications of antioxidants in dental procedures. Antioxidants. 2022;11:2492.
Stevens JL, Feelisch M, Martin DS. Perioperative oxidative stress: the unseen enemy. Anesth Analg. 2019;129:1749-1760.
Chang D, Wang F, Zhao YS, Pan HZ. Evaluation of oxidative stress in colorectal cancer patients. Biomed Environ Sci. 2008;21:286-289.
Leufkens AM, van Duijnhoven FJB, Woudt SHS, et al. Biomarkers of oxidative stress and risk of developing colorectal cancer: a cohort-nested case-control study in the European Prospective Investigation into Cancer and Nutrition. Am J Epidemiol. 2012;175:653-663.
Zińczuk M, Zaręba R, Markowski K, et al. Antioxidant barrier, redox status, and oxidative damage to biomolecules in patients with colorectal cancer. Can malondialdehyde and catalase be markers of colorectal cancer advancement? Biomolecules. 2019;9:637.
Chiang FF, Chao TH, Huang SC, Cheng CH, Tseng YY, Huang YC. Cysteine regulates oxidative stress and glutathione-related Antioxidative capacity before and after colorectal tumor resection. Int J Mol Sci. 2022;23:9581.

Auteurs

Gregorio Guabello (G)

Endocrinology Unit, IRCCS Galeazzi Sant'Ambrogio Hospital, Milan, Italy.

Francesco Zuffetti (F)

Section of Implant Dentistry and Oral Rehabilitation, IRCCS Galeazzi Sant'Ambrogio Hospital, Dental Clinic, Milan, Italy.

Andrea Ravidà (A)

Department of Periodontics and Preventive Dentistry, University of Pittsburgh School of Dental Medicine, Pittsburgh, Pennsylvania, USA.

Matteo Deflorian (M)

Section of Implant Dentistry and Oral Rehabilitation, IRCCS Galeazzi Sant'Ambrogio Hospital, Dental Clinic, Milan, Italy.

Giorgio Carta (G)

Argo Academy International Research Bologna, Bologna, Italy.
Private Practice, Bologna, Italy.
Lake Como Institute, Como, Italy.

Muhammad H A Saleh (MHA)

Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michigan, USA.

Matteo Serroni (M)

Department of Innovative Technologies in Medicine & Dentistry, University 'G. D'Annunzio', Chieti-Pescara, Italy.

Bernhard Pommer (B)

Academy for Oral Implantology, Vienna, Austria.
Department of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano, Milan, Italy.

Georg Watzek (G)

Academy for Oral Implantology, Vienna, Austria.

Luca Francetti (L)

IRCCS Galeazzi Sant'Ambrogio Hospital, Dental Clinic, Milan, Italy.
Department of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano, Milan, Italy.

Tiziano Testori (T)

Section of Implant Dentistry and Oral Rehabilitation, IRCCS Galeazzi Sant'Ambrogio Hospital, Dental Clinic, Milan, Italy.
Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michigan, USA.
Department of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano, Milan, Italy.
Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts, USA.

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