KIF16B Mediates Anterograde Transport and Modulates Lysosomal Degradation of the HIV-1 Envelope Glycoprotein.
HIV-1
KIF16B
envelope glycoprotein
kinesin
recycling
trafficking
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
27 07 2023
27 07 2023
Historique:
pmc-release:
26
12
2023
medline:
28
7
2023
pubmed:
26
6
2023
entrez:
26
6
2023
Statut:
ppublish
Résumé
The human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) is incorporated into virions at the site of particle assembly on the plasma membrane (PM). The route taken by Env to reach the site of assembly and particle incorporation remains incompletely understood. Following initial delivery to the PM through the secretory pathway, Env is rapidly endocytosed, suggesting that recycling is required for particle incorporation. Endosomes marked by the small GTPase Rab14 have been previously shown to play a role in Env trafficking. Here, we examined the role of KIF16B, the molecular motor protein that directs outward movement of Rab14-dependent cargo, in Env trafficking. Env colocalized extensively with KIF16B
Identifiants
pubmed: 37358446
doi: 10.1128/jvi.00255-23
pmc: PMC10373548
doi:
Substances chimiques
Glycoproteins
0
KIF16B protein, human
0
Kinesins
EC 3.6.4.4
Rab14 protein, human
EC 3.6.1.-
rab GTP-Binding Proteins
EC 3.6.5.2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0025523Subventions
Organisme : NIAID NIH HHS
ID : R01 AI150486
Pays : United States
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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