Dopamine receptor-mediated roles on retinal ganglion cell hyperexcitability and injury in experimental glaucoma.

Rats Animals Retinal Ganglion Cells / metabolism Sulpiride / metabolism Rats, Sprague-Dawley Glaucoma / metabolism Ocular Hypertension / metabolism Receptors, Dopamine D1 / metabolism Disease Models, Animal
D1 receptors D2 receptors Dopamine Glaucoma Hyperexcitability Na(+) currents Outward K(+) currents RGC injury

Journal

Cellular signalling
ISSN: 1873-3913
Titre abrégé: Cell Signal
Pays: England
ID NLM: 8904683

Informations de publication

Date de publication:
09 2023
Historique:
received: 20 11 2022
revised: 14 06 2023
accepted: 21 06 2023
medline: 28 7 2023
pubmed: 25 6 2023
entrez: 24 6 2023
Statut: ppublish

Résumé

Extraordinary excitability (hyperexcitability) is closely related to retinal ganglion cell (RGC) injury in glaucoma. Dopamine (DA) and its receptors are involved in modulating RGC excitability. We investigated how DA system affects RGC injury in chronic ocular hypertension (COH) experimental glaucoma model. Western blotting and immunohistochemistry results revealed that expression of DA D2-like receptor (D2R) in RGCs was increased in COH retinas. Patch-clamp recordings showed that outward K

Identifiants

DOI: 10.1016/j.cellsig.2023.110781 PMID: 37354963
pubmed: 37354963
pii: S0898-6568(23)00195-X
doi: 10.1016/j.cellsig.2023.110781
pii:
doi:

Substances chimiques

Sulpiride 7MNE9M8287
Receptors, Dopamine D1 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

110781

Informations de copyright

Copyright © 2023 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no competing interests.

Auteurs

Ning Yin (N)

State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China.

Hong-Ning Wang (HN)

State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China.

Wen-Wen Ding (WW)

State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China.

Han Zhou (H)

State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China.

Shu-Ying Li (SY)

State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China.

Yanying Miao (Y)

State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China.

Fang Li (F)

State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China.

Bo Lei (B)

Institutes of Neuroscience and Third Affiliated Hospital, Henan Provincial People's Hospital, Henan Eye Institute, Henan Eye Hospital, People's Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou 450003, China.

Zhongfeng Wang (Z)

State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China. Electronic address: zfwang@fudan.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Dopamine receptor-mediated roles on retinal...
questionsmedicales.fr › Eucaryotes › Animaux › Dopamine receptor-mediated roles on retinal...
questionsmedicales.fr › Cellules › Neurones › Neurones afférents › Neurones rétiniens › Cellules ganglionnaires rétiniennes › Dopamine receptor-mediated roles on retinal...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Benzoates › Benzamides › Sulpiride › Dopamine receptor-mediated roles on retinal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Sprague-Dawley › Dopamine receptor-mediated roles on retinal...
questionsmedicales.fr › Maladies de l'oeil › Hypertension oculaire › Glaucome › Dopamine receptor-mediated roles on retinal...
questionsmedicales.fr › Maladies de l'oeil › Hypertension oculaire › Dopamine receptor-mediated roles on retinal...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs catécholaminergiques › Récepteurs dopaminergiques › Récepteur dopamine D1 › Dopamine receptor-mediated roles on retinal...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Dopamine receptor-mediated roles on retinal...