Impact of corticosteroid administration on the response of exposed dental pulp to capping with bioactive cements-experimental study on mongrel dogs.
Animals
Dogs
Male
Dental Pulp
Pulpitis
/ drug therapy
Dental Pulp Capping
/ methods
Calcium Compounds
/ pharmacology
Silicates
/ pharmacology
Adrenal Cortex Hormones
/ pharmacology
Oxides
/ pharmacology
Pulp Capping and Pulpectomy Agents
/ pharmacology
Drug Combinations
Aluminum Compounds
/ pharmacology
Corticosteroid
Direct pulp capping technique
Dogs’ teeth
Pulp capping material
Journal
BMC oral health
ISSN: 1472-6831
Titre abrégé: BMC Oral Health
Pays: England
ID NLM: 101088684
Informations de publication
Date de publication:
26 06 2023
26 06 2023
Historique:
received:
09
05
2023
accepted:
07
06
2023
medline:
28
6
2023
pubmed:
27
6
2023
entrez:
26
6
2023
Statut:
epublish
Résumé
Corticosteroids are commonly used as a treatment for a variety of pathological conditions, however, systemic corticosteroid administration has adverse effects including impaired immune response and wound healing. Such complications may affect pulp healing after direct pulp capping. The current study evaluated the influence of corticosteroids on the healing ability of exposed dogs' dental pulps after direct pulp capping (DPC) with bioactive materials. Ten healthy male dogs were assigned randomly into two groups, 5 dogs each: group I represent the control group which did not receive any medication, and group II was given corticosteroid for 45 days before DPC and till the dogs were euthanized (n = 75 teeth for each group). Following mechanical exposure, the pulps were randomly capped with either Ca(OH) The corticosteroid-treated group revealed no significant difference compared to the control group concerning the pulp healing response (P > 0.05). Both Biodentine and MTA-treated specimens revealed significant differences with Ca(OH) Direct pulp capping technique whenever indicated in subjects treated with corticosteroid immunosuppressive drugs like prednisone performed well in aseptic conditions especially when capped with bioactive materials.
Sections du résumé
BACKGROUND
Corticosteroids are commonly used as a treatment for a variety of pathological conditions, however, systemic corticosteroid administration has adverse effects including impaired immune response and wound healing. Such complications may affect pulp healing after direct pulp capping. The current study evaluated the influence of corticosteroids on the healing ability of exposed dogs' dental pulps after direct pulp capping (DPC) with bioactive materials.
METHODS
Ten healthy male dogs were assigned randomly into two groups, 5 dogs each: group I represent the control group which did not receive any medication, and group II was given corticosteroid for 45 days before DPC and till the dogs were euthanized (n = 75 teeth for each group). Following mechanical exposure, the pulps were randomly capped with either Ca(OH)
RESULTS
The corticosteroid-treated group revealed no significant difference compared to the control group concerning the pulp healing response (P > 0.05). Both Biodentine and MTA-treated specimens revealed significant differences with Ca(OH)
CONCLUSIONS
Direct pulp capping technique whenever indicated in subjects treated with corticosteroid immunosuppressive drugs like prednisone performed well in aseptic conditions especially when capped with bioactive materials.
Identifiants
pubmed: 37365555
doi: 10.1186/s12903-023-03119-3
pii: 10.1186/s12903-023-03119-3
pmc: PMC10294540
doi:
Substances chimiques
tricalcium silicate
404G39282C
Calcium Compounds
0
Silicates
0
Adrenal Cortex Hormones
0
Oxides
0
Pulp Capping and Pulpectomy Agents
0
Drug Combinations
0
Aluminum Compounds
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
423Informations de copyright
© 2023. The Author(s).
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