Bone Marrow-Derived Mononuclear Cells in the Treatment of Neurological Diseases: Knowns and Unknowns.

Acosta SA, Tajiri N, Hoover J, Kaneko Y, Borlongan CVJS (2015) Intravenous bone marrow stem cell grafts preferentially migrate to spleen and abrogate chronic inflammation in stroke. Stroke 46(9):2616–2627

pubmed: 26219646 pmcid: 4542567 doi: 10.1161/STROKEAHA.115.009854

Akiyama Y, Radtke C, Honmou O, Kocsis JDJG (2002) Remyelination of the spinal cord following intravenous delivery of bone marrow cells. Glia 39(3):229–236

pubmed: 12203389 pmcid: 2605380 doi: 10.1002/glia.10102

Alvarez-Dolado M, Pardal R, Garcia-Verdugo JM, Fike JR, Lee HO, Pfeffer K, Lois C, Morrison SJ, Alvarez-Buylla AJN (2003) Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes. Nature 425(6961):968–973

pubmed: 14555960 doi: 10.1038/nature02069

Amar AP, Zlokovic BV, Apuzzo MLJN (2003) Endovascular restorative neurosurgery: a novel concept for molecular and cellular therapy of the nervous system. Neurosurgery 52(2):402–413

pubmed: 12535371 doi: 10.1227/01.NEU.0000043698.86548.A0

Anderson L, Burnstein RM, He X, Luce R, Furlong R, Foltynie T, Sykacek P, Menon DK (2007) Gene expression changes in long term expanded human neural progenitor cells passaged by chopping lead to loss of neurogenic potential in vivo. Exp Neurol 204(2):512–524

pubmed: 17306795 doi: 10.1016/j.expneurol.2006.12.025

Andrzejewska A, Dabrowska S, Lukomska B, Janowski MJAS (2021) Mesenchymal stem cells for neurological disorders. Adv Sci 8(7):2002944

doi: 10.1002/advs.202002944

Arai K, Harada Y, Tomiyama H, Michishita M, Kanno N, Yogo T, Suzuki Y, Hara Y (2016) Evaluation of the survival of bone marrow-derived mononuclear cells and the growth factors produced upon intramedullary transplantation in rat models of acute spinal cord injury. Res Vet Sci 107:88–94. https://doi.org/10.1016/j.rvsc.2016.05.011

doi: 10.1016/j.rvsc.2016.05.011 pubmed: 27473980

Asahara T, Murohara T, Sullivan A, Silver M, van der Zee R, Li T, Witzenbichler B, Schatteman G, Isner JMJS (1997) Isolation of putative progenitor endothelial cells for angiogenesis. Science 275(5302):964–966

pubmed: 9020076 doi: 10.1126/science.275.5302.964

Bakshi A, Hunter C, Swanger S, Lepore A, Fischer I (2004) Minimally invasive delivery of stem cells for spinal cord injury: advantages of the lumbar puncture technique. J Neurosurg 1(3):330–337

Barbosa da Fonseca LM, Gutfilen B, Rosado de Castro PH, Battistella V, Goldenberg RC, Kasai-Brunswick T, Chagas CL, Wajnberg E, Maiolino A, Salles Xavier S, Andre C, Mendez-Otero R, de Freitas GR (2010) Migration and homing of bone-marrow mononuclear cells in chronic ischemic stroke after intra-arterial injection. Exp Neurol 221(1):122–128. https://doi.org/10.1016/j.expneurol.2009.10.010

doi: 10.1016/j.expneurol.2009.10.010 pubmed: 19853605

Battistella V, de Freitas GR, da Fonseca LMB, Mercante D, Gutfilen B, Goldenberg RC, Vieira Dias J, Kasai-Brunswick TH, Wajnberg E, Rosado-de-Castro P (2011) Safety of autologous bone marrow mononuclear cell transplantation in patients with nonacute ischemic stroke. Regen Med 6(1):45–52

pubmed: 21175286 doi: 10.2217/rme.10.97

Beausejour C (2007) Bone marrow-derived cells: the influence of aging and cellular senescence. Handb Exp Pharmacol 180:67–88. https://doi.org/10.1007/978-3-540-68976-8_4

doi: 10.1007/978-3-540-68976-8_4

Bedi SS, Walker PA, Shah SK, Jimenez F, Thomas CP, Smith P, Hetz RA, Xue H, Pati S, Dash PK, Cox CS Jr (2013) Autologous bone marrow mononuclear cells therapy attenuates activated microglial/macrophage response and improves spatial learning after traumatic brain injury. J Trauma Acute Care Surg 75(3):410–416. https://doi.org/10.1097/TA.0b013e31829617c6

doi: 10.1097/TA.0b013e31829617c6 pubmed: 23928737 pmcid: 4086922

Bhasin A, Srivastava M, Bhatia R, Mohanty S, Kumaran S, Bose SJ, Medicine R (2012) Autologous intravenous mononuclear stem cell therapy in chronic ischemic stroke. J Stem Cells Regen Med 8(3):181

pubmed: 24693196 pmcid: 3908296 doi: 10.46582/jsrm.0803011

Bhasin A, Srivastava MVP, Mohanty S, Vivekanandhan S, Sharma S, Kumaran S, Bhatia R (2016) Paracrine mechanisms of intravenous bone marrow-derived mononuclear stem cells in chronic ischemic stroke. Cerebrovasc Dis Extra 6(3):107–119. https://doi.org/10.1159/000446404

doi: 10.1159/000446404 pubmed: 27846623 pmcid: 5123023

Blair E, Langdon K, McIntyre S, Lawrence D (2019) Survival and mortality in cerebral palsy: observations to the sixth decade from a data linkage study of a total population register and National Death Index. BMC Neurol 19(1):1–11

doi: 10.1186/s12883-019-1343-1

Blanquer M, Moraleda JM, Iniesta F, Gómez-Espuch J, Meca-Lallana J, Villaverde R, Pérez-Espejo MÁ, Ruíz-López FJ, Garcia Santos JM, Bleda PJ (2012) Neurotrophic bone marrow cellular nests prevent spinal motoneuron degeneration in amyotrophic lateral sclerosis patients: a pilot safety study. Stem Cells 30(6):1277–1285

pubmed: 22415951 doi: 10.1002/stem.1080

Boucherie C, Caumont A-S, Maloteaux J-M, Hermans EJ (2008) In vitro evidence for impaired neuroprotective capacities of adult mesenchymal stem cells derived from a rat model of familial amyotrophic lateral sclerosis (hSOD1G93A). Exp Neurol 212(2):557–561

pubmed: 18539273 doi: 10.1016/j.expneurol.2008.04.030

Brazelton TR, Rossi FM, Keshet GI, Blau HMJS (2000) From marrow to brain: expression of neuronal phenotypes in adult mice. Science 290(5497):1775–1779

pubmed: 11099418 doi: 10.1126/science.290.5497.1775

Callera F, de Melo CMJSC, Development, (2007) Magnetic resonance tracking of magnetically labeled autologous bone marrow CD34+ cells transplanted into the spinal cord via lumbar puncture technique in patients with chronic spinal cord injury: CD34+ cells’ migration into the injured site. Stem Cells Dev 16(3):461–466

pubmed: 17610376 doi: 10.1089/scd.2007.0083

Carneiro GD, Godoy JA, Werneck CC (2015) Differentiation of C57/BL6 mice bone marrow mononuclear cells into early endothelial progenitors cells in different culture conditions. Cell Biol Int 39(10):1138–1150

pubmed: 25965197 doi: 10.1002/cbin.10487

Carness JM, Lenart MJ (2019) Current local anesthetic applications in regional anesthesia. In: Whizar-Lugo VM (ed) Topics in local anesthetics. IntechOpen, London, p 73

Cassidy JD, Carroll LJ, Peloso PM, Borg J, von Holst H, Holm L, Kraus J, Coronado VG, Injury WHOCCTFoMTB (2004) Incidence, risk factors and prevention of mild traumatic brain injury: results of the WHO Collaborating Centre Task Force on Mild Traumatic Brain Injury. J Rehabil Med 36(43 Suppl):28–60. https://doi.org/10.1080/16501960410023732

doi: 10.1080/16501960410023732

CDC (2022) Stroke facts

Chen Q-Q, Yan L, Wang C-Z, Wang W-H, Shi H, Su B-B, Zeng Q-H, Du H-T, Wan JJW (2013) Mesenchymal stem cells alleviate TNBS-induced colitis by modulating inflammatory and autoimmune responses. World J Gastroenterol 19(29):4702

pubmed: 23922467 pmcid: 3732842 doi: 10.3748/wjg.v19.i29.4702

Chen W, Zhang Y, Yang S, Sun J, Qiu H, Hu X, Niu X, Xiao Z, Zhao Y, Zhou YJCT (2020) NeuroRegen scaffolds combined with autologous bone marrow mononuclear cells for the repair of acute complete spinal cord injury: a 3-year clinical study. Cell Transpl. https://doi.org/10.1177/0963689720950637

doi: 10.1177/0963689720950637

Colver A, Fairhurst C, Pharoah PO (2014) Cerebral palsy. Lancet 383(9924):1240–1249. https://doi.org/10.1016/S0140-6736(13)61835-8

doi: 10.1016/S0140-6736(13)61835-8 pubmed: 24268104

Corey S, Bonsack B, Heyck M, Shear A, Sadanandan N, Zhang H, Borlongan CVJBh (2020) Harnessing the anti-inflammatory properties of stem cells for transplant therapy in hemorrhagic stroke. Brain Hemorrhages 1(1):24–33

pubmed: 34056567 pmcid: 8158660 doi: 10.1016/j.hest.2019.12.005

Costa-Ferro ZS, Souza BS, Leal MM, Kaneto CM, Azevedo CM, da Silva IC, Soares MB, Ribeiro-dos-Santos R, DaCosta J (2012) Transplantation of bone marrow mononuclear cells decreases seizure incidence, mitigates neuronal loss and modulates pro-inflammatory cytokine production in epileptic rats. Neurobiol Dis 46(2):302–313

pubmed: 22198377 doi: 10.1016/j.nbd.2011.12.001

Costa-Ferro ZSM, de Oliveira GN, da Silva DV, Marinowic DR, Machado DC, Longo BM, da Costa JCJBS (2020) Intravenous infusion of bone marrow mononuclear cells promotes functional recovery and improves impaired cognitive function via inhibition of Rho guanine nucleotide triphosphatases and inflammatory signals in a model of chronic epilepsy. Brain Struct Funct 225(9):2799–2813

pubmed: 33128125 doi: 10.1007/s00429-020-02159-7

Costa-Ferro ZSM, Doprado-Lima PAS, Onsten GA, Oliveira GN, Brito GC, Ghilardi IM, Dossantos PG, Bertinatto RJ, Dasilva DV, Salamoni SD (2022) Bone marrow mononuclear cell transplant prevents rat depression and modulates inflammatory and neurogenic molecules. Progr Neuro-Psychopharmacol Biol Psychiatry 113:110455

doi: 10.1016/j.pnpbp.2021.110455

Cox CS Jr (2018) Cellular therapy for traumatic neurological injury. Pediatr Res 83(1–2):325–332. https://doi.org/10.1038/pr.2017.253

doi: 10.1038/pr.2017.253 pubmed: 28985200

Cox CS Jr, Baumgartner JE, Harting MT, Worth LL, Walker PA, Shah SK, Ewing-Cobbs L, Hasan KM, Day M-C, Lee DJN (2011) Autologous bone marrow mononuclear cell therapy for severe traumatic brain injury in children. Neurosurgery 68(3):588–600. https://doi.org/10.1227/NEU.0b013e318207734c

doi: 10.1227/NEU.0b013e318207734c pubmed: 21192274

Cox CS Jr, Hetz RA, Liao GP, Aertker BM, Ewing-Cobbs L, Juranek J, Savitz SI, Jackson ML, Romanowska-Pawliczek AM, Triolo FJSC (2017) Treatment of severe adult traumatic brain injury using bone marrow mononuclear cells. Stem Cells 35(4):1065–1079. https://doi.org/10.1002/stem.2538

doi: 10.1002/stem.2538 pubmed: 27800660

Crisostomo PR, Wang Y, Markel TA, Wang M, Lahm T, Meldrum DR (2008) Human mesenchymal stem cells stimulated by TNF-α, LPS, or hypoxia produce growth factors by an NFκB-but not JNK-dependent mechanism. Am J Physiol-Cell Physiol 294(3):C675–C682

pubmed: 18234850 doi: 10.1152/ajpcell.00437.2007

Dabrowska S, Andrzejewska A, Strzemecki D, Muraca M, Janowski M (2019) Human bone marrow mesenchymal stem cell-derived extracellular vesicles attenuate neuroinflammation evoked by focal brain injury in rats. J Neuroinflamm 16:1–15

doi: 10.1186/s12974-019-1602-5

DaCosta JC, Portuguez MW, Marinowic DR, Schilling LP, Torres CM, DaCosta DI, Carrion MJM, Raupp EF, Machado DC, Soder RB (2018) Safety and seizure control in patients with mesial temporal lobe epilepsy treated with regional superselective intra-arterial injection of autologous bone marrow mononuclear cells. J Tissue Eng Regen Med 12(2):e648–e656

pubmed: 27688159 doi: 10.1002/term.2334

Dalic L, Cook MJJ (2016) Managing drug-resistant epilepsy: challenges and solutions. NDT 12:2605

doi: 10.2147/NDT.S84852

Dantzer RJ (2018) Neuroimmune interactions: from the brain to the immune system and vice versa. Physiol Rev 98(1):477–504

pubmed: 29351513 doi: 10.1152/physrev.00039.2016

Darabi S, Tiraihi T, Delshad A, Sadeghizadeh M (2013) A new multistep induction protocol for the transdifferentiation of bone marrow stromal stem cells into GABAergic neuron-like cells. Iran Biomed J 17(1):8

pubmed: 23279829 pmcid: 3600975

De Andres J (2022) Intrathecal drug delivery: advances and applications in the management of chronic pain patient. Front Pain Res 3:74

doi: 10.3389/fpain.2022.900566

Dedeepiya VD, Rao YY, Jayakrishnan GA, Parthiban JK, Baskar S, Manjunath SR, Senthilkumar R, Abraham SJ (2012) Index of CD34+ cells and mononuclear cells in the bone marrow of spinal cord injury patients of different age groups: a comparative analysis. Bone Marrow Res. https://doi.org/10.1155/2012/787414

doi: 10.1155/2012/787414 pubmed: 22830032 pmcid: 3398573

Doeppner TR, Herz J, Görgens A, Schlechter J, Ludwig A-K, Radtke S, de Miroschedji K, Horn PA, Giebel B (2015) Extracellular vesicles improve post-stroke neuroregeneration and prevent postischemic immunosuppression. Stem Cells Transl Med 4(10):1131–1143

pubmed: 26339036 pmcid: 4572905 doi: 10.5966/sctm.2015-0078

Eglitis MA, Mezey ÉJ (1997) Hematopoietic cells differentiate into both microglia and macroglia in the brains of adult mice. Proc Natl Acad Sci USA 94(8):4080–4085

pubmed: 9108108 pmcid: 20571 doi: 10.1073/pnas.94.8.4080

Elia CA, Tamborini M, Rasile M, Desiato G, Marchetti S, Swuec P, Mazzitelli S, Clemente F, Anselmo A, Matteoli MJC (2019) Intracerebral injection of extracellular vesicles from mesenchymal stem cells exerts reduced Aβ plaque burden in early stages of a preclinical model of Alzheimer’s disease. Cells 8(9):1059

pubmed: 31510042 pmcid: 6770482 doi: 10.3390/cells8091059

Engel JJE (2001) A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: report of the ILAE Task Force on Classification and Terminology. Epilepsia 42(6):796–803

pubmed: 11422340 doi: 10.1046/j.1528-1157.2001.10401.x

Finlay-Morreale H (2021) Invasive therapy for children with autism is not justified. Stem Cells Transl Med 10(6):826

pubmed: 34010521 pmcid: 8133346 doi: 10.1002/sctm.20-0434

Fischer UM, Harting MT, Jimenez F, Monzon-Posadas WO, Xue H, Savitz SI, Laine GA, Cox CS (2009) Pulmonary passage is a major obstacle for intravenous stem cell delivery: the pulmonary first-pass effect. Stem Cells Dev 18(5):683–692

pubmed: 19099374 doi: 10.1089/scd.2008.0253

Friedrich MA, Martins MP, Araújo MD, Klamt C, Vedolin L, Garicochea B, Raupp EF, Ammar JSE, Machado DC, Da Costa JC (2012) Intra-arterial infusion of autologous bone marrow mononuclear cells in patients with moderate to severe middle cerebral artery acute ischemic stroke. Cell Transpl 21:13–21

doi: 10.3727/096368912X612512

Gautheron F, Georgievski A, Garrido C, Quéré RJ (2023) Bone marrow-derived extracellular vesicles carry the TGF-β signal transducer Smad2 to preserve hematopoietic stem cells in mice. Cell Death Discov 9(1):117

pubmed: 37019878 pmcid: 10076352 doi: 10.1038/s41420-023-01414-0

Ghafouri-Fard S, Niazi V, Taheri MJH (2021) Contribution of extracellular vesicles in normal hematopoiesis and hematological malignancies. Heliyon 7(1):e06030

pubmed: 33521365 pmcid: 7820922 doi: 10.1016/j.heliyon.2021.e06030

Hardiman O, Van Den Berg LH (2011) Clinical diagnosis and management of amyotrophic lateral sclerosis. Nat Rev Neurol 7(11):639–649

pubmed: 21989247 doi: 10.1038/nrneurol.2011.153

Hayakawa K, Chan SJ, Mandeville ET, Park JH, Bruzzese M, Montaner J, Arai K, Rosell A, Lo EH (2018) Protective effects of endothelial progenitor cell-derived extracellular mitochondria in brain endothelium. Stem Cells 36(9):1404–1410

pubmed: 29781122 doi: 10.1002/stem.2856

Hellström M, Gerhardt H, Kalén M, Li X, Eriksson U, Wolburg H, Betsholtz C (2001) Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis. J Cell Biol 153(3):543–554

pubmed: 11331305 pmcid: 2190573 doi: 10.1083/jcb.153.3.543

Herz J, Filiano AJ, Smith A, Yogev N, Kipnis JJI (2017) Myeloid cells in the central nervous system. Immunity 46(6):943–956

pubmed: 28636961 pmcid: 5657250 doi: 10.1016/j.immuni.2017.06.007

Hess DC, Borlongan CJ (2008) Stem cells and neurological diseases. Cell Prolif 41:94–114

pubmed: 18181951 doi: 10.1111/j.1365-2184.2008.00486.x

Hoang DM, Pham PT, Bach TQ, Ngo AT, Nguyen QT, Phan TT, Nguyen GH, Le PT, Hoang VT, Forsyth NR (2022) Stem cell-based therapy for human diseases. Sig Transduct Target Ther 7(1):272

doi: 10.1038/s41392-022-01134-4

Hong Y, Yu Q, Kong Z, Wang M, Zhang R, Li Y, Liu YJCD (2020) Exogenous endothelial progenitor cells reached the deficient region of acute cerebral ischemia rats to improve functional recovery via Bcl-2. Cardiovasc Diagn Ther 10(4):695

pubmed: 32968626 pmcid: 7487376 doi: 10.21037/cdt-20-329

Hristov M, Weber C (2008) Endothelial progenitor cells in vascular repair and remodeling. Pharmacol Res 58(2):148–151

pubmed: 18722530 doi: 10.1016/j.phrs.2008.07.008

Huang L, Wong S, Snyder EY, Hamblin MH, Lee J-PJ (2014) Human neural stem cells rapidly ameliorate symptomatic inflammation in early-stage ischemic-reperfusion cerebral injury. Stem Cell Res Ther 5(6):1–16

doi: 10.1186/scrt519

Jackson KA, Majka SM, Wang H, Pocius J, Hartley CJ, Majesky MW, Entman ML, Michael LH, Hirschi KK, Goodell MA (2001) Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells. J Clin Invest 107(11):1395–1402

pubmed: 11390421 pmcid: 209322 doi: 10.1172/JCI12150

Jeon O, Song SJ, Bhang SH, Choi C-Y, Kim MJ, Kim B-S (2007) Additive effect of endothelial progenitor cell mobilization and bone marrow mononuclear cell transplantation on angiogenesis in mouse ischemic limbs. J Biomed Sci 14(3):323–330

pubmed: 17265168 doi: 10.1007/s11373-007-9145-7

Kajitani T, Endo T, Iwabuchi N, Inoue T, Takahashi Y, Abe T, Niizuma K, Tominaga TJ (2021) Association of intravenous administration of human Muse cells with deficit amelioration in a rat model of spinal cord injury. J Neurosurg 34(4):648–655

Kalwitz G, Andreas K, Endres M, Neumann K, Notter M, Ringe J, Sittinger M, Kaps C (2010) Chemokine profile of human serum from whole blood: migratory effects of CXCL-10 and CXCL-11 on human mesenchymal stem cells. Connect Tissue Res 51(2):113–122

pubmed: 20001843 doi: 10.3109/03008200903111906

Keaney J, Campbell M (2015) The dynamic blood–brain barrier. FEBS J 282(21):4067–4079

pubmed: 26277326 doi: 10.1111/febs.13412

Kikuchi-Taura A, Okinaka Y, Takeuchi Y, Ogawa Y, Maeda M, Kataoka Y, Yasui T, Kimura T, Gul S, Claussen CJS (2020) Bone marrow mononuclear cells activate angiogenesis via gap junction-mediated cell–cell interaction. Stroke 51(4):1279–1289

pubmed: 32075549 doi: 10.1161/STROKEAHA.119.028072

Kim D-k, Nishida H, An SY, Shetty AK, Bartosh TJ, Prockop DJ (2016) Chromatographically isolated CD63+ CD81+ extracellular vesicles from mesenchymal stromal cells rescue cognitive impairments after TBI. Proc Natl Acad Sci USA 113(1):170–175

pubmed: 26699510 doi: 10.1073/pnas.1522297113

Kong Z, Hong Y, Zhu J, Cheng X (2018) Endothelial progenitor cells improve functional recovery in focal cerebral ischemia of rat by promoting angiogenesis via VEGF. J Clin Neurosci 55:116–121

pubmed: 30041898 doi: 10.1016/j.jocn.2018.07.011

Kuroda Y, Wakao S, Kitada M, Murakami T, Nojima M (2013) Isolation, culture and evaluation of multilineage-differentiating stress-enduring (Muse) cells. Nat Protoc 8(7):1391–1415

pubmed: 23787896 doi: 10.1038/nprot.2013.076

Lampron A, Pimentel-Coelho PM (2013) Migration of bone marrow-derived cells into the central nervous system in models of neurodegeneration. J Comp Neurol 521(17):3863–3876

pubmed: 23682015 doi: 10.1002/cne.23463

Li ZJ (2013) CD133: a stem cell biomarker and beyond. Exp Hematol Oncol 2(1):1–8

doi: 10.1186/2162-3619-2-17

Li T-S, Hamano K, Nishida M, Hayashi M, Ito H, Mikamo A, Matsuzaki MJ (2003) CD117+ stem cells play a key role in therapeutic angiogenesis induced by bone marrow cell implantation. Am J Physiol-Heart Circ Physiol 285(3):H931–H937

pubmed: 12915384 doi: 10.1152/ajpheart.01146.2002

Li H, Wang C, He T, Zhao T, Chen Y-Y, Shen Y-l, Zhang X, Wang L-l (2019) Mitochondrial transfer from bone marrow mesenchymal stem cells to motor neurons in spinal cord injury rats via gap junction. Theranostics 9(7):2017–2035

pubmed: 31037154 pmcid: 6485285 doi: 10.7150/thno.29400

Li C, Chen YH, Zhang K (2020) Neuroprotective properties and therapeutic potential of bone marrow-derived microglia in Alzheimer’s disease. Am J Alzheimers Dis Other Demen 35:1533317520927169. https://doi.org/10.1177/1533317520927169

doi: 10.1177/1533317520927169 pubmed: 32536247

Liao GP, Harting MT, Hetz RA, Walker PA, Shah SK, Corkins CJ, Hughes TG, Jimenez F, Kosmach SC (2015) Autologous bone marrow mononuclear cells reduce therapeutic intensity for severe traumatic brain injury in children. Pediatr Crit Care Med 16(3):245. https://doi.org/10.1097/PCC.0000000000000324

doi: 10.1097/PCC.0000000000000324 pubmed: 25581630 pmcid: 4351120

Liem NT, Anh TL, Thai TTH, Anh BV (2017) Bone marrow mononuclear cells transplantation in treatment of established bronchopulmonary dysplasia: a case report. Am J Case Rep 18:1090

pubmed: 29021519 pmcid: 5652889 doi: 10.12659/AJCR.905244

Liem NT, Chinh VD, Phuong DTM, Van Doan N, Forsyth NR, Heke M, Thi PAN, Nguyen X-H (2020a) Outcomes of bone marrow-derived mononuclear cell transplantation for patients in persistent vegetative state after drowning: report of five cases. Front Pediatr 8:564

pubmed: 33014944 pmcid: 7511512 doi: 10.3389/fped.2020.00564

Liem NT, Huyen TL, Huong LT, Doan NV, Anh BV, Anh NTP, Tung DT (2020b) Outcomes of bone marrow mononuclear cell transplantation for neurological sequelae due to intracranial hemorrhage incidence in the neonatal period: report of four cases. Front Pediatr 7:543

pubmed: 32039110 pmcid: 6993568 doi: 10.3389/fped.2019.00543

Liu X, Fu X, Dai G, Wang X, Zhang Z, Cheng H, Zheng P (2017) Comparative analysis of curative effect of bone marrow mesenchymal stem cell and bone marrow mononuclear cell transplantation for spastic cerebral palsy. J Transl Med 15(1):1–9

doi: 10.1186/s12967-017-1149-0

Liu K, Guo L, Zhou Z, Pan M, Yan C (2019) Mesenchymal stem cells transfer mitochondria into cerebral microvasculature and promote recovery from ischemic stroke. Microvasc Res 123:74–80

pubmed: 30611747 doi: 10.1016/j.mvr.2019.01.001

Majka M, Janowska-Wieczorek A, Ratajczak J, Ehrenman K, Pietrzkowski Z, Kowalska MA, Gewirtz AM, Emerson SG (1999) Numerous growth factors, cytokines, and chemokines are secreted by human CD34+ cells, myeloblasts, erythroblasts, and megakaryoblasts and regulate normal hematopoiesis in an autocrine/paracrine manner: Presented at the 41st Annual Meeting of the American Society of Hematology, New Orleans, LA, December 3–7, 1999, and published in abstract form in Blood. 1999; 94 (suppl 1): 465a. J Am Soc Hematol 97(10):3075–3085

Malliaras K, Marbán EJ (2011) Cardiac cell therapy: where we’ve been, where we are, and where we should be headed. Br Med Bull 98(1):161–185

pubmed: 21652595 pmcid: 3149211 doi: 10.1093/bmb/ldr018

Mancías-Guerra C, Marroquín-Escamilla AR, González-Llano O, Villarreal-Martínez L, Jaime-Pérez JC, García-Rodríguez F, Valdés-Burnes SL, Rodríguez-Romo LN, Barrera-Morales DC, Sánchez-Hernández JJJC (2014) Safety and tolerability of intrathecal delivery of autologous bone marrow nucleated cells in children with cerebral palsy: an open-label phase I trial. Cytotherapy 16(6):810–820

pubmed: 24642016 doi: 10.1016/j.jcyt.2014.01.008

Matejuk A, Vandenbark AA, Offner HJ (2021) Cross-talk of the CNS with immune cells and functions in health and disease. Front Neurol 12:672455

pubmed: 34135852 pmcid: 8200536 doi: 10.3389/fneur.2021.672455

Mathews D, Sugarman J, Bok H, Blass DM, Coyle J, Duggan P, Finkel J, Greely H, Hillis A, Hoke AJN (2008) Cell-based interventions for neurologic conditions: ethical challenges for early human trials. Neurology 71(4):288–293

pubmed: 18463365 doi: 10.1212/01.wnl.0000316436.13659.80

Matsubara T, Umemura Y, Ogura H, Matsuura H, Ebihara T, Matsumoto H, Yamakawa K, Shimizu K, Okada H, Shimazu TJ (2021) Bone marrow-derived mononuclear cell transplantation can reduce systemic inflammation and endothelial glycocalyx damage in sepsis. Shock 56(2):260–267

pubmed: 33337736 doi: 10.1097/SHK.0000000000001710

Matsumoto J, Stewart T, Sheng L, Li N, Bullock K, Song N, Shi M, Banks WA, Zhang JJ (2017) Transmission of α-synuclein-containing erythrocyte-derived extracellular vesicles across the blood-brain barrier via adsorptive mediated transcytosis: another mechanism for initiation and progression of Parkinson’s disease? Acta Neuropathol Commun 5(1):1–16

doi: 10.1186/s40478-017-0470-4

McGuckin CP, Jurga M, Miller A-M, Sarnowska A, Wiedner M, Boyle NT, Lynch MA, Jablonska A, Drela K, Lukomska BJ (2013) Ischemic brain injury: a consortium analysis of key factors involved in mesenchymal stem cell-mediated inflammatory reduction. Arch Biochem Biophys 534(1–2):88–97

pubmed: 23466243 doi: 10.1016/j.abb.2013.02.005

Mezey E, Chandross KJ, Harta G, Maki RA, McKercher SRJS (2000a) Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow. Science 290(5497):1779–1782

pubmed: 11099419 doi: 10.1126/science.290.5497.1779

Milczarek O, Jarocha D, Starowicz-Filip A, Kwiatkowski S, Badyra B, Majka MJ (2018) Multiple autologous bone marrow-derived CD271+ mesenchymal stem cell transplantation overcomes drug-resistant epilepsy in children. Stem Cells Transl Med 7(1):20–33

pubmed: 29224250 doi: 10.1002/sctm.17-0041

Miyan JA, Zendah M, Mashayekhi F, Owen-Lynch PJ (2006) Cerebrospinal fluid supports viability and proliferation of cortical cells in vitro, mirroring in vivo development. Cerebrospinal Fluid Res 3(1):1–7

doi: 10.1186/1743-8454-3-2

Moniche F, Gonzalez A, Gonzalez-Marcos JR, Carmona M, Pinero P, Espigado I, Garcia-Solis D, Cayuela A, Montaner J, Boada C, Rosell A, Jimenez MD, Mayol A, Gil-Peralta A (2012) Intra-arterial bone marrow mononuclear cells in ischemic stroke: a pilot clinical trial. Stroke 43(8):2242–2244. https://doi.org/10.1161/STROKEAHA.112.659409

doi: 10.1161/STROKEAHA.112.659409 pubmed: 22764211

Moniche F, Montaner J, Gonzalez-Marcos J-R, Carmona M, Piñero P, Espigado I, Cayuela A, Escudero I, De La Torre-Laviana F-J, Boada CJ (2014) Intra-arterial bone marrow mononuclear cell transplantation correlates with GM-CSF, PDGF-BB, and MMP-2 serum levels in stroke patients: results from a clinical trial. Cell Transpl 23:57–64

doi: 10.3727/096368914X684934

Montzka K, Lassonczyk N, Tschöke B, Neuss S, Führmann T, Franzen R, Smeets R, Brook GA (2009) Neural differentiation potential of human bone marrow-derived mesenchymal stromal cells: misleading marker gene expression. BMC Neurosci 10:1–12

doi: 10.1186/1471-2202-10-16

Mukherjee SB (2017) Autism spectrum disorders—diagnosis and management. Indian J Pediatr 84(4):307–314

pubmed: 28101829 doi: 10.1007/s12098-016-2272-2

Nguyen LT, Nguyen AT, Vu CD, Ngo DV, Bui AV (2017) Outcomes of autologous bone marrow mononuclear cells for cerebral palsy: an open label uncontrolled clinical trial. BMC Pediatr 17(1):1–6

doi: 10.1186/s12887-017-0859-z

Nguyen TL, Nguyen HP, Nguyen TKJH (2018) The effects of bone marrow mononuclear cell transplantation on the quality of life of children with cerebral palsy. Health Qual Life Outcomes 16(1):1–7

doi: 10.1186/s12955-018-0992-x

Nguyen LT, Hoang DM, Nguyen KT, Bui DM, Nguyen HT, Le HT, Hoang VT, Bui HT, Dam PT (2021) Type 2 diabetes mellitus duration and obesity alter the efficacy of autologously transplanted bone marrow-derived mesenchymal stem/stromal cells. Stem Cells Transl Med 10(9):1266–1278

pubmed: 34080789 pmcid: 8380443 doi: 10.1002/sctm.20-0506

Nguyen Thanh L, Nguyen HP, Ngo MD, Bui VA, Dam PT, Bui HTP, Ngo DV, Tran KT, Dang TTT, Duong BD (2021) Outcomes of bone marrow mononuclear cell transplantation combined with interventional education for autism spectrum disorder. Stem Cells Transl Med 10(1):14–26

pubmed: 32902182 doi: 10.1002/sctm.20-0102

Norat P, Soldozy S, Sokolowski JD, Gorick CM, Kumar JS, Chae Y, Yağmurlu K, Prada F, Walker M, Levitt MR (2020) Mitochondrial dysfunction in neurological disorders: exploring mitochondrial transplantation. Npj Regen Med 5(1):22

pubmed: 33298971 pmcid: 7683736 doi: 10.1038/s41536-020-00107-x

Ogawa Y, Saino O, Okinaka Y, Kikuchi-Taura A, Takeuchi Y, Taguchi AJ (2021) Bone marrow mononuclear cells transplantation and training increased transplantation of energy source transporters in chronic stroke. J Stroke Cerebrovasc Dis 30(8):105932

pubmed: 34148020 doi: 10.1016/j.jstrokecerebrovasdis.2021.105932

Otero-Ortega L, Laso-García F, Gómez-de Frutos MdC, Rodríguez-Frutos B, Pascual-Guerra J, Fuentes B, Díez-Tejedor E, Gutiérrez-Fernández MJ (2017) White matter repair after extracellular vesicles administration in an experimental animal model of subcortical stroke. Sci Rep 7(1):44433

pubmed: 28300134 pmcid: 5353554 doi: 10.1038/srep44433

Park C, Lee JY, Yoon Y-S (2011) Role of bone marrow-derived lymphatic endothelial progenitor cells for lymphatic neovascularization. Trends Cardiovasc Med 21(5):135–140

pubmed: 22732548 pmcid: 3384483 doi: 10.1016/j.tcm.2012.04.002

Patterson AM, Pelus LMJ (2017) G-CSF in stem cell mobilization: new insights, new questions. Ann Blood 2:10

pubmed: 30465039 pmcid: 6241316 doi: 10.21037/aob.2017.06.02

Pisati F, Bossolasco P, Meregalli M, Cova L, Belicchi M, Gavina M, Marchesi C, Calzarossa C, Soligo D, Lambertenghi-Deliliers GJ (2007) Induction of neurotrophin expression via human adult mesenchymal stem cells: implication for cell therapy in neurodegenerative diseases. Cell Transpl 16(1):41–55

doi: 10.3727/000000007783464443

Prabhakar S, Marwaha N, Lal V, Sharma RR, Rajan R, Khandelwal NJNI (2012) Autologous bone marrow-derived stem cells in amyotrophic lateral sclerosis: a pilot study. Neurology 60(5):465

Prasad K, Mohanty S, Bhatia R, Srivastava M, Garg A, Srivastava A, Goyal V, Tripathi M, Kumar A, Bal CJ (2012) Autologous intravenous bone marrow mononuclear cell therapy for patients with subacute ischaemic stroke: a pilot study. Indian J Med Res 136(2):221

pubmed: 22960888 pmcid: 3461733

Prasad K, Sharma A, Garg A, Mohanty S, Bhatnagar S, Johri S, Singh KK, Nair V, Sarkar RS, Gorthi SP, Hassan KM, Prabhakar S, Marwaha N, Khandelwal N, Misra UK, Kalita J, Nityanand S, Inve STSG (2014) Intravenous autologous bone marrow mononuclear stem cell therapy for ischemic stroke: a multicentric, randomized trial. Stroke 45(12):3618–3624. https://doi.org/10.1161/STROKEAHA.114.007028

doi: 10.1161/STROKEAHA.114.007028 pubmed: 25378424

Ramos-Zaldívar HM, Polakovicova I, Salas-Huenuleo E, Corvalán AH, Kogan MJ, Yefi CP, Andia MEJF (2022) Extracellular vesicles through the blood–brain barrier: a review. Fluids Barriers CNS 19(1):1–15

doi: 10.1186/s12987-022-00359-3

Reed SL, Escayg AJ (2021) Extracellular vesicles in the treatment of neurological disorders. Neurobiol Dis 157:105445

pubmed: 34271084 pmcid: 8817677 doi: 10.1016/j.nbd.2021.105445

Reed LJ, Attarian S, Olson TR, Singh S, Shestopalov A, Friedman EW (2018) Feasibility and safety of targeting the anterior superior iliac spine to perform a bone marrow procedure: a prospective, clinical study. J Clin Pathol 71(12):1116–1119

pubmed: 30352912 doi: 10.1136/jclinpath-2018-205309

Reza-Zaldivar EE, Hernández-Sapiéns MA, Gutiérrez-Mercado YK, Sandoval-Ávila S, Gomez-Pinedo U, Márquez-Aguirre AL, Vázquez-Méndez E, Padilla-Camberos E, Canales-Aguirre AAJ (2019) Mesenchymal stem cell-derived exosomes promote neurogenesis and cognitive function recovery in a mouse model of Alzheimer’s disease. Neural Regener Res 14(9):1626

doi: 10.4103/1673-5374.255978

Rosado-de-Castro PH, Schmidt Fda R, Battistella V, Lopes de Souza SA, Gutfilen B, Goldenberg RC, Kasai-Brunswick TH, Vairo L, Silva RM, Wajnberg E, Americano A (2013a) Biodistribution of bone marrow mononuclear cells after intra-arterial or intravenous transplantation in subacute stroke patients. Regen Med 8(2):145–155. https://doi.org/10.2217/rme.13.2

doi: 10.2217/rme.13.2 pubmed: 23477395

Rosado-de-Castro PH, Schmidt FR, Battistella V, Lopes de Souza SA, Gutfilen B, Goldenberg RC, Kasai-Brunswick TH, Vairo L, Silva RM, Wajnberg EJ (2013b) Biodistribution of bone marrow mononuclear cells after intra-arterial or intravenous transplantation in subacute stroke patients. Regener Med 8(2):145–155

doi: 10.2217/rme.13.2

Rosenbaum P, Paneth N, Leviton A, Goldstein M, Bax M, Damiano D, Dan B, Jacobsson B (2007) A report: the definition and classification of cerebral palsy April 2006. Dev Med Child Neurol Suppl 109:8–14

pubmed: 17370477

Rosenfeld JV, Maas AI, Bragge P, Morganti-Kossmann MC, Manley GT, Gruen RL (2012) Early management of severe traumatic brain injury. Lancet 380(9847):1088–1098. https://doi.org/10.1016/S0140-6736(12)60864-2

doi: 10.1016/S0140-6736(12)60864-2 pubmed: 22998718

Ruan J, Miao X, Schlüter D, Lin L, Wang XJMT (2021) Extracellular vesicles in neuroinflammation: pathogenesis, diagnosis, and therapy. Mol Therapy 29(6):1946–1957

doi: 10.1016/j.ymthe.2021.04.020

Ruiz-López FJ, Guardiola J, Izura V, Gómez-Espuch J, Iniesta F, Blanquer M, López-San Román J, Saez V, De Mingo P (2016) Breathing pattern in a phase I clinical trial of intraspinal injection of autologous bone marrow mononuclear cells in patients with amyotrophic lateral sclerosis. Respir Physiol Neurobiol 221:54–58

pubmed: 26593639 doi: 10.1016/j.resp.2015.11.007

Saha A, Patel S, Xu L, Scotland P, Schwartzman J, Filiano AJ, Kurtzberg J, Balber AE (2019) Human umbilical cord blood monocytes, but not adult blood monocytes, rescue brain cells from hypoxic-ischemic injury: mechanistic and therapeutic implications. PLoS ONE 14(9):e0218906

pubmed: 31483780 pmcid: 6726370 doi: 10.1371/journal.pone.0218906

Sanchez-Ramos J, Song S, Cardozo-Pelaez F, Hazzi C, Stedeford T, Willing A, Freeman T, Saporta S, Janssen W (2000) Adult bone marrow stromal cells differentiate into neural cells in vitro. Exp Neurol 164(2):247–256

pubmed: 10915564 doi: 10.1006/exnr.2000.7389

Sane H, Sharma A, Gokulchandran N, Kalburgi S, Paranjape A (2016) Neurorestoration in amyotrophic lateral sclerosis-a case report. Indian J Stem Cell Therapy 4:29–37

Savitz SI, Misra V, Kasam M, Juneja H, Cox CS Jr, Alderman S, Aisiku I, Kar S, Gee A, Grotta JC (2011) Intravenous autologous bone marrow mononuclear cells for ischemic stroke. Ann Neurol 70(1):59–69

pubmed: 21786299 doi: 10.1002/ana.22458

Sharma S, Yang B, Strong R, Xi X, Brenneman M, Grotta JC, Aronowski J, Savitz SI (2010) Bone marrow mononuclear cells protect neurons and modulate microglia in cell culture models of ischemic stroke. J Neurosci Res 88(13):2869–2876

pubmed: 20629187 pmcid: 3401573

Sharma A, Kulkarni P, Sane H, Gokulchandran N, Badhe P, Lohia M, Mishra PJ (2012) Positron emission tomography-computed tomography scan captures the effects of cellular therapy in a case of cerebral palsy. J Clin Case Rep 2(13):195

doi: 10.4172/2165-7920.1000195

Sharma A, Badhe P, Gokulchandran N, Kulkarni P, Mishra P, Shetty A, Sane HJJ (2013a) An improved case of autism as revealed by PET CT scan in patient transplanted with autologous bone marrow derived mononuclear cells. J Stem Cell Res Ther 3(139):2

Sharma A, Gokulchandran N, Sane H, Kulkarni P, Thomas N, Paranjape A, Badhe PJA (2013b) Intrathecal autologous bone marrow mononuclear cell transplantation in a case of adult autism. Autism 3(2):113

Sharma A, Gokulchandran N, Sane H, Nagrajan A, Paranjape A, Kulkarni P, Shetty A, Mishra P, Kali M, Biju HJ (2013c) Autologous bone marrow mononuclear cell therapy for autism: an open label proof of concept study. Stem Cells Int 2013:1–13

doi: 10.1155/2013/623875

Sharma A, Gokulchandran N, Shetty A, Sane H, Kulkarni P, Badhe PJ (2013d) Autologous bone marrow mononuclear cells may be explored as a novel potential therapeutic option for autism. Stem Cells Int 3(282):2

Sharma A, Sane H, Paranjape A, Gokulchandran N, Kulkarni P, Nagrajan A, Badhe PJ (2013e) Positron emission tomography—computer tomography scan used as a monitoring tool following cellular therapy in cerebral palsy and mental retardation—a case report. Case Rep Neurol Med 2013:1–6

Sharma A, Sane H, Gokulchandran N, Khopkar D, Paranjape A, Sundaram J, Gandhi S, Badhe P (2014) Autologous bone marrow mononuclear cells intrathecal transplantation in chronic stroke. Stroke Res Treat 2014:234095. https://doi.org/10.1155/2014/234095

doi: 10.1155/2014/234095 pubmed: 25126443 pmcid: 4121152

Sharma A, Gokulchandran N, Sane H, Patil A, Shetty A, Biju H, Kulkarni P, Badhe PJ (2015a) Amelioration of autism by autologous bone marrow mononuclear cells and neurorehabilitation: a case report. Stem Cells Int 3(10):304–309

Sharma A, Sane H, Gokulchandran N, Kulkarni P, Gandhi S, Sundaram J, Paranjape A, Shetty A, Bhagwanani K, Biju HJ (2015b) A clinical study of autologous bone marrow mononuclear cells for cerebral palsy patients: a new frontier. Stem Cells Int 2015:1–11

doi: 10.1155/2015/905874

Sharma A, Sane H, Kulkarni P, D’sa M, Gokulchandran N, Badhe PJCJ (2015c) Improved quality of life in a case of cerebral palsy after bone marrow mononuclear cell transplantation. Cell J 17(2):389

pubmed: 26199918 pmcid: 4503853

Sharma AK, Sane HM, Paranjape AA, Gokulchandran N, Nagrajan A, Dsa M, Badhe PBJ (2015d) The effect of autologous bone marrow mononuclear cell transplantation on the survival duration in amyotrophic lateral sclerosis-a retrospective controlled study. Am J Stem Cells 4(1):50

pubmed: 25973331 pmcid: 4396155

Sharma A, Gokulchandran N, Sane H, Kulkarni P, Pai SJ (2017) A case of autism showing clinical improvements after cellular therapy along with PET CT evidence. J Stem Cell Res Ther 2(4):00070

Sharma A, Gokulchandran N, Sane H, Kulkarni P, Nivins S, Maheshwari M, Badhe PJIB, Journal B (2018) Therapeutic effects of cellular therapy in a case of adult autism spectrum of disorder. Int Biol Biomed J 4(2):98–103

Sharma A, Sane H, Pradhan R, Paranjape A, Gokulchandran N, Kaur J, Das R, Badhe P (2019) Case report neuroregenerative rehabilitation therapy with long-term lithium in a male amyotrophic lateral sclerosis patient: a case report. Int J Med Sci Clin Invent 6:4337–4344

doi: 10.18535/ijmsci/v6i2.11

Sharma A, Sane H, Gokulchandran N, Kulkarni P, Jose A, Nair V, Das R, Lakhanpal V, Badhe P (2020a) Intrathecal transplantation of autologous bone marrow mononuclear cells in patients with sub-acute and chronic spinal cord injury: an open-label study. Int J Health Sci (qassim) 14(2):24–32

pubmed: 32206057

Sharma A, Sane H, Gokulchandran N, Kulkarni P, Jose A, Nair V, Das R, Lakhanpal V (2020b) Intrathecal transplantation of autologous bone marrow mononuclear cells in patients with sub-acute and chronic spinal cord injury: an open-label study. Cell Regen 14(2):24

Sharma A, Sane H, Paranjape A, Pradhan R, Das R, Biju H, Gokulchandran N, Badhe PJC (2020c) Multiple doses of cell therapy and neurorehabilitation in amyotrophic lateral sclerosis: a case report. Clin Pract 10(3):82–85

doi: 10.4081/cp.2020.1242

Sharma AK, Gokulchandran N, Kulkarni PP, Sane HM, Sharma R, Jose A, Badhe PB (2020d) Cell transplantation as a novel therapeutic strategy for autism spectrum disorders: a clinical study. Am J Stem Cells 9(5):89

pubmed: 33489466 pmcid: 7811933

Sharma AK, Sane HM, Kulkarni PP, Gokulchandran N, Biju H, Badhe PB (2020e) Autologous bone marrow mononuclear cell transplantation in patients with chronic traumatic brain injury-a clinical study. Cell Regen 9(1):3. https://doi.org/10.1186/s13619-020-00043-7

doi: 10.1186/s13619-020-00043-7 pubmed: 32588151 pmcid: 7306831

Sharma AK, Sane HM, Kulkarni PP, Gokulchandran N, Biju H, Badhe PB (2020f) Autologous bone marrow mononuclear cell transplantation in patients with chronic traumatic brain injury-a clinical study. Cell Regen 9(1):1–11

doi: 10.1186/s13619-020-00043-7

Sohni A, Verfaillie CM (2013) Mesenchymal stem cells migration homing and tracking. Stem Cells Int 2013:1–8

doi: 10.1155/2013/130763

Somoza R, Conget P, Rubio FJ (2008) Neuropotency of human mesenchymal stem cell cultures: clonal studies reveal the contribution of cell plasticity and cell contamination. Biol Blood Marrow 14(5):546–555

doi: 10.1016/j.bbmt.2008.02.017

Song S, Song S, Zhang H, Cuevas J, Sanchez-Ramos JJ (2007) Comparison of neuron-like cells derived from bone marrow stem cells to those differentiated from adult brain neural stem cells. Stem Cells Dev 16(5):747–756

pubmed: 17999596 doi: 10.1089/scd.2007.0027

Stonesifer C, Corey S, Ghanekar S, Diamandis Z, Acosta SA, Borlongan CV (2017) Stem cell therapy for abrogating stroke-induced neuroinflammation and relevant secondary cell death mechanisms. Progr Neurobiol 158:94–131

doi: 10.1016/j.pneurobio.2017.07.004

Stratman AN, Malotte KM, Mahan RD, Davis MJ, Davis GEJB (2009) Pericyte recruitment during vasculogenic tube assembly stimulates endothelial basement membrane matrix formation. J Am Soc Hematol 114(24):5091–5101

Suárez-Monteagudo C, Hernández-Ramírez P, Álvarez-González L, García-Maeso I, de la Cuétara-Bernal K, Castillo-Díaz L, Bringas-Vega ML, Martínez-Aching G, Morales-Chacón LM (2009) Autologous bone marrow stem cell neurotransplantation in stroke patients. An open study. Neuroscience 27(3):151–161

Suarez-Monteagudo C, Hernandez-Ramirez P, Alvarez-Gonzalez L, Garcia-Maeso I, de la Cuetara-Bernal K, Castillo-Diaz L, Bringas-Vega ML, Martinez-Aching G, Morales-Chacon LM, Baez-Martin MM, Sanchez-Catasus C, Carballo-Barreda M, Rodriguez-Rojas R, Gomez-Fernandez L, Alberti-Amador E, Macias-Abraham C, Balea ED, Rosales LC, Del Valle PL, Ferrer BB, Gonzalez RM, Bergado JA (2009) Autologous bone marrow stem cell neurotransplantation in stroke patients. An open study. Restor Neurol Neurosci 27(3):151–161. https://doi.org/10.3233/RNN-2009-0483

doi: 10.3233/RNN-2009-0483 pubmed: 19531871

Suda S (2017) Bone marrow-derived mononuclear cells. In: Houkin K, Abe K, Kuroda S (eds) Cell therapy against cerebral stroke. Springer, Tokyo, pp 3–14

doi: 10.1007/978-4-431-56059-3_1

Suda S, Katsura KI, Saito M, Kamiya N, Katayama Y (2014) Valproic acid enhances the effect of bone marrow-derived mononuclear cells in a rat ischemic stroke model. Brain Res 1565:74–81

pubmed: 24746498 doi: 10.1016/j.brainres.2014.04.011

Sudulaguntla A, Nanjwade B, Chandy VJ (2017) Stem cells: cultivation and routes of administration. Current Trends Biomed Eng Biosci 2:555579

doi: 10.19080/CTBEB.2017.02.555579

Sugihara S, Yamamoto Y, Matsuura T, Narazaki G, Yamasaki A, Igawa G, Matsubara K, Miake J, Igawa O, Shigemasa CJ (2007) Age-related BM-MNC dysfunction hampers neovascularization. Mech Ageing Dev 128(9):511–516

pubmed: 17688912 doi: 10.1016/j.mad.2007.06.009

Suzuki Y, Ishikawa N, Omae K, Hirai T, Ohnishi K, Nakano N, Nishida H, Nakatani T, Fukushima M, Ide C (2014) Bone marrow-derived mononuclear cell transplantation in spinal cord injury patients by lumbar puncture. Restor Neurol Neurosci 32(4):473–482. https://doi.org/10.3233/RNN-130363

doi: 10.3233/RNN-130363 pubmed: 24670611

Taguchi A, Wen Z, Myojin K, Yoshihara T, Nakagomi T, Nakayama D, Tanaka H, Soma T, Stern DM, Naritomi HJ (2007) Granulocyte colony-stimulating factor has a negative effect on stroke outcome in a murine model. Eur J Neurosci 26(1):126–133

pubmed: 17614944 doi: 10.1111/j.1460-9568.2007.05640.x

Taguchi A, Sakai C, Soma T, Kasahara Y, Stern DM, Kajimoto K, Ihara M, Daimon T, Yamahara K, Doi K, Kohara N, Nishimura H, Matsuyama T, Naritomi H, Sakai N, Nagatsuka K (2015a) Intravenous autologous bone marrow mononuclear cell transplantation for stroke: phase1/2a clinical trial in a homogeneous group of stroke patients. Stem Cells Dev 24(19):2207–2218. https://doi.org/10.1089/scd.2015.0160

doi: 10.1089/scd.2015.0160 pubmed: 26176265 pmcid: 4582686

Taguchi A, Sakai C, Soma T, Kasahara Y, Stern DM, Kajimoto K, Ihara M, Daimon T, Yamahara K, Doi KJ (2015b) Intravenous autologous bone marrow mononuclear cell transplantation for stroke: phase1/2a clinical trial in a homogeneous group of stroke patients. Stem Cells Dev 24(19):2207–2218

pubmed: 26176265 pmcid: 4582686 doi: 10.1089/scd.2015.0160

Takamura H, Terashima T, Mori K, Katagi M, Okano J, Suzuki Y, Imai S, Kojima H (2020) Bone-marrow-derived mononuclear cells relieve neuropathic pain after spinal nerve injury in mice. Mol Therapy 17:657–665

Talbott EO, Malek AM, Lacomis D (2016) The epidemiology of amyotrophic lateral sclerosis. Handb Clin Neurol 138:225–238

pubmed: 27637961 doi: 10.1016/B978-0-12-802973-2.00013-6

Tamburin S, Smania N, Saltuari L, Hoemberg V, Sandrini GJ (2019) New advances in neurorehabilitation. Front Neurol. https://doi.org/10.3389/fneur.2019.01090

doi: 10.3389/fneur.2019.01090 pubmed: 31681155 pmcid: 6812690

Tamura K, Maeta N (2020) Efficacy of autologous bone marrow mononuclear cell transplantation in dogs with chronic spinal cord injury. Open Vet J 10(2):206–215. https://doi.org/10.4314/ovj.v10i2.10

doi: 10.4314/ovj.v10i2.10 pubmed: 32821665 pmcid: 7419067

Tan YL, Eng SP, Hafez P, AbdulKarim N, Law JX, Ng MH (2022) Mesenchymal stromal cell mitochondrial transfer as a cell rescue strategy in regenerative medicine: a review of evidence in preclinical models. Stem Cells Transl Med 11(8):814–827

pubmed: 35851922 pmcid: 9397650 doi: 10.1093/stcltm/szac044

Terada N, Hamazaki T, Oka M, Hoki M, Mastalerz DM, Nakano Y, Meyer EM, Morel L, Petersen BE, Scott EW (2002) Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion. Nature 416(6880):542–545

pubmed: 11932747 doi: 10.1038/nature730

Terry T, Chen Z, Dixon RA, Vanderslice P, Zoldhelyi P, Willerson JT, Liu QJ (2011) CD34+/M-cadherin+ bone marrow progenitor cells promote arteriogenesis in ischemic hindlimbs of ApoE−/− mice. PLoS ONE 6(6):e20673

pubmed: 21677770 pmcid: 3108984 doi: 10.1371/journal.pone.0020673

Thanh LN, Trung KN, Duy CV, Van DN, Hoang PN, Phuong ANT, Ngo MD, Thi TN, Viet AB (2019) Improvement in gross motor function and muscle tone in children with cerebral palsy related to neonatal icterus: an open-label, uncontrolled clinical trial. BMC Pediatr 19(1):1–8

doi: 10.1186/s12887-019-1669-2

Uccelli A, Wolff T, Valente P, Di Maggio N, Pellegrino M, Gürke L, Banfi A, Gianni-Barrera RJ (2019) Vascular endothelial growth factor biology for regenerative angiogenesis. Swiss Med Wkly. https://doi.org/10.4414/smw.2019.20011

doi: 10.4414/smw.2019.20011 pubmed: 30685867

Uchida H, Niizuma K, Kushida Y, Wakao S, Tominaga T, Borlongan CV, Dezawa M (2017) Human Muse cells reconstruct neuronal circuitry in subacute lacunar stroke model. Stroke 48(2):428–435

pubmed: 27999136 doi: 10.1161/STROKEAHA.116.014950

Urbich C, Heeschen C, Aicher A, Dernbach E, Zeiher AM, Dimmeler S (2003) Relevance of monocytic features for neovascularization capacity of circulating endothelial progenitor cells. Circulation 108(20):2511–2516

pubmed: 14581410 doi: 10.1161/01.CIR.0000096483.29777.50

Vahidy FS, Rahbar MH, Zhu H, Rowan PJ, Bambhroliya AB, Savitz SIJ (2016) Systematic review and meta-analysis of bone marrow–derived mononuclear cells in animal models of ischemic stroke. Stroke 47(6):1632–1639

pubmed: 27165959 pmcid: 4879076 doi: 10.1161/STROKEAHA.116.012701

Vahidy FS, Haque ME, Rahbar MH, Zhu H, Rowan P, Aisiku IP, Lee DA, Juneja HS, Alderman S, Barreto AD, Suarez JI, Bambhroliya A, Hasan KM, Kassam MR, Aronowski J, Gee A, Cox CS Jr, Grotta JC, Savitz SI (2019) Intravenous bone marrow mononuclear cells for acute ischemic stroke: safety, feasibility, and effect size from a phase I clinical trial. Stem Cells 37(11):1481–1491. https://doi.org/10.1002/stem.3080

doi: 10.1002/stem.3080 pubmed: 31529663

Vasconcelos-dos-Santos A, Rosado-de-Castro PH, de Souza SAL, da Costa SJ, Ramos AB, de Freitas GR, da Fonseca LMB, Gutfilen B, Mendez-Otero RJ (2012) Intravenous and intra-arterial administration of bone marrow mononuclear cells after focal cerebral ischemia: is there a difference in biodistribution and efficacy? Stem Cell Res 9(1):1–8

pubmed: 22445868 doi: 10.1016/j.scr.2012.02.002

Vassilopoulos G, Wang PR, Russell DW (2003) Transplanted bone marrow regenerates liver by cell fusion. Nature 422(6934):901–904

pubmed: 12665833 doi: 10.1038/nature01539

Vendrame M, Cassady J, Newcomb J, Butler T, Pennypacker KR, Zigova T, Davis Sanberg C, Sanberg PR, Willing AEJS (2004) Infusion of human umbilical cord blood cells in a rat model of stroke dose-dependently rescues behavioral deficits and reduces infarct volume. Stroke 35(10):2390–2395

pubmed: 15322304 doi: 10.1161/01.STR.0000141681.06735.9b

Vendrame M, Gemma C, Pennypacker KR, Bickford PC, Sanberg CD, Sanberg PR, Willing AE (2006) Cord blood rescues stroke-induced changes in splenocyte phenotype and function. Exp Neurol 199(1):191–200

pubmed: 16713598 doi: 10.1016/j.expneurol.2006.03.017

Wagner D-C, Bojko M, Peters M, Lorenz M, Voigt C, Kaminski A, Hasenclever D, Scholz M, Kranz A, Weise GJE (2012) Impact of age on the efficacy of bone marrow mononuclear cell transplantation in experimental stroke. Exp Transl Stroke Med 4(1):1–8

doi: 10.1186/2040-7378-4-17

Wang X, Willenbring H, Akkari Y, Torimaru Y, Foster M, Al-Dhalimy M, Lagasse E, Finegold M, Olson S, Grompe M (2003) Cell fusion is the principal source of bone-marrow-derived hepatocytes. Nature 422(6934):897–901

pubmed: 12665832 doi: 10.1038/nature01531

Wang J, Liu X, Lu H, Jiang C, Cui X, Yu L, Fu X, Li Q, Wang JJB (2015) CXCR4+ CD45− BMMNC subpopulation is superior to unfractionated BMMNCs for protection after ischemic stroke in mice. Brain Behav Immunity 45:98–108

doi: 10.1016/j.bbi.2014.12.015

Wang B, Lian Y-J, Su W-J, Peng W, Dong X, Liu L-L, Gong H, Zhang T, Jiang C-L, Wang Y-XJB (2018) HMGB1 mediates depressive behavior induced by chronic stress through activating the kynurenine pathway. Brain Behav Immunity 72:51–60

doi: 10.1016/j.bbi.2017.11.017

Wang TY, Park C, Zhang H, Rahimpour S, Murphy KR, Goodwin CR, Karikari IO, Than KD, Shaffrey CI, Foster N, Abd-El-Barr MM (2021) Management of acute traumatic spinal cord injury: a review of the literature. Front Surg 8:698736

pubmed: 34966774 pmcid: 8710452 doi: 10.3389/fsurg.2021.698736

Wei W, Li L, Deng L, Wang Z-J, Dong J-J, Lyu X-Y, Jia T, Wang L, Wang H-X, Mao HJ (2020) Autologous bone marrow mononuclear cell transplantation therapy improved symptoms in patients with refractory diabetic sensorimotor polyneuropathy via the mechanisms of paracrine and immunomodulation: a controlled study. Cell Transpl 1:1. https://doi.org/10.1177/0963689720949258

doi: 10.1177/0963689720949258

WHO (2020) International perspectives on spinal cord injury

Wiklander OP, Nordin JZ, O’Loughlin A, Gustafsson Y, Corso G, Mäger I, Vader P, Lee Y, Sork H, Seow YJ (2015) Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting. J Extracell Ves 4(1):26316

doi: 10.3402/jev.v4.26316

Wilkins A, Kemp K, Ginty M, Hares K, Mallam E, Scolding NJ (2009) Human bone marrow-derived mesenchymal stem cells secrete brain-derived neurotrophic factor which promotes neuronal survival in vitro. Stem Cell Res 3(1):63–70

pubmed: 19411199 doi: 10.1016/j.scr.2009.02.006

Xiao Z, Tang F, Tang J, Yang H, Zhao Y, Chen B, Han S, Wang N, Li X, Cheng SJSCLS (2016) One-year clinical study of NeuroRegen scaffold implantation following scar resection in complete chronic spinal cord injury patients. Sci China Life Sci 59(7):647–655. https://doi.org/10.1007/s11427-016-5080-z

doi: 10.1007/s11427-016-5080-z pubmed: 27333785

Xin H, Li Y, Cui Y, Yang JJ, Zhang ZG, Chopp MJ (2013) Systemic administration of exosomes released from mesenchymal stromal cells promote functional recovery and neurovascular plasticity after stroke in rats. J Cereb Blood Flow Metab 33(11):1711–1715

pubmed: 23963371 pmcid: 3824189 doi: 10.1038/jcbfm.2013.152

Xu K, Lee JY, Kaneko Y, Tuazon JP, Vale F, van Loveren H, Borlongan CV (2019) Human stem cells transplanted into the rat stroke brain migrate to the spleen via lymphatic and inflammation pathways. Haematologica 104(5):1062

pubmed: 30514806 pmcid: 6518907 doi: 10.3324/haematol.2018.206581

Yamashita T, Kushida Y, Wakao S, Tadokoro K, Nomura E, Omote Y, Takemoto M, Hishikawa N, Ohta Y (2020) Therapeutic benefit of Muse cells in a mouse model of amyotrophic lateral sclerosis. Sci Rep 10(1):1–11

doi: 10.1038/s41598-020-74216-4

Yang B, Strong R, Sharma S, Brenneman M, Mallikarjunarao K, Xi X, Grotta JC, Aronowski J, Savitz SI (2011) Therapeutic time window and dose response of autologous bone marrow mononuclear cells for ischemic stroke. J Neurosci Res 89(6):833–839

pubmed: 21412816 pmcid: 3412881 doi: 10.1002/jnr.22614

Yang B, Migliati E, Parsha K, Schaar K, Xi X, Aronowski J, Savitz SI (2013) Intra-arterial delivery is not superior to intravenous delivery of autologous bone marrow mononuclear cells in acute ischemic stroke. Stroke 44(12):3463–3472

pubmed: 24114454 pmcid: 4209211 doi: 10.1161/STROKEAHA.111.000821

Yang B, Parsha K, Schaar K, Xi X, Aronowski J, Savitz SI (2016) Various cell populations within the mononuclear fraction of bone marrow contribute to the beneficial effects of autologous bone marrow cell therapy in a rodent stroke model. Transl Stroke Res 7(4):322–330

pubmed: 26997513 pmcid: 4929026 doi: 10.1007/s12975-016-0462-x

Yang B, Hamilton JA, Valenzuela KS, Bogaerts A, Xi X, Aronowski J, Mays RW, Savitz SI (2017) Multipotent adult progenitor cells enhance recovery after stroke by modulating the immune response from the spleen. Stem Cells 35(5):1290–1302

pubmed: 28263009 doi: 10.1002/stem.2600

Yoshihara T, Ohta M, Itokazu Y, Matsumoto N, Dezawa M, Suzuki Y, Taguchi A, Watanabe Y, Adachi Y, Ikehara S, Sugimoto H, Ide C (2007) Neuroprotective effect of bone marrow-derived mononuclear cells promoting functional recovery from spinal cord injury. J Neurotrauma 24(6):1026–1036. https://doi.org/10.1089/neu.2007.132R

doi: 10.1089/neu.2007.132R pubmed: 17600518

Yuan D, Zhao Y, Banks WA, Bullock KM, Haney M, Batrakova E, Kabanov AV (2017) Macrophage exosomes as natural nanocarriers for protein delivery to inflamed brain. Biomaterials 142:1–12

pubmed: 28715655 pmcid: 5603188 doi: 10.1016/j.biomaterials.2017.07.011

Yuan Y, Sun J, You T, Shen W, Xu W, Dong Q, Cui M (2022) Extracellular vesicle-based therapeutics in neurological disorders. Pharmaceutics 14(12):2652

pubmed: 36559145 pmcid: 9783774 doi: 10.3390/pharmaceutics14122652

Zadeh G, Guha A (2003) Angiogenesis in nervous system disorders. Neurosurgery 53(6):1362–1376

pubmed: 14633302 doi: 10.1227/01.NEU.0000093425.98136.31

Zahid MF, Murad MH, Litzow MR, Hogan WJ, Patnaik MS, Khorana A, Spyropoulos AC, Hashmi SKJ (2016) Venous thromboembolism following hematopoietic stem cell transplantation—a systematic review and meta-analysis. Ann Hematol 95(9):1457–1464

pubmed: 27103008 doi: 10.1007/s00277-016-2673-3

Zhang B, Yin Y, Lai RC, Tan SS, Choo ABH, Lim SK (2014) Mesenchymal stem cells secrete immunologically active exosomes. Stem Cells Dev 23(11):1233–1244

pubmed: 24367916 doi: 10.1089/scd.2013.0479

Zhang Y, Chopp M, Meng Y, Katakowski M, Xin H, Mahmood A, Xiong YJ (2015) Effect of exosomes derived from multipluripotent mesenchymal stromal cells on functional recovery and neurovascular plasticity in rats after traumatic brain injury. J Neurosurg 122(4):856–867

pubmed: 25594326 pmcid: 4382456 doi: 10.3171/2014.11.JNS14770

Zhang H, Ding L, Shen T, Peng DJ (2019) HMGB1 involved in stress-induced depression and its neuroinflammatory priming role: a systematic review. General Psychiatry 32(4):e100084

pubmed: 31552388 pmcid: 6738663 doi: 10.1136/gpsych-2019-100084

Zhao E, Xu H, Wang L, Kryczek I, Wu K, Hu Y, Wang G, Zou WJ (2012) Bone marrow and the control of immunity. Cell Mol Immunol 9(1):11–19

pubmed: 22020068 doi: 10.1038/cmi.2011.47

Zhao Y, Gan Y, Xu G, Yin G, Liu DJ (2020) MSCs-derived exosomes attenuate acute brain injury and inhibit microglial inflammation by reversing CysLT2R-ERK1/2 mediated microglia M1 polarization. Neurochem Res 45(5):1180–1190

pubmed: 32112178 doi: 10.1007/s11064-020-02998-0

Zhuang Z, Liu M, Luo J, Zhang X, Dai Z, Zhang B, Chen H, Xue J, He M, Xu H, Liu A (2022) Exosomes derived from bone marrow mesenchymal stem cells attenuate neurological damage in traumatic brain injury by alleviating glutamate-mediated excitotoxicity. Exp Neurol 357:114182

pubmed: 35901975 doi: 10.1016/j.expneurol.2022.114182

Zhuo Y, Li S-H, Chen M-S, Wu J, Kinkaid HYM, Fazel S, Weisel RD, Li R-K (2010) Aging impairs the angiogenic response to ischemic injury and the activity of implanted cells: combined consequences for cell therapy in older recipients. J Thorac Cardiovasc Surg 139(5):1286–1294

pubmed: 19931095 doi: 10.1016/j.jtcvs.2009.08.052

Bone Marrow-Derived Mononuclear Cells in the Treatment of Neurological Diseases: Knowns and Unknowns.

Journal

Informations de publication

Résumé

Identifiants

Types de publication

Langues

Sous-ensembles de citation

Pagination

Informations de copyright

Références

Auteurs

Quyen Thi Nguyen (QT)

Liem Nguyen Thanh (LN)

Van T Hoang (VT)

Trang T K Phan (TTK)

Michael Heke (M)

Duc M Hoang (DM)

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Smoking Cessation and Incident Cardiovascular Disease.

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Classifications MeSH