Characterization of Two Novel Inhibitors of the Mycobacterium tuberculosis Cytochrome

Humans Mycobacterium tuberculosis / genetics Antitubercular Agents / pharmacology Tuberculosis, Multidrug-Resistant Electron Transport Cytochromes / pharmacology Electron Transport Complex III / genetics
ATP Mycobacterium tuberculosis QcrB antibiotic cytochrome bc1 drug screening

Journal

Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061

Informations de publication

Date de publication:
18 07 2023
Historique:
pmc-release: 26 12 2023
medline: 17 7 2023
pubmed: 26 6 2023
entrez: 26 6 2023
Statut: ppublish

Résumé

Drug-resistant tuberculosis is a global health care threat calling for novel effective treatment options. Here, we report on two novel cytochrome

Identifiants

DOI: 10.1128/aac.00251-23 PMID: 37358461 PMC: PMC10353358
pubmed: 37358461
doi: 10.1128/aac.00251-23
pmc: PMC10353358
doi:

Substances chimiques

Antitubercular Agents 0
Cytochromes 0
Electron Transport Complex III EC 7.1.1.8

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0025123

Références

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pubmed: 23776831

Auteurs

Raphael Gries (R)

Department I of Internal Medicine, Medical Faculty and University Hospital Cologne, University of Cologne, Cologne, Germany.
Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany.
ORCID: 0000-0003-2997-3693

Michael Dal Molin (M)

Department I of Internal Medicine, Medical Faculty and University Hospital Cologne, University of Cologne, Cologne, Germany.
Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
ORCID: 0000-0002-1587-6692

Jason Chhen (J)

Department I of Internal Medicine, Medical Faculty and University Hospital Cologne, University of Cologne, Cologne, Germany.
Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.

Edeltraud van Gumpel (E)

Department I of Internal Medicine, Medical Faculty and University Hospital Cologne, University of Cologne, Cologne, Germany.
Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.

Viola Dreyer (V)

Molecular and Experimental Mycobacteriology, Research Center Borstel, Borstel, Germany.
German Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Borstel, Germany.
ORCID: 0000-0003-2997-3693

Stefan Niemann (S)

Molecular and Experimental Mycobacteriology, Research Center Borstel, Borstel, Germany.
German Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Borstel, Germany.
ORCID: 0000-0002-6604-0684

Jan Rybniker (J)

Department I of Internal Medicine, Medical Faculty and University Hospital Cologne, University of Cologne, Cologne, Germany.
Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany.
ORCID: 0000-0001-8351-2690

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Characterization of Two Novel Inhibitors of...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets asporogènes à Gram positif › Bâtonnets asporogènes réguliers à Gram positif › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis › Characterization of Two Novel Inhibitors of...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Antituberculeux › Characterization of Two Novel Inhibitors of...
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Infections bactériennes à Gram positif › Infections à Actinomycetales › Infections à Mycobacterium › Tuberculose › Tuberculose multirésistante › Characterization of Two Novel Inhibitors of...
questionsmedicales.fr › Métabolisme › Voies et réseaux métaboliques › Transport d'électrons › Characterization of Two Novel Inhibitors of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Hémoprotéines › Cytochromes › Characterization of Two Novel Inhibitors of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Métalloprotéines › Protéines de liaison au fer › Protéines à fer non hème › Ferrosulfoprotéines › Complexe III de la chaîne respiratoire › Characterization of Two Novel Inhibitors of...