Acute muscle mass loss was alleviated with HMGB1 neutralizing antibody treatment in severe burned rats.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
24 06 2023
24 06 2023
Historique:
received:
21
03
2023
accepted:
22
06
2023
medline:
26
6
2023
pubmed:
25
6
2023
entrez:
24
6
2023
Statut:
epublish
Résumé
Burn injury is associated with muscle wasting, though the involved signaling mechanisms are not well understood. In this study, we aimed to examine the role of high mobility group box 1 (HMGB1) in signaling hyper-inflammation and consequent skeletal muscle impairment after burn. Sprague Dawley rats were randomly assigned into three groups: (1) sham burn, (2) burn, (3) burn/treatment. Animals in group 2 and group 3 received scald burn on 30% of total body surface area (TBSA) and immediately treated with chicken IgY and anti-HMGB1 antibody, respectively. Muscle tissues and other samples were collected at 3-days after burn. Body mass and wet/dry weights of the hind limb muscles (total and individually) were substantially decreased in burn rats. Acute burn provoked the mitochondrial stress and cell death and enhanced the protein ubiquitination and LC3A/B levels that are involved in protein degradation in muscle tissues. Further, an increase in muscle inflammatory infiltrate associated with increased differentiation, maturation and proinflammatory activation of bone marrow myeloid cells and αβ CD4
Identifiants
pubmed: 37355693
doi: 10.1038/s41598-023-37476-4
pii: 10.1038/s41598-023-37476-4
pmc: PMC10290662
doi:
Substances chimiques
HMGB1 Protein
0
Antibodies, Neutralizing
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
10250Subventions
Organisme : NIAID NIH HHS
ID : R21 AI151305
Pays : United States
Organisme : NIAID NIH HHS
ID : R44 AI172437
Pays : United States
Informations de copyright
© 2023. The Author(s).
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