Synthesis, α-Glucosidase inhibitory activity and docking studies of Novel Ethyl 1,2,3-triazol-4-ylmethylthio-5,6-diphenylpyridazine-4-carboxylate derivatives.

Click reaction Copper iodide Diabetes Pyridizine Triazole α-Glucosidase

Journal

BMC chemistry
ISSN: 2661-801X
Titre abrégé: BMC Chem
Pays: Switzerland
ID NLM: 101741142

Informations de publication

Date de publication:
26 Jun 2023
Historique:
received: 24 10 2022
accepted: 30 05 2023
medline: 27 6 2023
pubmed: 27 6 2023
entrez: 26 6 2023
Statut: epublish

Résumé

In this work, a novel series of pyridazine-triazole hybrid molecules were prepared and evaluated as inhibitors of rat intestinal α-glucosidase enzyme. Amongst all newly synthesized compounds, 10k showed good inhibition in the series with IC

Identifiants

pubmed: 37365646
doi: 10.1186/s13065-023-00973-8
pii: 10.1186/s13065-023-00973-8
pmc: PMC10294378
doi:

Types de publication

Journal Article

Langues

eng

Pagination

66

Subventions

Organisme : National Institute for Medical Research Development (NIMAD)
ID : 995866

Informations de copyright

© 2023. The Author(s).

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Auteurs

Loghman Firoozpour (L)

Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Setareh Moghimi (S)

Drug Design and Development Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran.

Somayeh Salarinejad (S)

Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Mahsa Toolabi (M)

Department of Medicinal Chemistry, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Mahdi Rafsanjani (M)

Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Roya Pakrad (R)

Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran.

Farzaneh Salmani (F)

Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran.

Seyed Mohammad Shokrolahi (SM)

Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran.

Seyed Esmail Sadat Ebrahimi (SE)

Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Saeed Karima (S)

Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran.

Alireza Foroumadi (A)

Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. aforoumadi@yahoo.com.
Drug Design and Development Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran. aforoumadi@yahoo.com.

Classifications MeSH