Probing the diabetes and colorectal cancer relationship using gene - environment interaction analyses.

Humans Gene-Environment Interaction Genetic Predisposition to Disease Risk Factors Diabetes Mellitus / genetics Colorectal Neoplasms / genetics Polymorphism, Single Nucleotide Genome-Wide Association Study / methods Microfilament Proteins / genetics

Journal

British journal of cancer
ISSN: 1532-1827
Titre abrégé: Br J Cancer
Pays: England
ID NLM: 0370635

Informations de publication

Date de publication:
08 2023
Historique:
received: 09 11 2022
accepted: 06 06 2023
revised: 10 05 2023
medline: 7 8 2023
pubmed: 27 6 2023
entrez: 26 6 2023
Statut: ppublish

Résumé

Diabetes is an established risk factor for colorectal cancer. However, the mechanisms underlying this relationship still require investigation and it is not known if the association is modified by genetic variants. To address these questions, we undertook a genome-wide gene-environment interaction analysis. We used data from 3 genetic consortia (CCFR, CORECT, GECCO; 31,318 colorectal cancer cases/41,499 controls) and undertook genome-wide gene-environment interaction analyses with colorectal cancer risk, including interaction tests of genetics(G)xdiabetes (1-degree of freedom; d.f.) and joint testing of Gxdiabetes, G-colorectal cancer association (2-d.f. joint test) and G-diabetes correlation (3-d.f. joint test). Based on the joint tests, we found that the association of diabetes with colorectal cancer risk is modified by loci on chromosomes 8q24.11 (rs3802177, SLC30A8 - OR These results suggest that variation in genes related to insulin signaling (SLC30A8) and immune function (LRCH1) may modify the association of diabetes with colorectal cancer risk and provide novel insights into the biology underlying the diabetes and colorectal cancer relationship.

Sections du résumé

BACKGROUND
Diabetes is an established risk factor for colorectal cancer. However, the mechanisms underlying this relationship still require investigation and it is not known if the association is modified by genetic variants. To address these questions, we undertook a genome-wide gene-environment interaction analysis.
METHODS
We used data from 3 genetic consortia (CCFR, CORECT, GECCO; 31,318 colorectal cancer cases/41,499 controls) and undertook genome-wide gene-environment interaction analyses with colorectal cancer risk, including interaction tests of genetics(G)xdiabetes (1-degree of freedom; d.f.) and joint testing of Gxdiabetes, G-colorectal cancer association (2-d.f. joint test) and G-diabetes correlation (3-d.f. joint test).
RESULTS
Based on the joint tests, we found that the association of diabetes with colorectal cancer risk is modified by loci on chromosomes 8q24.11 (rs3802177, SLC30A8 - OR
DISCUSSION
These results suggest that variation in genes related to insulin signaling (SLC30A8) and immune function (LRCH1) may modify the association of diabetes with colorectal cancer risk and provide novel insights into the biology underlying the diabetes and colorectal cancer relationship.

Identifiants

DOI: 10.1038/s41416-023-02312-z PMID: 37365285 PMC: PMC10403521
pubmed: 37365285
doi: 10.1038/s41416-023-02312-z
pii: 10.1038/s41416-023-02312-z
pmc: PMC10403521
doi:

Substances chimiques

LRCH1 protein, human 0
Microfilament Proteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural Research Support, U.S. Gov't, P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

511-520

Subventions

Organisme : NCI NIH HHS
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Informations de copyright

© 2023. The Author(s).

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Auteurs

Niki Dimou (N)

Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France. DimouN@iarc.who.int.
ORCID: 0000-0003-1678-9328

Andre E Kim (AE)

Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Orlagh Flanagan (O)

Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France.

Neil Murphy (N)

Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France.
ORCID: 0000-0003-3347-8249

Virginia Diez-Obrero (V)

Unit of Biomarkers and Susceptibility, Oncology Data Analytics Program, Catalan Institute of Oncology, Barcelona, 08908, Spain.
Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute, Barcelona, 08908, Spain.
Consortium for Biomedical Research in Epidemiology and Public Health, Barcelona, 08908, Spain.
Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, 08908, Spain.

Anna Shcherbina (A)

Department of Genetics, Stanford University, Stanford, CA, USA.
Department of Computer Science, Stanford University, Stanford, CA, USA.

Elom K Aglago (EK)

School of Public Health, Imperial College London, London, United Kingdom.
ORCID: 0000-0002-0442-3284

Emmanouil Bouras (E)

Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece.
ORCID: 0000-0003-1489-5506

Peter T Campbell (PT)

Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.

Graham Casey (G)

Department of Public Health Sciences, Center for Public Health Genomics, Charlottesville, VA, USA.

Steven Gallinger (S)

Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.

Stephen B Gruber (SB)

Center for Precision Medicine, Department of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, CA, USA.

Mark A Jenkins (MA)

Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.

Yi Lin (Y)

Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.

Victor Moreno (V)

Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, 08908, Spain.
Oncology Data Analytics Program, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.
CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
ONCOBEL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.
ORCID: 0000-0002-2818-5487

Edward Ruiz-Narvaez (E)

Department of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA.
ORCID: 0000-0002-0339-5824

Mariana C Stern (MC)

Department of Population and Public Health Sciences & USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Yu Tian (Y)

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
School of Public Health, Capital Medical University, Beijing, China.

Kostas K Tsilidis (KK)

School of Public Health, Imperial College London, London, United Kingdom.
Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece.

Volker Arndt (V)

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
ORCID: 0000-0001-9320-8684

Elizabeth L Barry (EL)

Department of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.

James W Baurley (JW)

Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia.
BioRealm LLC, Walnut, CA, USA.

Sonja I Berndt (SI)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Stéphane Bézieau (S)

Nantes Université, CHU Nantes, Service de Génétique médicale, F-44000, Nantes, France.

Stephanie A Bien (SA)

Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.

D Timothy Bishop (DT)

Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK.
ORCID: 0000-0002-8752-8785

Hermann Brenner (H)

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany.
German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
ORCID: 0000-0002-6129-1572

Arif Budiarto (A)

Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia.
Computer Science Department, School of Computer Science, Bina Nusantara University, Jakarta, Indonesia.

Robert Carreras-Torres (R)

Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, 8908, Barcelona, Spain.

Tjeng Wawan Cenggoro (TW)

Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia.

Andrew T Chan (AT)

Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.
Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.
ORCID: 0000-0001-7284-6767

Jenny Chang-Claude (J)

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
University Medical Centre Hamburg-Eppendorf, University Cancer Centre Hamburg (UCCH), Hamburg, Germany.

Stephen J Chanock (SJ)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Xuechen Chen (X)

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany.
ORCID: 0000-0003-2476-7110

David V Conti (DV)

Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Christopher H Dampier (CH)

Department of Public Health Sciences, Center for Public Health Genomics, Charlottesville, VA, USA.
Department of General Surgery, University of Virginia School of Medicine, Charlottesville, VA, USA.

Matthew Devall (M)

Department of Family Medicine, University of Virginia, Charlottesville, VA, USA.

David A Drew (DA)

Clinical & Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Jane C Figueiredo (JC)

Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Graham G Giles (GG)

Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia.
Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia.

Andrea Gsur (A)

Center for Cancer Research, Medical University of Vienna, Vienna, Austria.

Tabitha A Harrison (TA)

Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.

Akihisa Hidaka (A)

Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.

Michael Hoffmeister (M)

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
ORCID: 0000-0002-8307-3197

Jeroen R Huyghe (JR)

Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
ORCID: 0000-0001-6027-9806

Kristina Jordahl (K)

Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.

Eric Kawaguchi (E)

Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Temitope O Keku (TO)

Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, NC, USA.

Susanna C Larsson (SC)

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
ORCID: 0000-0003-0118-0341

Loic Le Marchand (L)

University of Hawaii Cancer Center, Honolulu, HI, USA.

Juan Pablo Lewinger (JP)

Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Li Li (L)

Department of Family Medicine, University of Virginia, Charlottesville, VA, USA.

Bharuno Mahesworo (B)

Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia.

John Morrison (J)

Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Polly A Newcomb (PA)

Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
School of Public Health, University of Washington, Seattle, WA, USA.
ORCID: 0000-0001-8786-0043

Christina C Newton (CC)

Department of Population Science, American Cancer Society, Atlanta, GA, USA.

Mireia Obon-Santacana (M)

Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO-IDIBELL), Avda Gran Via Barcelona 199-203, 08908L'Hospitalet de Llobregat, Barcelona, Spain.

Jennifer Ose (J)

Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
Department of Population Health Sciences, University of Utah, Salt Lake City, UH, USA.

Rish K Pai (RK)

Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, Scottsdale, AZ, USA.

Julie R Palmer (JR)

Slone Epidemiology Center at Boston University, Boston, MA, USA.
ORCID: 0000-0002-6534-335X

Nikos Papadimitriou (N)

Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France.

Bens Pardamean (B)

Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia.

Anita R Peoples (AR)

Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
Department of Population Health Sciences, University of Utah, Salt Lake City, UH, USA.

Paul D P Pharoah (PDP)

Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
ORCID: 0000-0001-8494-732X

Elizabeth A Platz (EA)

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

John D Potter (JD)

Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA.
Research Centre for Hauora and Health, Massey University, Wellington, New Zealand.
ORCID: 0000-0001-5439-1500

Gad Rennert (G)

Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel.
Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Clalit National Cancer Control Center, Haifa, Israel.

Peter C Scacheri (PC)

Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA.

Robert E Schoen (RE)

Department of Medicine and Epidemiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Yu-Ru Su (YR)

Biostatistics Division, Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.

Catherine M Tangen (CM)

SWOG Statistical Center, Fred Hutchinson Cancer Center, Seattle, WA, USA.

Stephen N Thibodeau (SN)

Division of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.

Duncan C Thomas (DC)

Department of Population and Public Health Sciences & USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Cornelia M Ulrich (CM)

Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
Department of Population Health Sciences, University of Utah, Salt Lake City, UH, USA.

Caroline Y Um (CY)

Department of Population Science, American Cancer Society, Atlanta, GA, USA.
ORCID: 0000-0001-5449-6230

Franzel J B van Duijnhoven (FJB)

Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, The Netherlands.

Kala Visvanathan (K)

Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA.
ORCID: 0000-0002-0582-8005

Pavel Vodicka (P)

Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic.
Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic.
Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic.

Ludmila Vodickova (L)

Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic.
Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic.
Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic.

Emily White (E)

Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA.

Alicja Wolk (A)

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
ORCID: 0000-0001-7387-6845

Michael O Woods (MO)

Memorial University of Newfoundland, Discipline of Genetics, St. John's, NL, Canada.

Conghui Qu (C)

Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.

Anshul Kundaje (A)

Department of Genetics, Stanford University, Stanford, CA, USA.
Department of Computer Science, Stanford University, Stanford, CA, USA.
ORCID: 0000-0003-3084-2287

Li Hsu (L)

Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Department of Biostatistics, University of Washington, Seattle, WA, USA.

W James Gauderman (WJ)

Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Marc J Gunter (MJ)

Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France.
School of Public Health, Imperial College London, London, United Kingdom.

Ulrike Peters (U)

Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA.

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Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
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Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
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Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Probing the diabetes and colorectal cancer...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Interaction entre gènes et environnement › Probing the diabetes and colorectal cancer...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › Probing the diabetes and colorectal cancer...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Probing the diabetes and colorectal cancer...
questionsmedicales.fr › Maladies endocriniennes › Diabète › Probing the diabetes and colorectal cancer...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies du rectum › Tumeurs colorectales › Probing the diabetes and colorectal cancer...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › Probing the diabetes and colorectal cancer...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Probing the diabetes and colorectal cancer...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cytosquelette › Protéines des microfilaments › Probing the diabetes and colorectal cancer...