Recent treatment advances and practical management of hepatitis D virus.
Hepatitis D virus
bulevirtide
lonafarnib
nucleic acid polymer REP 2139
pegylated interferon
Journal
Clinical medicine (London, England)
ISSN: 1473-4893
Titre abrégé: Clin Med (Lond)
Pays: England
ID NLM: 101092853
Informations de publication
Date de publication:
07 2023
07 2023
Historique:
medline:
2
8
2023
pubmed:
24
6
2023
entrez:
23
6
2023
Statut:
ppublish
Résumé
Hepatitis D virus (HDV), also referred to as hepatitis delta virus, is the smallest virus capable of causing human disease. It is unable to replicate on its own and can only propagate in the presence of hepatitis B virus (HBV). Infection with both HBV and HDV frequently results in more severe disease than HBV alone, with higher instances of cirrhosis, liver failure and hepatocellular carcinoma (HCC). Thus, there is a need for effective treatment for HDV; however, currently approved treatment options are very limited both in terms of their efficacy and availability. This makes the management of HDV a challenge for physicians. In this review, we look at the background, diagnosis and treatment of HDV, informed by our hospital data, to set out the optimal management of HDV; we also explore novel treatment options for this disease.
Identifiants
pubmed: 37353306
pii: clinmed.2022-0556
doi: 10.7861/clinmed.2022-0556
pmc: PMC10541033
doi:
Substances chimiques
Antiviral Agents
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
403-408Informations de copyright
© Royal College of Physicians 2023. All rights reserved.
Références
Drugs. 2020 Oct;80(15):1601-1605
pubmed: 32926353
Viruses. 2022 Jan 28;14(2):
pubmed: 35215860
J Res Med Sci. 2012 Oct;17(10):967-74
pubmed: 23825999
Microorganisms. 2021 Dec 17;9(12):
pubmed: 34946209
Gut. 2015 Mar;64(3):469-82
pubmed: 24721903
Hepatology. 2018 Apr;67(4):1224-1236
pubmed: 29152762
J Hepatol. 2020 Sep;73(3):523-532
pubmed: 32335166
Liver Int. 2018 Apr;38(4):611-618
pubmed: 28834623
Hepatol Commun. 2020 Nov 13;5(2):189-202
pubmed: 33553968
Semin Liver Dis. 2012 Aug;32(3):220-7
pubmed: 22932970
Gut. 2021 Sep;70(9):1782-1794
pubmed: 34103404
Lancet Infect Dis. 2023 Jan;23(1):117-129
pubmed: 36113537
J Hepatol. 2022 Feb;76(2):464-469
pubmed: 34699951
ACS Infect Dis. 2019 May 10;5(5):675-687
pubmed: 30199230
Lancet Gastroenterol Hepatol. 2017 Dec;2(12):877-889
pubmed: 28964701
J Hepatol. 2022 Dec;77(6):1525-1531
pubmed: 35973578
Gut. 2019 Mar;68(3):512-521
pubmed: 30228220
J Hepatol. 2016 Sep;65(3):490-8
pubmed: 27132170
Hepatology. 2022 Jun;75(6):1551-1565
pubmed: 34860418
J Hepatol. 2022 Nov;77(5):1422-1430
pubmed: 35752223
Semin Liver Dis. 2012 Aug;32(3):228-36
pubmed: 22932971
Gastroenterol Rep (Oxf). 2019 Jun 23;7(4):231-245
pubmed: 32477569
Hepatology. 2018 Apr;67(4):1560-1599
pubmed: 29405329
World J Hepatol. 2013 Dec 27;5(12):666-75
pubmed: 24409335
Pathogens. 2022 Apr 27;11(5):
pubmed: 35631038
J Exp Pharmacol. 2021 Apr 16;13:461-468
pubmed: 33889032
J Hepatol. 2017 Aug;67(2):370-398
pubmed: 28427875