HMG-CoA Reductase Inhibitors for Traumatic Brain Injury.
Cholesterol
Concussion
Inflammation
Statins
Trauma
Traumatic brain injury
Journal
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
ISSN: 1878-7479
Titre abrégé: Neurotherapeutics
Pays: United States
ID NLM: 101290381
Informations de publication
Date de publication:
Oct 2023
Oct 2023
Historique:
accepted:
09
06
2023
pmc-release:
01
10
2024
medline:
30
11
2023
pubmed:
23
6
2023
entrez:
23
6
2023
Statut:
ppublish
Résumé
Traumatic brain injuries (TBIs) are associated with high morbidity and mortality due to both the original insult as well as the destructive biological response that follows. Medical management aims to slow or even halt secondary neurological injury while simultaneously laying the groundwork for recovery. Statins are one class of medications that is showing increased promise in the management of TBI. Used extensively in cardiovascular disease, these drugs were originally developed as competitive inhibitors within the cholesterol production pipeline. They are now used in diverse disease states due to their pleiotropic effects on other biological processes such as inflammation and angiogenesis. Preclinical studies, retrospective reviews, and randomized clinical trials have shown a variety of benefits in the management of TBI, but to date, no large-scale randomized clinical trial has been performed. Despite this limitation, statins' early promise and well-tolerated side effect profile make them a promising new tool in the management of TBIs. More bench and clinical studies are needed to delineate proper treatment regimens as well as understand their true potential.
Identifiants
pubmed: 37351829
doi: 10.1007/s13311-023-01399-9
pii: 10.1007/s13311-023-01399-9
pmc: PMC10684840
doi:
Substances chimiques
Hydroxymethylglutaryl-CoA Reductase Inhibitors
0
Cholesterol
97C5T2UQ7J
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1538-1545Informations de copyright
© 2023. The American Society for Experimental Neurotherapeutics, Inc.
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