Maternal and paternal tuberculosis is associated with increased asthma and respiratory symptoms in their offspring: a study from Northern Europe.
asthma
epigenetic
generational study
offspring asthma
tuberculosis
Journal
Frontiers in allergy
ISSN: 2673-6101
Titre abrégé: Front Allergy
Pays: Switzerland
ID NLM: 9918227355906676
Informations de publication
Date de publication:
2023
2023
Historique:
received:
24
03
2023
accepted:
24
05
2023
medline:
26
6
2023
pubmed:
26
6
2023
entrez:
26
6
2023
Statut:
epublish
Résumé
Given the profound impact of tuberculosis (TB) on immunity and given murine studies suggesting that infections may influence immunity across generations, we hypothesize that parental TB might impact health and disease in future offspring. This study investigated the impact of maternal and paternal TB on offspring asthma and respiratory symptoms. We included data from the third follow-up of the Respiratory Health in Northern Europe study (RHINE). Information on own asthma status, asthma-like symptoms and other respiratory symptoms, as well as information about parental TB and asthma, were collected using standardized questionnaires. The associations between parental TB and RHINE participants' asthma and respiratory symptoms were analyzed using multiple logistic regression, with adjustment for parental education, smoking habits and asthma. Of 8,323 study participants, 227 (2.7%) reported only paternal TB, 282 (3.4%) only maternal TB, and 33 (0.4%) reported that both parents had TB. We found a higher risk of asthma (aOR: 1.29, 95% CI: 1.05-1.57) in offspring with a history of parental TB as compared to offspring without parental TB., Parental TB was significantly associated with allergic asthma in offspring (aOR: 1.58, 95% CI: 1.29-2.05), while no significant association between parental TB and asthma without allergy (aOR: 1.00, 95% CI: 0.76-1.32) in offspring was observed. Results from this study indicate that parental TB might be a risk factor for offspring's asthma and respiratory symptoms. We raise the hypothesis that the immunological impact of infections might be transmitted to influence offspring phenotype in humans.
Sections du résumé
Background
UNASSIGNED
Given the profound impact of tuberculosis (TB) on immunity and given murine studies suggesting that infections may influence immunity across generations, we hypothesize that parental TB might impact health and disease in future offspring.
Objective
UNASSIGNED
This study investigated the impact of maternal and paternal TB on offspring asthma and respiratory symptoms.
Methods
UNASSIGNED
We included data from the third follow-up of the Respiratory Health in Northern Europe study (RHINE). Information on own asthma status, asthma-like symptoms and other respiratory symptoms, as well as information about parental TB and asthma, were collected using standardized questionnaires. The associations between parental TB and RHINE participants' asthma and respiratory symptoms were analyzed using multiple logistic regression, with adjustment for parental education, smoking habits and asthma.
Results
UNASSIGNED
Of 8,323 study participants, 227 (2.7%) reported only paternal TB, 282 (3.4%) only maternal TB, and 33 (0.4%) reported that both parents had TB. We found a higher risk of asthma (aOR: 1.29, 95% CI: 1.05-1.57) in offspring with a history of parental TB as compared to offspring without parental TB., Parental TB was significantly associated with allergic asthma in offspring (aOR: 1.58, 95% CI: 1.29-2.05), while no significant association between parental TB and asthma without allergy (aOR: 1.00, 95% CI: 0.76-1.32) in offspring was observed.
Conclusion
UNASSIGNED
Results from this study indicate that parental TB might be a risk factor for offspring's asthma and respiratory symptoms. We raise the hypothesis that the immunological impact of infections might be transmitted to influence offspring phenotype in humans.
Identifiants
pubmed: 37361110
doi: 10.3389/falgy.2023.1193141
pmc: PMC10286510
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1193141Informations de copyright
© 2023 Gyawali, López-Cervantes, Johannessen, Gislason, Holm, Janson, Jögi, Modig, Schlünssen, Mustafa and Svanes.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
J Clin Tuberc Other Mycobact Dis. 2022 Mar 17;27:100311
pubmed: 35313724
J Allergy Clin Immunol. 2018 Sep;142(3):765-772
pubmed: 30040975
Cell Rep. 2020 Apr 28;31(4):107573
pubmed: 32348768
J Allergy Clin Immunol. 2000 Nov;106(5 Suppl):S201-5
pubmed: 11080732
Int J Epidemiol. 2018 Aug 1;47(4):1106-1117
pubmed: 29534228
Eur Respir J. 2005 Jul;26(1):28-35
pubmed: 15994386
Am J Respir Crit Care Med. 1998 Jul;158(1):176-81
pubmed: 9655726
Allergy Asthma Clin Immunol. 2005 Jun 15;1(2):81-7
pubmed: 20529228
Lancet. 2008 Sep 20;372(9643):1049-57
pubmed: 18805333
Clin Epigenetics. 2018 Jun 28;10:89
pubmed: 29988283
Parasite Immunol. 2020 Sep;42(9):e12721
pubmed: 32277499
Int J Tuberc Lung Dis. 2022 Jun 1;26(6):544-549
pubmed: 35650692
Trends Genet. 2022 Jul;38(7):662-675
pubmed: 35410793
Semin Cell Dev Biol. 2022 Jul;127:121-132
pubmed: 34426067
COPD. 2017 Apr;14(2):143-149
pubmed: 27880044
Cell Metab. 2017 Mar 7;25(3):559-571
pubmed: 28273478
Chest. 2007 Jun;131(6):1817-24
pubmed: 17400690
Allergy. 2007 Feb;62(2):142-8
pubmed: 17298422
PLoS One. 2010 Apr 12;5(4):e10134
pubmed: 20405032
Int J Infect Dis. 2020 Mar;92S:S41-S45
pubmed: 32114203
Thorax. 2016 Dec;71(12):1071-1072
pubmed: 27601431
EClinicalMedicine. 2021 Feb 26;33:100752
pubmed: 33718847
ERJ Open Res. 2023 May 22;9(3):
pubmed: 37228275
J Allergy Clin Immunol. 2017 Feb;139(2):415-421
pubmed: 28183434
Eur Respir J. 2015 Sep;46(3):622-39
pubmed: 26206872