Fungal Vaccine Development: State of the Art and Perspectives Using Immunoinformatics.
bioinformatic
fungi
neglected disease
systemic mycosis
vaccine
Journal
Journal of fungi (Basel, Switzerland)
ISSN: 2309-608X
Titre abrégé: J Fungi (Basel)
Pays: Switzerland
ID NLM: 101671827
Informations de publication
Date de publication:
31 May 2023
31 May 2023
Historique:
received:
03
03
2023
revised:
12
05
2023
accepted:
19
05
2023
medline:
27
6
2023
pubmed:
27
6
2023
entrez:
27
6
2023
Statut:
epublish
Résumé
Fungal infections represent a serious global health problem, causing damage to health and the economy on the scale of millions. Although vaccines are the most effective therapeutic approach used to combat infectious agents, at the moment, no fungal vaccine has been approved for use in humans. However, the scientific community has been working hard to overcome this challenge. In this sense, we aim to describe here an update on the development of fungal vaccines and the progress of methodological and experimental immunotherapies against fungal infections. In addition, advances in immunoinformatic tools are described as an important aid by which to overcome the difficulty of achieving success in fungal vaccine development. In silico approaches are great options for the most important and difficult questions regarding the attainment of an efficient fungal vaccine. Here, we suggest how bioinformatic tools could contribute, considering the main challenges, to an effective fungal vaccine.
Identifiants
pubmed: 37367569
pii: jof9060633
doi: 10.3390/jof9060633
pmc: PMC10301004
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : National Council for Scientific and Technological Development
ID : 408042/2021-4
Organisme : Instituto Nacional de Ciência e Tecnologia
ID : IPH: INCT-IPH
Organisme : Fundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de Mato Grosso do Sul
ID : UNDECT/DECIT-MS/CNPq/SES No. 03/2016-PPSUS-MS, PPSUS/FUNDECT No. 08/2020;
Organisme : Coordenação de Aperfeicoamento de Pessoal de Nível Superior
ID : Finance Code 001
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