Histone demethylases in the regulation of immunity and inflammation.
Journal
Cell death discovery
ISSN: 2058-7716
Titre abrégé: Cell Death Discov
Pays: United States
ID NLM: 101665035
Informations de publication
Date de publication:
23 Jun 2023
23 Jun 2023
Historique:
received:
13
03
2023
accepted:
15
06
2023
revised:
22
05
2023
medline:
24
6
2023
pubmed:
24
6
2023
entrez:
23
6
2023
Statut:
epublish
Résumé
Pathogens or danger signals trigger the immune response. Moderate immune response activation removes pathogens and avoids excessive inflammation and tissue damage. Histone demethylases (KDMs) regulate gene expression and play essential roles in numerous physiological processes by removing methyl groups from lysine residues on target proteins. Abnormal expression of KDMs is closely associated with the pathogenesis of various inflammatory diseases such as liver fibrosis, lung injury, and autoimmune diseases. Despite becoming exciting targets for diagnosing and treating these diseases, the role of these enzymes in the regulation of immune and inflammatory response is still unclear. Here, we review the underlying mechanisms through which KDMs regulate immune-related pathways and inflammatory responses. In addition, we also discuss the future applications of KDMs inhibitors in immune and inflammatory diseases.
Identifiants
pubmed: 37353521
doi: 10.1038/s41420-023-01489-9
pii: 10.1038/s41420-023-01489-9
pmc: PMC10290154
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
188Subventions
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 82172301
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 81971966
Informations de copyright
© 2023. The Author(s).
Références
FASEB J. 2015 May;29(5):1830-41
pubmed: 25609425
Cell Mol Immunol. 2020 Aug;17(8):834-842
pubmed: 31197256
Nat Rev Gastroenterol Hepatol. 2021 Mar;18(3):151-166
pubmed: 33128017
Epigenomics. 2015;7(4):609-26
pubmed: 26111032
Cell Mol Immunol. 2019 Aug;16(8):694-705
pubmed: 29844591
J Immunol. 2020 Aug 15;205(4):987-993
pubmed: 32690657
Clin Cancer Res. 2021 Jan 15;27(2):438-446
pubmed: 33046517
EMBO J. 2020 Apr 1;39(7):e103949
pubmed: 32125007
Immunity. 2014 Mar 20;40(3):342-54
pubmed: 24656046
Inflamm Res. 2020 Jul;69(7):657-666
pubmed: 32394143
Immunology. 2016 Apr;147(4):476-87
pubmed: 26749286
Metabolism. 2022 Oct;135:155271
pubmed: 35914619
Immunol Rev. 2022 Jan;305(1):90-110
pubmed: 34908173
Nature. 2006 Feb 16;439(7078):811-6
pubmed: 16362057
Nucleic Acids Res. 2018 Jun 20;46(11):5547-5560
pubmed: 29718303
Antioxidants (Basel). 2021 Dec 27;11(1):
pubmed: 35052555
Cell Rep. 2020 Oct 6;33(1):108219
pubmed: 33027660
Nat Commun. 2015 Sep 02;6:8152
pubmed: 26328764
Hautarzt. 1969 Aug;20(8):369-70
pubmed: 5359994
Theranostics. 2021 Jan 1;11(1):361-378
pubmed: 33391480
J Autoimmun. 2016 Dec;75:105-117
pubmed: 27528513
J Biol Chem. 2016 Feb 5;291(6):2631-46
pubmed: 26645689
J Mol Cell Biol. 2015 Dec;7(6):505-16
pubmed: 25840993
Sci Transl Med. 2020 Sep 9;12(560):
pubmed: 32908002
Semin Nephrol. 2013 Jul;33(4):375-82
pubmed: 24011579
Nat Immunol. 2022 Aug;23(8):1148-1156
pubmed: 35879449
PLoS Pathog. 2015 Jun 17;11(6):e1004978
pubmed: 26083387
Braz J Med Biol Res. 2013 Sep;46(9):739-45
pubmed: 24068189
Clin Rev Allergy Immunol. 2010 Aug;39(1):62-77
pubmed: 19644776
Nat Immunol. 2017 Feb;18(2):184-195
pubmed: 27992400
J Immunol. 2021 Apr 1;206(7):1425-1435
pubmed: 33597151
J Exp Med. 2013 Jul 1;210(7):1369-87
pubmed: 23752229
Nat Rev Genet. 2023 Jan;24(1):21-43
pubmed: 35840754
Cell Signal. 2014 Sep;26(9):1783-91
pubmed: 24703936
J Mol Med (Berl). 2014 Oct;92(10):1035-43
pubmed: 24925089
Genes Dev. 2010 Mar 1;24(5):432-7
pubmed: 20194436
Nat Rev Immunol. 2012 Dec;12(12):845-57
pubmed: 23154222
Phys Chem Chem Phys. 2022 Jun 8;24(22):13806-13823
pubmed: 35612608
PLoS Biol. 2018 Aug 6;16(8):e2006134
pubmed: 30080846
Sci China Life Sci. 2022 Mar;65(3):588-603
pubmed: 34125371
Cell. 2010 Mar 19;140(6):805-20
pubmed: 20303872
Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9235-40
pubmed: 24928520
Elife. 2022 Mar 28;11:
pubmed: 35343899
Sci Rep. 2021 Jan 14;11(1):1342
pubmed: 33446666
Cell Death Dis. 2022 Jun 13;13(6):547
pubmed: 35697678
Cell Death Dis. 2019 Mar 20;10(4):278
pubmed: 30894511
Biochem Biophys Res Commun. 2019 Jun 18;514(1):16-23
pubmed: 31014673
Signal Transduct Target Ther. 2022 Sep 1;7(1):304
pubmed: 36050314
J Autoimmun. 2017 Jun;80:85-94
pubmed: 28284523
Proc Natl Acad Sci U S A. 2022 Aug 23;119(34):e2200753119
pubmed: 35969736
Immunity. 2015 Oct 20;43(4):703-14
pubmed: 26431949
BMC Cancer. 2021 May 29;21(1):635
pubmed: 34051747
Annu Rev Immunol. 2007;25:297-336
pubmed: 17150027
Cell Rep. 2016 Aug 16;16(7):1829-37
pubmed: 27498878
J Biol Chem. 2011 Dec 2;286(48):41616-41625
pubmed: 21914792
Theranostics. 2019 Oct 21;9(26):8277-8293
pubmed: 31754396
J Am Chem Soc. 2010 May 19;132(19):6827-33
pubmed: 20415477
PLoS Pathog. 2022 Feb 24;18(2):e1010325
pubmed: 35202434
Cells. 2021 Apr 27;10(5):
pubmed: 33925695
Cell Rep. 2015 Dec 15;13(10):2219-31
pubmed: 26673323
Mol Cell. 2012 Oct 12;48(1):28-38
pubmed: 22921934
J Cell Physiol. 2022 Jan;237(1):992-1012
pubmed: 34520565
Biochem Biophys Res Commun. 2012 May 18;421(4):665-70
pubmed: 22542627
Immunity. 2022 May 10;55(5):847-861.e10
pubmed: 35545033
J Hepatol. 2022 Jul;77(1):15-28
pubmed: 35167910
Pharmacol Res. 2022 Jan;175:105958
pubmed: 34718134
Int Rev Cell Mol Biol. 2018;341:125-168
pubmed: 30262031
Exp Mol Med. 2019 Jun 20;51(6):1-17
pubmed: 31221981
Clin Rev Allergy Immunol. 2022 Aug;63(1):36-54
pubmed: 34417936
Proc Natl Acad Sci U S A. 2020 Mar 17;117(11):6056-6066
pubmed: 32123118
J Exp Med. 2015 Mar 9;212(3):297-306
pubmed: 25687282
J Clin Invest. 2019 Aug 12;129(9):3852-3863
pubmed: 31403472
Nat Rev Immunol. 2019 Jul;19(7):417-432
pubmed: 30918351
Cells. 2022 Jul 03;11(13):
pubmed: 35805191
Nature. 2012 Aug 16;488(7411):404-8
pubmed: 22842901
J Exp Clin Cancer Res. 2022 Jun 2;41(1):191
pubmed: 35655230
J Immunol. 2019 Feb 15;202(4):1088-1098
pubmed: 30626691
Blood. 2009 Oct 8;114(15):3244-54
pubmed: 19567879
Annu Rev Physiol. 2017 Feb 10;79:541-566
pubmed: 27813830
Oncogene. 2020 Oct;39(41):6451-6467
pubmed: 32879443
FASEB J. 2018 Feb;32(2):552-567
pubmed: 28970247
Cell. 2007 Sep 21;130(6):1083-94
pubmed: 17825402
CNS Drugs. 2021 Mar;35(3):331-344
pubmed: 33755924
Int J Clin Exp Pathol. 2018 Jan 01;11(1):333-341
pubmed: 31938116
Stem Cells. 2015 Aug;33(8):2523-36
pubmed: 25827480
Front Immunol. 2022 Mar 15;13:818070
pubmed: 35371061
Elife. 2022 Sep 07;11:
pubmed: 36069787
Sci Rep. 2019 Dec 5;9(1):18771
pubmed: 31801957
Pharmaceutics. 2022 Jul 06;14(7):
pubmed: 35890315
Semin Cancer Biol. 2018 Dec;53:178-188
pubmed: 30081230
Front Nutr. 2022 Jul 04;9:916690
pubmed: 35859758
Nat Rev Cancer. 2022 Oct;22(10):557-575
pubmed: 35879429
Int J Mol Sci. 2022 Aug 20;23(16):
pubmed: 36012674
Nat Metab. 2022 May;4(5):559-574
pubmed: 35606596
Nucleic Acids Res. 2017 Apr 20;45(7):3800-3811
pubmed: 28100697
World J Gastroenterol. 2019 Jun 21;25(23):2863-2877
pubmed: 31249445
Adv Drug Deliv Rev. 2017 Nov 1;121:27-42
pubmed: 28506744
Sci Immunol. 2022 Aug 5;7(74):eabj9123
pubmed: 35930654
J Hematol Oncol. 2019 Dec 4;12(1):129
pubmed: 31801559
Clin Exp Allergy. 2018 Nov;48(11):1439-1452
pubmed: 30084510
Nat Immunol. 2022 Jun;23(6):848-860
pubmed: 35624210
Nat Commun. 2014 Dec 22;5:5780
pubmed: 25531312
Protein Cell. 2019 Apr;10(4):285-294
pubmed: 30357595
Clin Transl Med. 2021 Sep;11(9):e424
pubmed: 34586733
Immunity. 2009 Jan 16;30(1):155-67
pubmed: 19144320
FASEB J. 2020 Mar;34(3):4107-4119
pubmed: 31971317
J Immunother Cancer. 2022 Feb;10(2):
pubmed: 35121645
J Immunol. 2021 May 1;206(9):2170-2183
pubmed: 33863789
Nat Microbiol. 2021 Feb;6(2):257-269
pubmed: 33349663
Adv Mater. 2022 Jul;34(30):e2202715
pubmed: 35671349
FASEB J. 2018 Jul;32(7):4031-4042
pubmed: 29481307
Cell Mol Immunol. 2022 Nov;19(11):1215-1234
pubmed: 36220996
Signal Transduct Target Ther. 2022 Nov 7;7(1):374
pubmed: 36336680
Nat Rev Mol Cell Biol. 2012 Apr 04;13(5):297-311
pubmed: 22473470
Proc Natl Acad Sci U S A. 2022 Jan 18;119(3):
pubmed: 35022243
Animals (Basel). 2020 Sep 10;10(9):
pubmed: 32927884
mBio. 2021 Dec 21;12(6):e0224321
pubmed: 34781735
Biochem Genet. 2021 Dec;59(6):1427-1440
pubmed: 33909202
Med Res Rev. 2015 Sep;35(5):1032-71
pubmed: 25990136
Eur J Med Chem. 2022 Jan 15;228:114042
pubmed: 34915312
J Physiol. 2019 Mar;597(6):1643-1660
pubmed: 30516825
Immunity. 2021 Nov 9;54(11):2465-2480.e5
pubmed: 34706222
Cell Rep. 2016 Apr 12;15(2):288-99
pubmed: 27050510
Immunity. 2022 Sep 13;55(9):1564-1580
pubmed: 36103853
J Exp Clin Cancer Res. 2022 Mar 31;41(1):119
pubmed: 35361234
Cancers (Basel). 2022 Jul 04;14(13):
pubmed: 35805040
Exp Cell Res. 2021 Sep 15;406(2):112762
pubmed: 34352276
Nat Immunol. 2010 Oct;11(10):936-44
pubmed: 20729857
Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):E244-E252
pubmed: 29263096
Cell Res. 2020 Jun;30(6):465-474
pubmed: 32367041
Hepatol Commun. 2022 Aug;6(8):2042-2057
pubmed: 35468265
J Med Chem. 2020 Dec 10;63(23):14522-14529
pubmed: 33034194
J Biol Chem. 2022 Jun;298(6):102017
pubmed: 35526564
Cell Rep. 2020 Nov 3;33(5):108333
pubmed: 33147467
Exp Ther Med. 2021 Mar;21(3):180
pubmed: 33488789
J Allergy Clin Immunol. 2020 Dec;146(6):1295-1301
pubmed: 33002516
Cancer Immunol Immunother. 2022 Oct;71(10):2449-2467
pubmed: 35254477
J Immunol. 2021 Sep 15;207(6):1599-1615
pubmed: 34408010
Int J Mol Sci. 2022 Aug 18;23(16):
pubmed: 36012577
Exp Cell Res. 2020 Oct 15;395(2):112173
pubmed: 32679234
Biochem Pharmacol. 2022 Sep;203:115165
pubmed: 35803318
Am J Respir Cell Mol Biol. 2016 Jul;55(1):58-71
pubmed: 26699812
Front Immunol. 2021 Jun 14;12:625732
pubmed: 34194422
Cell Biosci. 2017 May 17;7:25
pubmed: 28529687
Oncotarget. 2017 Jul 25;8(30):48938-48947
pubmed: 28430662
Acta Pharm Sin B. 2022 May;12(5):2300-2314
pubmed: 35646542
Nat Immunol. 2017 Sep;18(9):985-994
pubmed: 28714978
Annu Rev Immunol. 2022 Apr 26;40:195-220
pubmed: 35044795
Mol Cell. 2012 May 25;46(4):408-23
pubmed: 22633489
Nat Commun. 2016 Nov 14;7:13387
pubmed: 27841353
Front Immunol. 2021 May 31;12:667664
pubmed: 34135896
Cell. 2022 Feb 17;185(4):614-629.e21
pubmed: 35148840
Cell Mol Immunol. 2022 Mar;19(3):337-351
pubmed: 34697412
Nat Rev Gastroenterol Hepatol. 2022 Apr;19(4):239-256
pubmed: 34837066
J Biol Chem. 2008 Sep 26;283(39):26771-81
pubmed: 18650421
Cell Mol Immunol. 2019 May;16(5):430-441
pubmed: 30778167
J Biol Chem. 2022 May;298(5):101816
pubmed: 35278430
J Immunol Res. 2021 Feb 22;2021:6629844
pubmed: 33688506
Int Immunopharmacol. 2022 Sep;110:109000
pubmed: 35777266
J Neurochem. 2012 Jul;122(2):272-82
pubmed: 22578249
Nat Struct Mol Biol. 2010 Apr;17(4):445-50
pubmed: 20208542
Cell Death Differ. 2021 Jun;28(6):1880-1899
pubmed: 33462408
Mol Cancer. 2022 Nov 1;21(1):206
pubmed: 36319998
Front Immunol. 2020 Sep 17;11:2196
pubmed: 33042135
Eur J Med Chem. 2022 Mar 5;231:114143
pubmed: 35101649
Mol Cell. 2010 Apr 23;38(2):179-90
pubmed: 20417597
Life Sci. 2019 Dec 15;239:116868
pubmed: 31682847
Cell Death Differ. 2017 May;24(5):819-831
pubmed: 28234358
Oncogene. 2011 Apr 28;30(17):2037-43
pubmed: 21242977
Adv Sci (Weinh). 2020 Oct 11;7(22):2002680
pubmed: 33240782
Int Immunopharmacol. 2021 Feb;91:107324
pubmed: 33385711
Theranostics. 2021 Jan 1;11(6):2706-2721
pubmed: 33456568
EBioMedicine. 2019 Jan;39:472-483
pubmed: 30527625
Front Immunol. 2022 Apr 26;13:881396
pubmed: 35558079
Nat Rev Immunol. 2022 Feb;22(2):97-111
pubmed: 34099898
J Biol Chem. 2018 Feb 16;293(7):2422-2437
pubmed: 29301935
Cell Rep. 2021 Mar 9;34(10):108833
pubmed: 33691111
Histochem Cell Biol. 2022 Jan;157(1):7-25
pubmed: 34599660
Nat Immunol. 2022 Sep;23(9):1379-1392
pubmed: 36002648
J Immunol. 2020 May 15;204(10):2762-2778
pubmed: 32277055
Genes Dev. 2008 May 1;22(9):1115-40
pubmed: 18451103
J Immunol. 2020 Jan 1;204(1):159-168
pubmed: 31748348
J Allergy Clin Immunol. 2022 Feb;149(2):488-516.e9
pubmed: 34848210
Mol Ther. 2022 Dec 7;30(12):3714-3728
pubmed: 35923112
Life Sci. 2019 Sep 15;233:116696
pubmed: 31351969
J Clin Oncol. 2020 Dec 20;38(36):4260-4273
pubmed: 33052756
Cell Rep. 2022 Apr 19;39(3):110719
pubmed: 35443173
Cell Death Differ. 2022 Jul;29(7):1349-1363
pubmed: 34999729
Cell Death Differ. 2022 Dec;29(12):2519-2530
pubmed: 35831623
J Immunol. 2018 Nov 1;201(9):2799-2811
pubmed: 30232138
Nat Rev Drug Discov. 2022 Nov;21(11):799-820
pubmed: 35974096
Free Radic Biol Med. 2022 Feb 1;179:328-336
pubmed: 33359432
Immunity. 2022 Jan 11;55(1):14-30
pubmed: 35021054
Oncogene. 2020 Apr;39(16):3336-3353
pubmed: 32094404
Front Immunol. 2021 Dec 23;12:767175
pubmed: 35003081
Nat Rev Immunol. 2017 Feb;17(2):83-96
pubmed: 28044057
Nat Commun. 2022 Jan 10;13(1):78
pubmed: 35013257
Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):46-51
pubmed: 20080798
Eur J Pharmacol. 2022 Oct 15;932:175227
pubmed: 36007605
PLoS Pathog. 2021 Mar 31;17(3):e1009476
pubmed: 33788902
Cancer Immunol Res. 2022 Aug 3;10(8):1028-1038
pubmed: 35726891
Mol Cell. 2018 Feb 1;69(3):398-411.e6
pubmed: 29395062
Allergy. 2022 Jul;77(7):2131-2146
pubmed: 35038351
FASEB J. 2022 Jan;36(1):e22122
pubmed: 34958158
Nat Commun. 2013;4:2035
pubmed: 23792809
FASEB J. 2019 Jan;33(1):327-338
pubmed: 30001167
Cell Mol Immunol. 2022 Jun;19(6):715-725
pubmed: 35459853
J Exp Med. 2021 Dec 6;218(12):
pubmed: 34726730
Nat Immunol. 2019 Jan;20(1):86-96
pubmed: 30538335