Apolipoprotein E in lipid metabolism and neurodegenerative disease.
Alzheimer's disease
apolipoprotein E
lipid metabolism
neurodegenerative disease
Journal
Trends in endocrinology and metabolism: TEM
ISSN: 1879-3061
Titre abrégé: Trends Endocrinol Metab
Pays: United States
ID NLM: 9001516
Informations de publication
Date de publication:
08 2023
08 2023
Historique:
received:
15
03
2023
revised:
05
05
2023
accepted:
09
05
2023
pmc-release:
01
08
2024
medline:
14
7
2023
pubmed:
26
6
2023
entrez:
25
6
2023
Statut:
ppublish
Résumé
Dysregulation of lipid metabolism has emerged as a central component of many neurodegenerative diseases. Variants of the lipid transport protein, apolipoprotein E (APOE), modulate risk and resilience in several neurodegenerative diseases including late-onset Alzheimer's disease (LOAD). Allelic variants of the gene, APOE, alter the lipid metabolism of cells and tissues and have been broadly associated with several other cellular and systemic phenotypes. Targeting APOE-associated metabolic pathways may offer opportunities to alter disease-related phenotypes and consequently, attenuate disease risk and impart resilience to multiple neurodegenerative diseases. We review the molecular, cellular, and tissue-level alterations to lipid metabolism that arise from different APOE isoforms. These changes in lipid metabolism could help to elucidate disease mechanisms and tune neurodegenerative disease risk and resilience.
Identifiants
pubmed: 37357100
pii: S1043-2760(23)00092-9
doi: 10.1016/j.tem.2023.05.002
pmc: PMC10365028
mid: NIHMS1911683
pii:
doi:
Substances chimiques
Apolipoproteins E
0
Types de publication
Journal Article
Review
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
430-445Subventions
Organisme : Intramural NIH HHS
ID : Z99 DK999999
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA DK075158
Pays : United States
Informations de copyright
Published by Elsevier Ltd.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no conflicts of interest.
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