Fitness-Dependent, Mild Mutagenic Activity of Sofosbuvir for Hepatitis C Virus.
antiviral agent
lethal defection
ultradeep sequencing
viral fitness
viral quasispecies
Journal
Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061
Informations de publication
Date de publication:
18 07 2023
18 07 2023
Historique:
pmc-release:
27
12
2023
medline:
17
7
2023
pubmed:
27
6
2023
entrez:
27
6
2023
Statut:
ppublish
Résumé
The concept of a mild mutagen was coined to describe a minor mutagenic activity exhibited by some nucleoside analogues that potentiated their efficacy as antiretroviral agents. In the present study, we report the mild mutagen activity of sofosbuvir (SOF) for hepatitis C virus (HCV). Serial passages of HCV in human hepatoma cells, in the presence of SOF at a concentration well below its cytotoxic concentration 50 (CC
Identifiants
pubmed: 37367486
doi: 10.1128/aac.00394-23
pmc: PMC10353389
doi:
Substances chimiques
Sofosbuvir
WJ6CA3ZU8B
Mutagens
0
Antiviral Agents
0
Ribavirin
49717AWG6K
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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