HIF and MYC signaling in adrenal neoplasms of the neural crest: implications for pediatrics.
MYC
catecholamines
hypoxia
neural crest
neuroblastoma
paraganglioma
pheochromocytoma
sympathoadrenal cell lineage
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2023
2023
Historique:
received:
18
08
2022
accepted:
09
05
2023
medline:
28
6
2023
pubmed:
26
6
2023
entrez:
26
6
2023
Statut:
epublish
Résumé
Pediatric neural crest-derived adrenal neoplasms include neuroblastoma and pheochromocytoma. Both entities are associated with a high degree of clinical heterogeneity, varying from spontaneous regression to malignant disease with poor outcome. Increased expression and stabilization of HIF2α appears to contribute to a more aggressive and undifferentiated phenotype in both adrenal neoplasms, whereas
Identifiants
pubmed: 37361539
doi: 10.3389/fendo.2023.1022192
pmc: PMC10286580
doi:
Substances chimiques
Proto-Oncogene Proteins c-myc
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1022192Informations de copyright
Copyright © 2023 Bechmann, Westermann and Eisenhofer.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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