Extensive complex neocortical movement topography devolves to simple output following experimental stroke in mice.
complex movement
intracortical microstimulation
middle cerebral artery stroke
motor cortex
motor output
neocortex
Journal
Frontiers in systems neuroscience
ISSN: 1662-5137
Titre abrégé: Front Syst Neurosci
Pays: Switzerland
ID NLM: 101477946
Informations de publication
Date de publication:
2023
2023
Historique:
received:
09
02
2023
accepted:
19
05
2023
medline:
23
6
2023
pubmed:
23
6
2023
entrez:
23
6
2023
Statut:
epublish
Résumé
The neocortex encodes complex and simple motor outputs in all mammalian species that have been tested. Given that changes in neocortical reorganization (and corresponding corticospinal output) have been implicated in long term motor recovery after stroke injury, there remains a need to understand this biology in order to expedite and optimize clinical care. Here, changes in the neocortical topography of complex and simple movement outputs were evaluated in mice following experimental middle cerebral artery occlusion (MCAo). Neocortical motor output was defined using long-duration parameters of intracortical microstimulation (LD-ICMS) based on area and spatial coordinates of separate motor output types to build upon our recent report in uninjured mice. LD-ICMS test sites that elicited complex (multi-joint) movement, simple (single skeletal joint) movement, as well as co-elicited FORELIMB + HINDLIMB responses were detected and recorded. Forelimb reaching behavior was assessed using the single pellet reaching (SPR) task. At 6 weeks post-surgery, behavioral deficits persisted and neocortical territories for separate movements exhibited differences in neocortical area, and spatial location, and differed between MCAo-Injured animals (i.e., the MCAo group) and Sham-Injured animals (i.e., the Control group). MCAo-Injury reduced neocortical area of complex movements while increasing area of simple movements. Limited effects of injury were detected for spatial coordinates of neocortical movements. Significant positive correlations were detected between final SPR performance and either area of complex retract or area of co-occurring FORELIMB + HINDLIMB sites.
Identifiants
pubmed: 37350800
doi: 10.3389/fnsys.2023.1162664
pmc: PMC10282139
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1162664Subventions
Organisme : NIGMS NIH HHS
ID : K12 GM111726
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS114651
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002645
Pays : United States
Informations de copyright
Copyright © 2023 Wolsh, Brown, Brown, Pratt and Boychuk.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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