On the origin and development of glioblastoma: multifaceted role of perivascular mesenchymal stromal cells.
Glioblastoma
Gliomagenesis
Mesenchymal stromal cells
Microenvironment
Neural crest
Pericytes
Perivascular fibroblasts
Journal
Acta neuropathologica communications
ISSN: 2051-5960
Titre abrégé: Acta Neuropathol Commun
Pays: England
ID NLM: 101610673
Informations de publication
Date de publication:
24 06 2023
24 06 2023
Historique:
received:
11
04
2023
accepted:
18
06
2023
medline:
26
6
2023
pubmed:
25
6
2023
entrez:
24
6
2023
Statut:
epublish
Résumé
Glioblastoma, IDH wild-type is the most common and aggressive form of glial tumors. The exact mechanisms of glioblastoma oncogenesis, including the identification of the glioma-initiating cell, are yet to be discovered. Recent studies have led to the hypothesis that glioblastoma arises from neural stem cells and glial precursor cells and that cell lineage constitutes a key determinant of the glioblastoma molecular subtype. These findings brought significant advancement to the comprehension of gliomagenesis. However, the cellular origin of glioblastoma with mesenchymal molecular features remains elusive. Mesenchymal stromal cells emerge as potential glioblastoma-initiating cells, especially with regard to the mesenchymal molecular subtype. These fibroblast-like cells, which derive from the neural crest and reside in the perivascular niche, may underlie gliomagenesis and exert pro-tumoral effects within the tumor microenvironment. This review synthesizes the potential roles of mesenchymal stromal cells in the context of glioblastoma and provides novel research avenues to better understand this lethal disease.
Identifiants
pubmed: 37355636
doi: 10.1186/s40478-023-01605-x
pii: 10.1186/s40478-023-01605-x
pmc: PMC10290416
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
104Subventions
Organisme : Conseil Régional de La Réunion
ID : 2017-1198-0002583
Organisme : Conseil Régional de La Réunion
ID : 2019-2211-0022768
Informations de copyright
© 2023. The Author(s).
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