Smart Radiotherapy Biomaterials for Image-Guided In Situ Cancer Vaccination.
abscopal effect
cancer
image-guided radiotherapy
in situ vaccination
radio-immunotherapy
smart radiotherapy biomaterials
Journal
Nanomaterials (Basel, Switzerland)
ISSN: 2079-4991
Titre abrégé: Nanomaterials (Basel)
Pays: Switzerland
ID NLM: 101610216
Informations de publication
Date de publication:
12 Jun 2023
12 Jun 2023
Historique:
received:
10
05
2023
revised:
24
05
2023
accepted:
26
05
2023
medline:
27
6
2023
pubmed:
27
6
2023
entrez:
27
6
2023
Statut:
epublish
Résumé
Recent studies have highlighted the potential of smart radiotherapy biomaterials (SRBs) for combining radiotherapy and immunotherapy. These SRBs include smart fiducial markers and smart nanoparticles made with high atomic number materials that can provide requisite image contrast during radiotherapy, increase tumor immunogenicity, and provide sustained local delivery of immunotherapy. Here, we review the state-of-the-art in this area of research, the challenges and opportunities, with a focus on in situ vaccination to expand the role of radiotherapy in the treatment of both local and metastatic disease. A roadmap for clinical translation is outlined with a focus on specific cancers where such an approach is readily translatable or will have the highest impact. The potential of FLASH radiotherapy to synergize with SRBs is discussed including prospects for using SRBs in place of currently used inert radiotherapy biomaterials such as fiducial markers, or spacers. While the bulk of this review focuses on the last decade, in some cases, relevant foundational work extends as far back as the last two and half decades.
Identifiants
pubmed: 37368273
pii: nano13121844
doi: 10.3390/nano13121844
pmc: PMC10303169
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : NCI NIH HHS
ID : R01 CA239042
Pays : United States
Organisme : NIH HHS
ID : R01CA239042
Pays : United States
Références
Int J Mol Sci. 2020 Sep 05;21(18):
pubmed: 32899466
Eur J Cancer. 2021 May;148:36-47
pubmed: 33721705
JAMA Netw Open. 2021 Jan 4;4(1):e2033761
pubmed: 33464318
Cell Res. 2017 Jan;27(1):74-95
pubmed: 28025976
World Neurosurg. 2018 Aug;116:505-517
pubmed: 30049045
Front Oncol. 2021 Feb 26;11:601820
pubmed: 33718149
BMJ Open. 2019 Feb 11;9(2):e023591
pubmed: 30755445
Int J Radiat Oncol Biol Phys. 2022 Feb 1;112(2):475-486
pubmed: 34530092
Phys Med Biol. 2015 Sep 21;60(18):7035-43
pubmed: 26309064
Med Phys. 1999 Oct;26(10):2054-76
pubmed: 10535622
Pract Radiat Oncol. 2020 Nov - Dec;10(6):434-442
pubmed: 31988039
Invest Radiol. 1999 Feb;34(2):126-33
pubmed: 9951792
Nanomaterials (Basel). 2020 Nov 13;10(11):
pubmed: 33202903
Int Immunol. 2019 Jul 13;31(7):465-475
pubmed: 30753483
JCO Glob Oncol. 2020 Apr;6:667-678
pubmed: 32343628
Med Phys. 1993 Mar-Apr;20(2 Pt 2):551-67
pubmed: 8492764
ACS Nano. 2018 Dec 26;12(12):12096-12108
pubmed: 30444351
Front Oncol. 2018 Mar 12;8:56
pubmed: 29594038
Theranostics. 2020 Jan 1;10(3):1319-1331
pubmed: 31938067
Hum Vaccin Immunother. 2014;10(11):3415-24
pubmed: 25483656
Crit Rev Oncog. 2013;18(1-2):43-73
pubmed: 23237552
Radiother Oncol. 2019 Oct;139:11-17
pubmed: 31253466
Oncology (Williston Park). 2015 Sep;29(9):633-40
pubmed: 26384798
Sci Rep. 2016 Nov 07;6:36147
pubmed: 27819335
Int J Radiat Oncol Biol Phys. 2017 Mar 1;97(3):624-637
pubmed: 28126309
Nat Rev Cancer. 2018 May;18(5):313-322
pubmed: 29449659
Radiother Oncol. 2017 Mar;122(3):393-399
pubmed: 28104299
Immunotherapy. 2011 Mar;3(3):349-70
pubmed: 21395378
Technol Cancer Res Treat. 2015 Jun;14(3):298-304
pubmed: 25230715
Am Soc Clin Oncol Educ Book. 2020 May;40:1-6
pubmed: 32412805
Clin Transl Radiat Oncol. 2022 Nov 04;38:90-95
pubmed: 36407490
Br J Radiol. 2019 Jan;92(1093):20180365
pubmed: 30226413
Front Oncol. 2022 Dec 21;12:1020088
pubmed: 36620560
J Pers Med. 2021 Aug 23;11(8):
pubmed: 34442469
BMC Pulm Med. 2018 Aug 6;18(1):129
pubmed: 30081885
Front Immunol. 2015 Oct 08;6:505
pubmed: 26500646
Cancers (Basel). 2019 Aug 22;11(9):
pubmed: 31443339
BMJ. 2015 Apr 22;350:h988
pubmed: 25904595
Nat Biomed Eng. 2019 Oct;3(10):768-782
pubmed: 31406259
Biomaterials. 2010 Nov;31(32):8419-25
pubmed: 20701966
Clin Oncol (R Coll Radiol). 2019 Jul;31(7):407-415
pubmed: 31010708
J Radiat Res. 2017 Jul 1;58(4):446-455
pubmed: 28339788
Front Oncol. 2021 Oct 26;11:711078
pubmed: 34765538
Med Phys. 2015 Jun;42(6):2818-26
pubmed: 26127034
Int J Part Ther. 2018 Summer;5(1):84-93
pubmed: 31773022
Radiother Oncol. 2019 Oct;139:18-22
pubmed: 31303340
Front Oncol. 2017 Sep 19;7:208
pubmed: 28971063
Med Phys. 2018 Jan;45(1):37-47
pubmed: 29136287
Carbohydr Polym. 2023 Mar 15;304:120510
pubmed: 36641174
Cancer Immunol Immunother. 2014 Jan;63(1):29-36
pubmed: 24052136
Oncotarget. 2017 Mar 28;8(13):21472-21482
pubmed: 28423524
Proc Natl Acad Sci U S A. 2021 Jan 12;118(2):
pubmed: 33431572
Clin Cancer Res. 2019 Jan 1;25(1):35-42
pubmed: 29875213
Oncotarget. 2017 Jun 8;8(37):62742-62758
pubmed: 28977985
Clin Cancer Res. 2020 Jun 15;26(12):2777-2782
pubmed: 32047000
Radiat Res. 2012 Dec;178(6):604-8
pubmed: 23148509
Lancet Oncol. 2015 Jul;16(7):742-3
pubmed: 26095779
Med Phys. 2020 Jun;47(6):e255-2720
pubmed: 32634280
Cancer Nanotechnol. 2015;6(1):4
pubmed: 26345984
Nat Biomed Eng. 2018 Aug;2(8):578-588
pubmed: 31015631
N Engl J Med. 2022 Oct 27;387(17):1557-1568
pubmed: 36094839
Int J Radiat Oncol Biol Phys. 2023 Jul 1;116(3):655-665
pubmed: 36563907
Cancers (Basel). 2020 May 18;12(5):
pubmed: 32443537