The effect of weight loss on whole-body and tissue-specific insulin sensitivity and hepatic lipid content and composition: SWEET substudy.
Journal
Obesity (Silver Spring, Md.)
ISSN: 1930-739X
Titre abrégé: Obesity (Silver Spring)
Pays: United States
ID NLM: 101264860
Informations de publication
Date de publication:
07 2023
07 2023
Historique:
revised:
22
02
2023
received:
26
10
2022
accepted:
13
03
2023
medline:
29
6
2023
pubmed:
27
6
2023
entrez:
27
6
2023
Statut:
ppublish
Résumé
This study (1) investigated the effect of weight loss on whole-body and tissue-specific insulin sensitivity and on intrahepatic lipid (IHL) content and composition and (2) investigated the association between weight-loss-induced changes in insulin sensitivity and IHL content in individuals with overweight or obesity. In this secondary analysis of the European SWEET project, 50 adults (age 18-65 years) with overweight or obesity (BMI ≥ 25 kg/m The LED reduced body weight (p < 0.001). This was accompanied by increased Matsuda index and reduced HIRI (both p < 0.001) but no change in MISI (p = 0.260). Weight loss decreased IHL content (mean [SEM], 3.9% [0.7%] vs. 1.6% [0.5%], p < 0.001) and the hepatic saturated fatty acid fraction (41.0% [1.5%] vs. 36.6% [1.9%], p = 0.039). The reduced IHL content was associated with an improvement in HIRI (r = 0.402, p = 0.025). Weight loss decreased IHL content and the hepatic saturated fatty acid fraction. The decrease in IHL content was associated with weight-loss-induced improvement in hepatic insulin sensitivity in individuals with overweight or obesity.
Substances chimiques
Insulin
0
Lipids
0
Fatty Acids
0
Banques de données
ClinicalTrials.gov
['NCT04226911']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1745-1754Informations de copyright
© 2023 The Authors. Obesity published by Wiley Periodicals LLC on behalf of The Obesity Society.
Références
World Health Organization. Noncommunicable Diseases Country Profiles 2018. WHO; 2018.
Trouwborst I, Bowser S, Goossens G, Blaak E. Ectopic fat accumulation in distinct insulin resistant phenotypes; targets for personalized nutritional interventions. Front Nutr. 2018;5:77. doi:10.3389/fnut.2018.00077
Yki-Järvinen H. Fat in the liver and insulin resistance. Ann Med. 2005;37:347-356.
Christensen P, Meinert Larsen T, Westerterp-Plantenga M, et al. Men and women respond differently to rapid weight loss: metabolic outcomes of a multi-centre intervention study after a low-energy diet in 2500 overweight, individuals with pre-diabetes (PREVIEW). Diabetes Obes Metab. 2018;20:2840-2851.
Viljanen A, Iozzo P, Borra R, et al. Effect of weight loss on liver free fatty acid uptake and hepatic insulin resistance. J Clin Endocrinol Metab. 2009;94:50-55.
Kirk E, Reeds D, Finck B, Mayurranjan S, Patterson B, Klein S. Dietary fat and carbohydrates differentially alter insulin sensitivity during caloric restriction. Gastroenterology. 2009;136:1552-1560.
Vitola B, Deivanayagam S, Stein R, et al. Weight loss reduces liver fat and improves hepatic and skeletal muscle insulin sensitivity in obese adolescents. Obesity (Silver Spring). 2009;17:1744-1748.
Rossi A, Fantin F, Zamboni G, et al. Effect of moderate weight loss on hepatic, pancreatic and visceral lipids in obese subjects. Nutr Diabetes. 2012;2:e32. doi:10.1038/nutd.2012.5
Tiikkainen M, Bergholm R, Vehkavaara S, et al. Effects of identical weight loss on body composition and features of insulin resistance in obese women with high and low liver fat content. Diabetes. 2003;52:701-707.
Haufe S, Haas V, Utz W, et al. Long-lasting improvements in liver fat and metabolism despite body weight regain after dietary weight loss. Diabetes Care. 2013;36:3786-3792.
Magkos F, Fraterrigo G, Yoshino J, et al. Effects of moderate and subsequent progressive weight loss on metabolic function and adipose tissue biology in humans with obesity. Cell Metab. 2016;23:591-601.
Meex R, Watt M. Hepatokines: linking nonalcoholic fatty liver disease and insulin resistance. Nat Rev Endocrinol. 2017;13:509-520.
Stefan N, Staiger H, Häring H-U. Dissociation between fatty liver and insulin resistance: the role of adipose triacylglycerol lipase. Diabetologia. 2011;54:7-9.
Amaro A, Fabbrini E, Kars M, et al. Dissociation between intrahepatic triglyceride content and insulin resistance in familial hypobetalipoproteinemia. Gastroenterology. 2010;139:149-153.
Visser M, Lammers N, Nederveen A, et al. Hepatic steatosis does not cause insulin resistance in people with familial hypobetalipoproteinaemia. Diabetologia. 2011;54:2113-2121.
Benhamed F, Denechaud P, Lemoine M, et al. The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans. J Clin Invest. 2012;122:2176-2194.
Listenberger L, Han X, Lewis S, et al. Triglyceride accumulation protects against fatty acid-induced lipotoxicity. Proc Natl Acad Sci U S A. 2003;100:3077-3082.
Ariyama H, Kono N, Matsuda S, Inoue T, Arai H. Decrease in membrane phospholipid unsaturation induces unfolded protein response. J Biol Chem. 2010;285:22027-22035.
Roumans K, Lindeboom L, Veeraiah P, et al. Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance. Nat Commun. 2020;11:1891. doi:10.1038/s41467-020-15684-0
Araya J, Rodrigo R, Videla L, et al. Increase in long-chain polyunsaturated fatty acid n-6/n-3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease. Clin Sci (Lond). 2004;106:635-643.
Puri P, Baillie R, Wiest M, et al. A lipidomic analysis of nonalcoholic fatty liver disease. Hepatology. 2007;46:1081-1090.
Kjølbaek L, Manios Y, Blaak E, et al. Protocol for a multicentre, parallel, randomised, controlled, trial on the effect of sweeteners and sweetness enhancers on health, obesity and safety in overweight adults and children. The SWEET project. BMJ Open. 2022;12:e061075. doi:10.1136/bmjopen-2022-061075
Matsuda M, DeFronzo RA. Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care. 1999;22:1462-1470.
Abdul-Ghani M, Matsuda M, Balas B, DeFronzo R. Muscle and liver insulin resistance indexes derived from the oral glucose tolerance test. Diabetes Care. 2007;30:89-94.
O'Donovan S, Lenz M, Goossens G, et al. Improved quantification of muscle insulin sensitivity using oral glucose tolerance test data: the MISI calculator. Sci Rep. 2019;9:9388. doi:10.1038/s41598-019-45858-w
Utzschneider K, Kahn S. The role of insulin resistance in nonalcoholic fatty liver disease. J Clin Endocrinol Metab. 2006;91:4753-4761.
Eissing L, Scherer T, Tödter K, et al. De novo lipogenesis in human fat and liver is linked to ChREBP-β and metabolic health. Nat Commun. 2013;4:1528. doi:10.1038/ncomms2537
Kröger J, Schulze M. Recent insights into the relation of Δ5 desaturase and Δ6 desaturase activity to the development of type 2 diabetes. Curr Opin Lipidol. 2012;23:4-10.
Walle P, Takkunen M, Männistö V, et al. Alterations in fatty acid metabolism in response to obesity surgery combined with dietary counseling. Nutr Diabetes. 2017;7:e285. doi:10.1038/nutd.2017.33
Johnson N, Walton D, Sachinwalla T, et al. Noninvasive assessment of hepatic lipid composition: advancing understanding and management of fatty liver disorders. Hepatology. 2008;47:1513-1523.
Schram M, Sep S, van der Kallen C, et al. The Maastricht study: an extensive phenotyping study on determinants of type 2 diabetes, its complications and its comorbidities. Eur J Epidemiol. 2014;29:439-451.
Sesti G, Folli F, Perego L, Hribal ML, Pontiroli AE. Effects of weight loss in metabolically healthy obese subjects after laparoscopic adjustable gastric banding and hypocaloric diet. PLoS One. 2011;6:e17737. doi:10.1371/journal.pone.0017737
Karelis AD, Messier V, Brochu M, Rabasa-Lhoret R. Metabolically healthy but obese women: effect of an energy-restricted diet. Diabetologia. 2008;51:1752-1754.
Nauck M, Meier J. The incretin effect in healthy individuals and those with type 2 diabetes: physiology, pathophysiology, and response to therapeutic interventions. Lancet Diabetes Endocrinol. 2016;4:525-536.
Wilson M, Ross R. Measurement of muscle insulin sensitivity in obese men. Diabetes Metab. 2014;40:161-164.
Bastard J, Faraj M, Karelis A. Muscle and liver insulin resistance indexes derived from the oral glucose tolerance test; Response to Abdul-Ghani et al. Diabetes Care. 2007;30:e83.
Vogelzangs N, van der Kallen C, van Greevenbroek M, et al. Metabolic profiling of tissue-specific insulin resistance in human obesity: results from the Diogenes study and the Maastricht study. Int J Obes (Lond). 2020;44:1376-1386.
van der Kolk B, Vogelzangs N, Jocken J, et al. Plasma lipid profiling of tissue-specific insulin resistance in human obesity. Int J Obes (Lond). 2019;43:989-998.