PD-L1 ImmunoPET on the basis of Avidin/Biotin pre-targeted cancer imaging.

Mice Animals Biotin Avidin B7-H1 Antigen / metabolism Gallium Radioisotopes Positron-Emission Tomography / methods Colonic Neoplasms Radiopharmaceuticals Cell Line, Tumor Tumor Microenvironment
Avidin/Biotin Colon cancer ImmunoPET PD-L1 Pre-targeting

Journal

Biochemical and biophysical research communications
ISSN: 1090-2104
Titre abrégé: Biochem Biophys Res Commun
Pays: United States
ID NLM: 0372516

Informations de publication

Date de publication:
17 09 2023
Historique:
received: 10 05 2023
revised: 20 05 2023
accepted: 17 06 2023
medline: 1 8 2023
pubmed: 25 6 2023
entrez: 24 6 2023
Statut: ppublish

Résumé

This study aimed to establish the radio-immune imaging protocol on the basis of Avidin/Biotin system. The programmed death-ligand 1 (PD-L1) antibody (Atezolizumab) was employed as the primary molecule in targeting PD-L1, and the two-step strategy, consisting of the first injection of Avidin-conjugated PD-L1 monoclonal antibody (Atezolizumab) and the second injection of 7.4 MBq

Identifiants

DOI: 10.1016/j.bbrc.2023.06.059 PMID: 37354656
pubmed: 37354656
pii: S0006-291X(23)00814-8
doi: 10.1016/j.bbrc.2023.06.059
pii:
doi:

Substances chimiques

Biotin 6SO6U10H04
Avidin 1405-69-2
CD274 protein, human 0
B7-H1 Antigen 0
Gallium Radioisotopes 0
Radiopharmaceuticals 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

23-28

Informations de copyright

Copyright © 2023 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare no conflict of interest. The authors declare no conflict of interest.

Auteurs

Zhongqiu Guo (Z)

Department of Nuclear Medicine, Shanghai Changhai Hospital, Shanghai, 200433, China.

Lizhi Zhu (L)

Department of Nuclear Medicine, Shanghai Changhai Hospital, Shanghai, 200433, China.

Wen Xu (W)

Department of Radiology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Hubei, 441021, China.

Xiu Luo (X)

Department of Nuclear Medicine, Shanghai Changhai Hospital, Shanghai, 200433, China.

Hui Chen (H)

Department of Radiology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Hubei, 441021, China. Electronic address: ch2xf@163.com.

Xiao Li (X)

Department of Nuclear Medicine, Shanghai Changhai Hospital, Shanghai, 200433, China; Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800, China. Electronic address: lixiao_nm@smmu.edu.cn.

Changjing Zuo (C)

Department of Nuclear Medicine, Shanghai Changhai Hospital, Shanghai, 200433, China. Electronic address: changjing.zuo@qq.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › PD-L1 ImmunoPET on the basis of Avidin/Biotin...
questionsmedicales.fr › Eucaryotes › Animaux › PD-L1 ImmunoPET on the basis of Avidin/Biotin...
questionsmedicales.fr › Enzymes et coenzymes › Coenzymes › Biotine › PD-L1 ImmunoPET on the basis of Avidin/Biotin...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Glycoprotéines › Avidine › PD-L1 ImmunoPET on the basis of Avidin/Biotin...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Antigènes B7 › Antigène CD274 › PD-L1 ImmunoPET on the basis of Avidin/Biotin...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Gallium › Isotopes du gallium › Radio-isotopes du gallium › PD-L1 ImmunoPET on the basis of Avidin/Biotin...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › PD-L1 ImmunoPET on the basis of Avidin/Biotin...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Tumeurs de l'intestin › Tumeurs du côlon › PD-L1 ImmunoPET on the basis of Avidin/Biotin...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Indicateurs et réactifs › Radiopharmaceutiques › PD-L1 ImmunoPET on the basis of Avidin/Biotin...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › PD-L1 ImmunoPET on the basis of Avidin/Biotin...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › PD-L1 ImmunoPET on the basis of Avidin/Biotin...