Using the Infant Sibling-Design to Explore Associations Between Autism and ADHD Traits in Probands and Temperament in the Younger Siblings.
Attention-deficit/hyperactivity disorder
Autism spectrum disorder
Developmental substructure
Etiology
Temperament
Journal
Journal of autism and developmental disorders
ISSN: 1573-3432
Titre abrégé: J Autism Dev Disord
Pays: United States
ID NLM: 7904301
Informations de publication
Date de publication:
24 Jun 2023
24 Jun 2023
Historique:
accepted:
09
06
2023
medline:
25
6
2023
pubmed:
25
6
2023
entrez:
24
6
2023
Statut:
aheadofprint
Résumé
The purpose of the current study was to use the infant sibling design to explore whether proband traits of autism and ADHD could provide information about their infant sibling's temperament. This could help us to gain information about the extent to which infant temperament traits are differentially associated with autism and ADHD traits. We used parent-ratings of autistic traits and ADHD traits (CRS-3) in older siblings diagnosed with autism (age range 4 to 19 years), and their infant siblings' temperament traits (IBQ) at 9 months of age in 216 sibling pairs from two sites (BASIS, UK, and EASE, Sweden) to examine associations across siblings. We found specific, but modest, associations across siblings after controlling for sex, age, developmental level and site. Proband autistic traits were specifically related to low levels of approach in the infant siblings, with infant developmental level explaining part of the variance in infant approach. Proband ADHD traits were specifically related to high levels of infant activity even after controlling for covariates. Our findings suggest that proband traits of autism and ADHD carry information for infant sibling's temperament, indicating that inherited liability may influence early emerging behaviours in infant siblings. The impact of sex, age, developmental level and site are discussed.
Identifiants
pubmed: 37355531
doi: 10.1007/s10803-023-06047-x
pii: 10.1007/s10803-023-06047-x
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Medical Research Council
ID : MR/K021389/1
Pays : United Kingdom
Organisme : MRF
ID : MR/K021389/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0701484
Pays : United Kingdom
Organisme : MQ: Transforming Mental Health
ID : MQ14PP83
Pays : United Kingdom
Organisme : MRF
ID : G0701484
Pays : United Kingdom
Informations de copyright
© 2023. The Author(s).
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