What the BTBR/J mouse has taught us about diabetes and diabetic complications.
Animal physiology
Human metabolism
Model organism
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
21 Jul 2023
21 Jul 2023
Historique:
medline:
26
6
2023
pubmed:
26
6
2023
entrez:
26
6
2023
Statut:
epublish
Résumé
Human and mouse genetics have delivered numerous diabetogenic loci, but it is mainly through the use of animal models that the pathophysiological basis for their contribution to diabetes has been investigated. More than 20 years ago, we serendipidously identified a mouse strain that could serve as a model of obesity-prone type 2 diabetes, the BTBR (Black and Tan Brachyury) mouse (BTBR T+ Itpr3tf/J, 2018) carrying the
Identifiants
pubmed: 37360692
doi: 10.1016/j.isci.2023.107036
pii: S2589-0042(23)01113-6
pmc: PMC10285641
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
107036Subventions
Organisme : BLRD VA
ID : I01 BX005804
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK110324
Pays : United States
Organisme : BLRD VA
ID : I01 BX003700
Pays : United States
Organisme : NIDDK NIH HHS
ID : R00 DK095975
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK102598
Pays : United States
Organisme : BLRD VA
ID : I01 BX004715
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK120684
Pays : United States
Organisme : BLRD VA
ID : I01 BX001880
Pays : United States
Organisme : NIDDK NIH HHS
ID : K99 DK095975
Pays : United States
Informations de copyright
© 2023 The Author(s).
Déclaration de conflit d'intérêts
The authors declare no competing interests
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