A Fast and Reliable Method Based on QCM-D Instrumentation for the Screening of Nanoparticle/Blood Protein Interactions.
QCM-D
blood proteins
hemocompatibility
nanoparticles
protein corona
Journal
Biosensors
ISSN: 2079-6374
Titre abrégé: Biosensors (Basel)
Pays: Switzerland
ID NLM: 101609191
Informations de publication
Date de publication:
02 Jun 2023
02 Jun 2023
Historique:
received:
12
04
2023
revised:
24
05
2023
accepted:
31
05
2023
medline:
29
6
2023
pubmed:
27
6
2023
entrez:
27
6
2023
Statut:
epublish
Résumé
The interactions that nanoparticles have with blood proteins are crucial for their fate in vivo. Such interactions result in the formation of the protein corona around the nanoparticles, and studying them aids in nanoparticle optimization. Quartz crystal microbalance with dissipation monitoring (QCM-D) can be used for this study. The present work proposes a QCM-D method to study the interactions on polymeric nanoparticles with three different human blood proteins (albumin, fibrinogen and γ-globulin) by monitoring the frequency shifts of sensors immobilizing the selected proteins. Bare PEGylated and surfactant-coated poly-(D,L-lactide-
Identifiants
pubmed: 37366972
pii: bios13060607
doi: 10.3390/bios13060607
pmc: PMC10296749
pii:
doi:
Substances chimiques
Protein Corona
0
Fibrinogen
9001-32-5
Albumins
0
Surface-Active Agents
0
gamma-Globulins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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