Association between the development of bronchopulmonary dysplasia and platelet transfusion: a protocol for a systematic review and meta-analysis.
NICU
bronchopulmonary dysplasia
chronic lung disease of prematurity
platelet transfusion
preterm infant
Journal
Frontiers in pediatrics
ISSN: 2296-2360
Titre abrégé: Front Pediatr
Pays: Switzerland
ID NLM: 101615492
Informations de publication
Date de publication:
2023
2023
Historique:
received:
07
11
2022
accepted:
10
04
2023
medline:
26
6
2023
pubmed:
26
6
2023
entrez:
26
6
2023
Statut:
epublish
Résumé
There is a lack of consensus on the management of thrombocytopenia in preterm infants, and the threshold for prophylactic platelet transfusion varies widely among clinicians and institutions. Reports in animal models suggested that platelets may play a relevant role in lung alveolarization and regeneration. Bronchopulmonary dysplasia (BPD) is a severe respiratory condition with a multifactorial origin that affects infants born at the early stages of lung development. Recent randomized controlled trials on the platelets count threshold for prophylactic transfusions in preterm infants with thrombocytopenia suggest that a higher exposition to platelet transfusion may increase the risk of BPD. Here, we report a protocol for a systematic review, which aims to assist evidence-based clinical practice and clarify if the administration of platelet products may be associated with the incidence of BPD and/or death in preterm infants. MEDLINE, Embase, Cochrane databases, and sources of gray literature for conference abstracts and trial registrations will be searched with no time or language restrictions. Case-control studies, cohort studies, and nonrandomized or randomized trials that evaluated the risk for BPD and/or death in preterm infants exposed to platelet transfusion will be included. Data from studies that are sufficiently similar will be pooled as appropriate. Data extraction forms will be developed This systematic review will investigate the association of BPD/death with platelet components administration in preterm infants, and, consequently, it will provide reliable indications for the evidence-based management of premature patients with thrombocytopenia.
Sections du résumé
Background
There is a lack of consensus on the management of thrombocytopenia in preterm infants, and the threshold for prophylactic platelet transfusion varies widely among clinicians and institutions. Reports in animal models suggested that platelets may play a relevant role in lung alveolarization and regeneration. Bronchopulmonary dysplasia (BPD) is a severe respiratory condition with a multifactorial origin that affects infants born at the early stages of lung development. Recent randomized controlled trials on the platelets count threshold for prophylactic transfusions in preterm infants with thrombocytopenia suggest that a higher exposition to platelet transfusion may increase the risk of BPD. Here, we report a protocol for a systematic review, which aims to assist evidence-based clinical practice and clarify if the administration of platelet products may be associated with the incidence of BPD and/or death in preterm infants.
Methods
MEDLINE, Embase, Cochrane databases, and sources of gray literature for conference abstracts and trial registrations will be searched with no time or language restrictions. Case-control studies, cohort studies, and nonrandomized or randomized trials that evaluated the risk for BPD and/or death in preterm infants exposed to platelet transfusion will be included. Data from studies that are sufficiently similar will be pooled as appropriate. Data extraction forms will be developed
Discussion
This systematic review will investigate the association of BPD/death with platelet components administration in preterm infants, and, consequently, it will provide reliable indications for the evidence-based management of premature patients with thrombocytopenia.
Identifiants
pubmed: 37360369
doi: 10.3389/fped.2023.1049014
pmc: PMC10289060
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1049014Informations de copyright
© 2023 Chioma, Ghirardello, Włodarczyk, Ulan-Drozdowska, Spagarino, Szumska, Krasuska, Seliga-Siwecka, Philip, Al Assaf and Pierro.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
BMJ Open. 2020 Oct 16;10(10):e039132
pubmed: 33067290
JAMA Pediatr. 2016 Jul 1;170(7):687-94
pubmed: 27213618
J Pediatr. 1978 Apr;92(4):529-34
pubmed: 305471
BMC Med Res Methodol. 2014 Dec 19;14:135
pubmed: 25524443
Arch Ophthalmol. 2005 Jul;123(7):991-9
pubmed: 16009843
Stat Med. 2016 Feb 20;35(4):485-95
pubmed: 26303773
Sci Rep. 2014 Mar 11;4:4340
pubmed: 24614152
Lancet. 2017 Oct 14;390(10104):1770-1780
pubmed: 28434651
Pediatr Clin North Am. 2009 Jun;56(3):579-600, Table of Contents
pubmed: 19501693
N Engl J Med. 2019 Jan 17;380(3):242-251
pubmed: 30387697
Front Med (Lausanne). 2015 Aug 07;2:49
pubmed: 26301222
J Thromb Haemost. 2003 Sep;1(9):1897-905
pubmed: 12941029
BMJ. 2008 Apr 26;336(7650):924-6
pubmed: 18436948
Transfusion. 2011 Dec;51(12):2634-41
pubmed: 21658049
Pediatr Clin North Am. 1986 Feb;33(1):179-201
pubmed: 3081865
Circulation. 2006 Oct 24;114(17):1873-82
pubmed: 17060397
Pediatrics. 1999 Dec;104(6):1345-50
pubmed: 10585987
Blood. 2018 Sep 13;132(11):1167-1179
pubmed: 29853539
Best Pract Res Clin Anaesthesiol. 2007 Jun;21(2):183-93
pubmed: 17650771
Nature. 2017 Apr 6;544(7648):105-109
pubmed: 28329764
Am J Respir Crit Care Med. 2001 Jun;163(7):1723-9
pubmed: 11401896
Arch Neurol. 2008 Oct;65(10):1291-5
pubmed: 18852342
Pediatrics. 2009 Jan;123(1):278-85
pubmed: 19117893
J Pediatr. 2018 Jun;197:300-308
pubmed: 29551318
Res Pract Thromb Haemost. 2020 Apr 19;4(4):481-490
pubmed: 32548549
J Perinatol. 2008 Jun;28(6):420-6
pubmed: 18337740
Res Synth Methods. 2010 Apr;1(2):97-111
pubmed: 26061376
BMC Med Res Methodol. 2015 Apr 14;15:35
pubmed: 25880989
Ann Surg. 1978 Jan;187(1):1-7
pubmed: 413500
BMJ. 2008 May 3;336(7651):995-8
pubmed: 18456631
J Clin Epidemiol. 2011 Apr;64(4):383-94
pubmed: 21195583