The survival outcomes of prophylactic lateral neck dissection for medullary thyroid carcinoma, a retrospective cohort study.
American Thyroid Association
calcitonin
prophylactic neck dissection
regional metastases
Journal
Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery
ISSN: 1749-4486
Titre abrégé: Clin Otolaryngol
Pays: England
ID NLM: 101247023
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
revised:
05
01
2023
received:
06
10
2022
accepted:
05
03
2023
medline:
15
8
2023
pubmed:
27
6
2023
entrez:
27
6
2023
Statut:
ppublish
Résumé
The purpose of this study was to evaluate the benefits of prophylactic lymph node dissection in medullary thyroid carcinoma (MTC) patients without radiographically lateral neck metastases. Retrospective cohort study. Tianjin Medical University Cancer Institute and Hospital. Patients who underwent primary surgery for MTC between 2011 and 2019 and without structural disease of the lateral neck preoperatively. Locoregional recurrence, disease-free survival (DFS), and overall survival (OS) were examined. The patients were divided into two groups: the central lymph node dissection (CLND) only group and the prophylactic lateral lymph node dissection (PLND) group, which included CLND and ipsilateral lateral lymph node dissection (LLND). A total of 89 patients were included: 71 patients in the CLND group and 18 patients in the PLND group. Although there were no significant differences in age, gender, multifocality, capsule invasion or TNM stage between the two groups, the tumour size and preoperative median calcitonin levels were different. The recurrence rate was 4.2% for the CLND group and 5.6% for the PLND group (p > 0.05). DFS among the CLND and PLND groups was 95.4% and 94.4%, and OS among the groups was 100% and 94.1% (p > 0.05) at 5 years. The biochemical cure rates were similar. PLND in the absence of structural disease of the lateral neck preoperatively is not associated with improved survival in patients with sporadic MTC.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
734-739Subventions
Organisme : Beijing-Tianjin-Hebei Basic Research Cooperation Project
ID : 20JCZXJC00120
Organisme : National Natural Science Foundation of China
ID : 82103386
Organisme : National Natural Science Foundation of China
ID : 82172821
Organisme : National Natural Science Foundation of China
ID : 82272721
Organisme : The Science &Technology Development Fund of Tianjin Education Commission for Higher Education
ID : 2021ZD033
Organisme : Tianjin Medical Key Discipline(Specialty) Construction Project
ID : TJYXZDXK-058B
Organisme : Tianjin Medical University Cancer Institute & Hospital innovation research fund
ID : 2002
Organisme : Tianjin Municipal Science and Technology Project
ID : 19JCYBJC27400
Organisme : Tianjin Municipal Science and Technology Project
ID : 21JCZDJC00360
Organisme : Tianjin Health Research Project
ID : TJWJ2022XK024
Organisme : Tianjin Binhai New Area Health Commission Project
ID : 2022BWKQ027
Informations de copyright
© 2023 John Wiley & Sons Ltd.
Références
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