Molecular Profile of Canine Hemangiosarcoma and Potential Novel Therapeutic Targets.
CDKN2A
NRAS
PIK3CA
PTEN
TP53
VEGF
angiosarcoma
dog
Journal
Veterinary sciences
ISSN: 2306-7381
Titre abrégé: Vet Sci
Pays: Switzerland
ID NLM: 101680127
Informations de publication
Date de publication:
05 Jun 2023
05 Jun 2023
Historique:
received:
14
05
2023
revised:
31
05
2023
accepted:
02
06
2023
medline:
27
6
2023
pubmed:
27
6
2023
entrez:
27
6
2023
Statut:
epublish
Résumé
Canine hemangiosarcoma (HSA) is a relatively common neoplasia, occurring mainly in the skin, spleen, liver and right atrium. Despite the numerous studies investigating the treatment of canine HSA, no significant improvement in survival has been achieved in the last 20 years. Advancements in genetic and molecular profiling presented molecular similarities between canine HSA and human angiosarcoma. It could therefore serve as a valuable model for investigating new and more effective treatments in people and dogs. The most common genetic abnormalities in canine HSA have been found in the phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) and neuroblastoma RAS viral oncogene homolog (NRAS) pathways. Mutations are also found in tumor protein p53 (TP53), phosphatase and tensin homolog (PTEN) and cyclin dependent kinase inhibitor 2A (CDKN2A). Known abnormal protein expression could be exploited to trial new target treatments that could be beneficial for both canine and human patients. Despite the high expression of vascular endothelial growth factor (VEGF) and its receptor (VEGFR), no correlation with overall survival time has ever been found. In this review, we explore the most recent developments in molecular profiling in canine HSA and discuss their possible applications in the prognosis and treatment of this fatal disease.
Identifiants
pubmed: 37368773
pii: vetsci10060387
doi: 10.3390/vetsci10060387
pmc: PMC10302982
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
Cell Cycle. 2014;13(9):1501-7
pubmed: 24626176
Mol Cancer Res. 2019 Dec;17(12):2410-2421
pubmed: 31570656
Am J Pathol. 2014 Apr;184(4):985-995
pubmed: 24525151
PLoS One. 2016 Jun 08;11(6):e0157176
pubmed: 27276060
BMC Cancer. 2018 Oct 11;18(1):963
pubmed: 30305054
Medicine (Baltimore). 2021 Jul 30;100(30):e26779
pubmed: 34397726
Vet Comp Oncol. 2017 Mar;15(1):25-35
pubmed: 25623994
Nat Commun. 2021 Aug 3;12(1):4670
pubmed: 34344882
BMC Vet Res. 2022 Aug 31;18(1):329
pubmed: 36045415
Carcinogenesis. 1998 Jun;19(6):959-63
pubmed: 9667731
BMC Vet Res. 2012 Jul 29;8:128
pubmed: 22839755
J Vet Med Sci. 2016 May 3;78(4):649-56
pubmed: 26685984
Front Oncol. 2014 Mar 03;4:35
pubmed: 24624362
Chromosome Res. 2014 Sep;22(3):305-19
pubmed: 24599718
Nat Rev Urol. 2018 Apr;15(4):222-234
pubmed: 29460925
Res Vet Sci. 2008 Oct;85(2):383-8
pubmed: 18082231
Cell Death Dis. 2018 Jul 3;9(7):744
pubmed: 29970908
Cell. 2011 Mar 4;144(5):646-74
pubmed: 21376230
Cancers (Basel). 2020 May 18;12(5):
pubmed: 32443457
Can Vet J. 2018 Sep;59(9):967-972
pubmed: 30197439
PLoS One. 2022 Dec 22;17(12):e0279594
pubmed: 36548371
Vet Comp Oncol. 2022 Dec;20(4):901-905
pubmed: 35535636
Cancer Res. 2008 Oct 1;68(19):8127-36
pubmed: 18829572
Hum Pathol. 2020 Aug;102:60-69
pubmed: 32540221
J Am Vet Med Assoc. 2021 Mar 15;258(6):630-637
pubmed: 33683962
Vet Sci. 2015 Nov 06;2(4):388-405
pubmed: 29061949
Memo. 2017;10(4):190-193
pubmed: 29250195
Cancers (Basel). 2017 Apr 28;9(5):
pubmed: 28452926
Semin Cancer Biol. 2022 Aug;83:452-471
pubmed: 32814115
J Am Anim Hosp Assoc. 2017 Nov/Dec;53(6):304-312
pubmed: 28892429
PLoS One. 2020 Mar 25;15(3):e0229728
pubmed: 32210430
Mol Cancer Res. 2021 May;19(5):847-861
pubmed: 33649193
Target Oncol. 2014 Sep;9(3):273-7
pubmed: 24218035
Vet Comp Oncol. 2022 Dec;20(4):805-816
pubmed: 35568976
Front Oncol. 2023 Jan 27;13:1100602
pubmed: 36816969
Exp Cell Res. 2014 Apr 15;323(1):155-164
pubmed: 24582862
NPJ Precis Oncol. 2023 Jan 19;7(1):8
pubmed: 36658200
Science. 2018 Jan 12;359(6372):
pubmed: 29326244
EBioMedicine. 2016 Jun;8:30-39
pubmed: 27428416
J Am Vet Med Assoc. 2007 Nov 15;231(10):1550-7
pubmed: 18021000
BMC Vet Res. 2020 Nov 18;16(1):447
pubmed: 33208160
Rom J Morphol Embryol. 2018;59(2):455-467
pubmed: 30173249
Int J Mol Sci. 2020 Jul 27;21(15):
pubmed: 32727102
Cancer Gene Ther. 2019 Sep;26(9-10):282-291
pubmed: 30670791
Semin Cancer Biol. 2022 Oct;85:69-94
pubmed: 34175443
Ann Pharmacother. 2017 Feb;51(2):146-153
pubmed: 27701080
Cancer Treat Res Commun. 2021;26:100296
pubmed: 33421822
Aging (Albany NY). 2019 Dec 19;11(24):12043-12056
pubmed: 31857500
BMC Vet Res. 2020 Jul 13;16(1):239
pubmed: 32660487
Animals (Basel). 2021 Jul 12;11(7):
pubmed: 34359206
Front Vet Sci. 2022 May 19;9:888483
pubmed: 35664857
Cells. 2020 Jan 13;9(1):
pubmed: 31941155
Semin Cancer Biol. 2019 Dec;59:36-49
pubmed: 30742905
J Vet Intern Med. 1994 Sep-Oct;8(5):345-8
pubmed: 7837111
PLoS One. 2013;8(2):e55937
pubmed: 23418479
J Am Vet Med Assoc. 2017 Sep 1;251(5):559-565
pubmed: 28828962
Can Vet J. 2020 May;61(5):499-504
pubmed: 32355348
J Surg Oncol. 1996 Mar;61(3):170-6
pubmed: 8637202
Cancer Cell Int. 2021 Feb 16;21(1):108
pubmed: 33593355
Sci Rep. 2019 Dec 9;9(1):18630
pubmed: 31819100
Exp Hematol. 2009 Jan;37(1):65-77
pubmed: 18977066
Oncol Rep. 2020 Dec;44(6):2386-2396
pubmed: 33125148
Vet Pathol. 2019 Nov;56(6):856-859
pubmed: 31422751
Nat Rev Immunol. 2023 Feb;23(2):75-89
pubmed: 35831609
Cancer Lett. 2016 Feb 28;371(2):171-81
pubmed: 26655273
Exp Hematol. 2006 Jul;34(7):870-8
pubmed: 16797414
Br J Dermatol. 2016 Oct;175(4):785-9
pubmed: 26876133
Antioxid Redox Signal. 2014 Oct 1;21(10):1516-54
pubmed: 24512032
Cancer Cell Int. 2021 Jan 20;21(1):62
pubmed: 33472628
Drugs. 2019 Jul;79(11):1249-1253
pubmed: 31256368
Sci Rep. 2019 Dec 10;9(1):18742
pubmed: 31822716
Vet Rec. 2003 Jul 19;153(3):87-9
pubmed: 12892269
J Vet Intern Med. 2019 Mar;33(2):812-819
pubmed: 30793807
Oncotarget. 2018 Apr 13;9(28):19753-19766
pubmed: 29731980
PLoS One. 2009 May 20;4(5):e5549
pubmed: 19461996
PLoS One. 2017 Nov 30;12(11):e0188667
pubmed: 29190660
Vet Surg. 2020 Aug;49(6):1154-1163
pubmed: 32562436
Clin Cancer Res. 2021 Jun 1;27(11):3005-3016
pubmed: 33753454
Biomolecules. 2019 Apr 17;9(4):
pubmed: 30999672
Vet Med (Auckl). 2017 Dec 08;8:97-102
pubmed: 30050861
J Am Vet Med Assoc. 2014 Aug 15;245(4):401-7
pubmed: 25075823
Invest New Drugs. 2013 Dec;31(6):1602-8
pubmed: 24037083
Oncol Rep. 2015 May;33(5):2345-53
pubmed: 25779537
J Vet Intern Med. 2021 Jul;35(4):1929-1934
pubmed: 34227148
Semin Cancer Biol. 2018 Oct;52(Pt 2):117-124
pubmed: 29229461
Animals (Basel). 2022 Dec 29;13(1):
pubmed: 36611747
Cancers (Basel). 2021 Feb 13;13(4):
pubmed: 33668625
Oncol Rep. 2022 Apr;47(4):
pubmed: 35234262
PLoS One. 2022 Apr 26;17(4):e0266623
pubmed: 35471999
J Cancer Res Clin Oncol. 2022 Nov 2;:
pubmed: 36322290
Vet Comp Oncol. 2012 Sep;10(3):223-35
pubmed: 22594682
Int J Mol Sci. 2021 Nov 03;22(21):
pubmed: 34769370
J Am Anim Hosp Assoc. 2014 Jul-Aug;50(4):e6-10
pubmed: 25001171
Vet Comp Oncol. 2020 Mar;18(1):43-51
pubmed: 31648405
J Comp Pathol. 2019 Jan;166:87-96
pubmed: 30691610
Cancers (Basel). 2020 Mar 20;12(3):
pubmed: 32244867
Oncol Rep. 2022 Apr;47(4):
pubmed: 35088890
Mol Cancer Ther. 2013 Sep;12(9):1701-14
pubmed: 23804705
Prev Vet Med. 2020 Aug;181:105074
pubmed: 32634752
J Vet Med Sci. 2013 Nov;75(11):1433-41
pubmed: 23811814
In Vivo. 2018 Nov-Dec;32(6):1659-1666
pubmed: 30348731
Cancer Cell Int. 2021 Dec 24;21(1):703
pubmed: 34952583
Semin Cancer Biol. 2019 Dec;59:66-79
pubmed: 30738865
Clin Transl Radiat Oncol. 2020 Nov 08;26:15-23
pubmed: 33251343
Lancet. 2008 Aug 9;372(9637):449-56
pubmed: 18653228
Sci Rep. 2022 Feb 8;12(1):2124
pubmed: 35136176
PLoS One. 2019 Nov 7;14(11):e0224945
pubmed: 31697755
J Surg Res. 2021 Jan;257:213-220
pubmed: 32858322
J Small Anim Pract. 2017 Jan;58(1):10-16
pubmed: 28094857
Exp Cell Res. 2020 Mar 1;388(1):111810
pubmed: 31891684
Vet Surg. 2018 Nov;47(8):1031-1038
pubmed: 30246401
Hum Gene Ther. 2018 Feb;29(2):160-179
pubmed: 29338444
PLoS One. 2018 Jul 16;13(7):e0200634
pubmed: 30011343
Cancer Discov. 2022 Jan;12(1):31-46
pubmed: 35022204
Hum Vaccin Immunother. 2019;15(5):1111-1122
pubmed: 30888929
J Dermatol Sci. 2019 Feb;93(2):123-132
pubmed: 30704938
Mol Cancer. 2021 Jan 4;20(1):7
pubmed: 33397409
J Am Vet Med Assoc. 2015 Aug 15;247(4):393-403
pubmed: 26225611
World J Gastroenterol. 2015 Feb 7;21(5):1488-97
pubmed: 25663768
Photodiagnosis Photodyn Ther. 2019 Sep;27:39-43
pubmed: 31125768
Dis Model Mech. 2021 Jul 1;14(7):
pubmed: 34296746
Vet Comp Oncol. 2017 Dec;15(4):1598-1605
pubmed: 27714944
Vet Sci. 2020 May 20;7(2):
pubmed: 32443710
Vet Pathol. 2005 Sep;42(5):618-32
pubmed: 16145208
J Gerontol A Biol Sci Med Sci. 2018 May 9;73(6):720-728
pubmed: 29126143
J Am Anim Hosp Assoc. 2016 Jul-Aug;52(4):220-6
pubmed: 27259024
PLoS One. 2022 Jul 22;17(7):e0264986
pubmed: 35867969
Front Vet Sci. 2021 Oct 08;8:736329
pubmed: 34692810
Cancer Res. 2020 Jul 15;80(14):2969-2974
pubmed: 32209560
Am J Cancer Res. 2019 Nov 01;9(11):2303-2313
pubmed: 31815036
BMC Vet Res. 2015 Jun 11;11:131
pubmed: 26062540
Vet Comp Oncol. 2017 Jun;15(2):315-327
pubmed: 26337509
Vet Med Sci. 2016 May 16;2(3):191-199
pubmed: 29067194
Vet Comp Oncol. 2022 Sep;20(3):688-696
pubmed: 35442554