Hypoxia in the Pathophysiology of Inflammatory Bowel Disease.
Journal
Comprehensive Physiology
ISSN: 2040-4603
Titre abrégé: Compr Physiol
Pays: United States
ID NLM: 101574442
Informations de publication
Date de publication:
26 06 2023
26 06 2023
Historique:
medline:
28
6
2023
pubmed:
26
6
2023
entrez:
26
6
2023
Statut:
epublish
Résumé
Inflammatory bowel disease (IBD) is an idiopathic disease of disordered chronic inflammation in the intestines that affects many people across the world. While the disease is still being better characterized, greater progress has been made in understanding the many components that intersect in the disease. Among these components are the many pieces that compose the intestinal epithelial barrier, the various cytokines and immune cells, and the population of microbes that reside in the intestinal lumen. Since their discovery, the hypoxia-inducible factors (HIFs) have been found to play an expansive role in physiology as well as diseases such as inflammation due to their role in oxygen sensing-related gene transcription, and metabolic control. Making use of existing and developing paradigms in the immuno-gastroenterology of IBD, we summarized that hypoxic signaling plays as another component in the status and progression of IBD, which may include possible functions at the origins of inflammatory dysregulation. © 2023 American Physiological Society. Compr Physiol 13:4767-4783, 2023.
Identifiants
pubmed: 37358514
doi: 10.1002/cphy.c220002
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
4767-4783Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM130422
Pays : United States
Informations de copyright
Copyright © 2023 American Physiological Society. All rights reserved.
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