Liver and Renal Impairments in COVID-19 Patients of Madinah City of Saudi Arabia: A Cross-Sectional Study (2020).
alanine aminotransferase
albumin
aspartate aminotransferase
chronic obstructive pulmonary disorder
covid-19
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
May 2023
May 2023
Historique:
accepted:
22
05
2023
medline:
26
6
2023
pubmed:
26
6
2023
entrez:
26
6
2023
Statut:
epublish
Résumé
Purpose Most of the research on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (coronavirus disease 2019 [COVID-19]) has mainly focused on the lungs as a key organ involved in the disease, while very little data is available regarding the involvement of other organs including the liver and kidneys, which are also reported to be severely affected by the disease. The objective of this study was to analyze the effect of COVID-19 disease on liver and kidney functions and to determine their association with the severity and mortality of the disease. This was a retrospective cross-sectional analysis of medical records. Methods A total of 100 confirmed COVID-19 adult patients from Madinah, Saudi Arabia hospitalized between April 28 and June 30, 2020, were included and categorized into asymptomatic, mild to moderate, and severely ill patients. We analyzed the clinical status of liver and renal functioning in all three groups. Results Most patients (51%) were diagnosed with mild to moderate disease, 27% of patients were severely ill and 22% of patients were asymptomatic. The liver and renal functional analysis showed that the severity of the COVID-19 patients was significantly associated with renal impairments exhibiting higher levels of creatinine and urea (P<0.05) with high levels of liver enzymes as indicators for liver damage. Conclusion We concluded from the present study that severely ill COVID-19 patients were more prone to have abnormal liver and renal functions. The present findings, however, demand further study of the association between liver and kidney impairments with COVID-19 infection for better clinical management.
Identifiants
pubmed: 37362525
doi: 10.7759/cureus.39409
pmc: PMC10287181
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e39409Informations de copyright
Copyright © 2023, Mohammedsaeed et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Lancet Gastroenterol Hepatol. 2020 May;5(5):428-430
pubmed: 32145190
Lancet Respir Med. 2020 Apr;8(4):420-422
pubmed: 32085846
J Am Soc Nephrol. 2006 Nov;17(11):3067-75
pubmed: 17021266
JAMA. 2020 Mar 17;323(11):1061-1069
pubmed: 32031570
N Engl J Med. 2020 Apr 30;382(18):1708-1720
pubmed: 32109013
J Am Soc Nephrol. 2020 Jul;31(7):1380-1383
pubmed: 32366514
Hepatology. 2004 Feb;39(2):302-10
pubmed: 14767982
J Pathol. 2004 Jun;203(2):631-7
pubmed: 15141377
J Hepatol. 2020 Sep;73(3):566-574
pubmed: 32298767
J Clin Transl Hepatol. 2020 Mar 28;8(1):18-24
pubmed: 32274342
Lancet. 2020 Feb 15;395(10223):507-513
pubmed: 32007143
Kidney Int. 2005 Feb;67(2):698-705
pubmed: 15673319
N Engl J Med. 2020 Mar 26;382(13):1199-1207
pubmed: 31995857
J Hepatol. 2020 Aug;73(2):451-453
pubmed: 32278005
Front Med (Lausanne). 2021 Jan 13;7:563893
pubmed: 33521006
Chin Med J (Engl). 2020 May 5;133(9):1087-1095
pubmed: 32358325