Distinct and shared neuropsychiatric phenotypes in FTLD-tauopathies.
behavioral variant frontotemporal dementia
corticobasal degeneration
frontotemporal lobar degeneration
neuropsychiatric symptoms
pick disease
primary progressive aphasia
progressive supranuclear palsy
Journal
Frontiers in aging neuroscience
ISSN: 1663-4365
Titre abrégé: Front Aging Neurosci
Pays: Switzerland
ID NLM: 101525824
Informations de publication
Date de publication:
2023
2023
Historique:
received:
13
02
2023
accepted:
09
05
2023
medline:
26
6
2023
pubmed:
26
6
2023
entrez:
26
6
2023
Statut:
epublish
Résumé
Frontotemporal lobar degeneration (FTLD) with tau pathology (FTLD-tau) commonly causes dementia syndromes that include primary progressive aphasia (PPA) and behavioral variant frontotemporal dementia (bvFTD). Cognitive decline in PPA and bvFTD is often accompanied by debilitating neuropsychiatric symptoms. In 44 participants with PPA or bvFTD due to autopsy-confirmed FTLD-tau, we characterized neuropsychiatric symptoms at early and late disease stages and determined whether the presence of certain symptoms predicted a specific underlying FTLD-tauopathy. Participants completed annual research visits at the Northwestern University Alzheimer's Disease Research Center. All participants had an initial Global Clinical Dementia Rating (CDR) Scale score ≤ 2, and neuropsychiatric symptoms were evaluated
Identifiants
pubmed: 37358954
doi: 10.3389/fnagi.2023.1164581
pmc: PMC10289868
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1164581Subventions
Organisme : NIA NIH HHS
ID : F31 AG076318
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG072977
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG062566
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS085770
Pays : United States
Informations de copyright
Copyright © 2023 Keszycki, Kawles, Minogue, Zouridakis, Macomber, Gill, Vu, Zhang, Coventry, Rogalski, Weintraub, Mesulam, Geula and Gefen.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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