Large library docking for novel SARS-CoV-2 main protease non-covalent and covalent inhibitors.
SARS-COV-2
discoverydockinganti-viral
major protease
structure-based inhibitor
Journal
Protein science : a publication of the Protein Society
ISSN: 1469-896X
Titre abrégé: Protein Sci
Pays: United States
ID NLM: 9211750
Informations de publication
Date de publication:
08 2023
08 2023
Historique:
revised:
29
05
2023
received:
01
02
2023
accepted:
21
06
2023
pmc-release:
01
08
2024
medline:
31
7
2023
pubmed:
24
6
2023
entrez:
24
6
2023
Statut:
ppublish
Résumé
Antiviral therapeutics to treat SARS-CoV-2 are needed to diminish the morbidity of the ongoing COVID-19 pandemic. A well-precedented drug target is the main viral protease (M
Identifiants
pubmed: 37354015
doi: 10.1002/pro.4712
pmc: PMC10364469
doi:
Substances chimiques
3C-like proteinase, SARS-CoV-2
EC 3.4.22.-
Protease Inhibitors
0
Viral Nonstructural Proteins
0
Antiviral Agents
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e4712Subventions
Organisme : NIGMS NIH HHS
ID : T32 GM145460
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI163912
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM122481
Pays : United States
Organisme : NIH HHS
ID : R35GM122481
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI171110
Pays : United States
Organisme : NIH HHS
ID : R21AI163912
Pays : United States
Organisme : NIAID NIH HHS
ID : U19AI135972
Pays : United States
Organisme : NIAID NIH HHS
ID : U19AI171110
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI135972
Pays : United States
Organisme : NIAID NIH HHS
ID : 75N93021C00014
Pays : United States
Informations de copyright
© 2023 The Protein Society.
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