Endocytic coelomocytes are required for lifespan extension by axenic dietary restriction.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2023
2023
Historique:
received:
07
04
2023
accepted:
15
06
2023
medline:
29
6
2023
pubmed:
27
6
2023
entrez:
27
6
2023
Statut:
epublish
Résumé
A rather peculiar but very potent means of achieving longevity is through axenic dietary restriction (ADR), where animals feed on (semi-)defined culture medium in absence of any other lifeform. The little knowledge we already have on ADR is mainly derived from studies using the model organism Caenorhabditis elegans, where ADR more than doubles organismal lifespan. What is underlying this extreme longevity so far remains enigmatic, as ADR seems distinct from other forms of DR and bypasses well-known longevity factors. We here focus first on CUP-4, a protein present in the coelomocytes, which are endocytic cells with a presumed immune function. Our results show that loss of cup-4 or of the coelomocytes affects ADR-mediated longevity to a similar extent. As the coelomocytes have been suggested to have an immune function, we then investigated different central players of innate immune signalling, but could prove no causal links with axenic lifespan extension. We propose that future research focuses further on the role of the coelomocytes in endocytosis and recycling in the context of longevity.
Identifiants
pubmed: 37368903
doi: 10.1371/journal.pone.0287933
pii: PONE-D-23-10548
pmc: PMC10298762
doi:
Substances chimiques
Caenorhabditis elegans Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0287933Informations de copyright
Copyright: © 2023 Mergan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Mech Ageing Dev. 2011 Apr;132(4):210-2
pubmed: 21354440
BMC Microbiol. 2012 Mar 27;12:49
pubmed: 22452899
Cell Stress Chaperones. 2013 May;18(3):293-306
pubmed: 23117578
Genetics. 2001 Sep;159(1):133-45
pubmed: 11560892
Genetics. 2000 Apr;154(4):1597-610
pubmed: 10747056
Aging Cell. 2019 Oct;18(5):e12982
pubmed: 31215146
Nature. 2003 Jul 17;424(6946):277-83
pubmed: 12845331
Cell Rep. 2020 Apr 7;31(1):107478
pubmed: 32268082
Int J Mol Sci. 2022 Sep 29;23(19):
pubmed: 36232823
BMC Cell Biol. 2007 Dec 21;8:54
pubmed: 18154673
Virulence. 2020 Dec;11(1):39-48
pubmed: 31851866
JAMA. 2007 Mar 7;297(9):986-94
pubmed: 17341713
Nat Genet. 2001 May;28(1):64-8
pubmed: 11326278
PLoS Biol. 2010 Aug 10;8(8):e1000450
pubmed: 20711477
Mech Ageing Dev. 1977 Nov-Dec;6(6):413-29
pubmed: 926867
Nutrition. 1989 May-Jun;5(3):155-71; discussion 172
pubmed: 2520283
Sci Rep. 2018 Jan 16;8(1):857
pubmed: 29339777
PLoS Biol. 2009 Nov;7(11):e1000245
pubmed: 19924292
Dev Biol. 2005 Mar 1;279(1):244-51
pubmed: 15708572
Neurobiol Aging. 1999 Sep-Oct;20(5):487-502
pubmed: 10638522
Nat Commun. 2020 Sep 25;11(1):4865
pubmed: 32978396
Nature. 2020 Aug;584(7821):410-414
pubmed: 32641833
Curr Biol. 2005 Jun 7;15(11):1045-50
pubmed: 15936276
Nat Rev Mol Cell Biol. 2022 Jan;23(1):56-73
pubmed: 34518687
Curr Biol. 2018 Aug 20;28(16):2544-2556.e5
pubmed: 30100339
Redox Rep. 2001;6(1):15-26
pubmed: 11333111
Antioxid Redox Signal. 2013 Jul 20;19(3):321-9
pubmed: 22870907
JAMA Intern Med. 2016 Jun 1;176(6):743-52
pubmed: 27136347
Sci Rep. 2016 Aug 17;6:31713
pubmed: 27531646
PLoS Biol. 2010 May 25;8(5):e1000376
pubmed: 20520844
FEMS Microbiol Lett. 2004 May 15;234(2):281-7
pubmed: 15135534
Genetics. 2002 Jul;161(3):1101-12
pubmed: 12136014
Science. 2003 Jun 20;300(5627):1921
pubmed: 12817143
J Biol Chem. 2010 Apr 2;285(14):10832-40
pubmed: 20133945
WormBook. 2006 Feb 11;:1-11
pubmed: 18050451
Curr Biol. 2002 Jul 23;12(14):1209-14
pubmed: 12176330
Commun Biol. 2018 Apr 5;1:30
pubmed: 30271916
J Gerontol A Biol Sci Med Sci. 2019 Jul 12;74(8):1198-1205
pubmed: 29099917
Science. 2002 Jul 26;297(5581):623-6
pubmed: 12142542
Exp Cell Res. 1996 Apr 10;224(1):174-82
pubmed: 8612683
Cell Metab. 2019 May 7;29(5):1192-1205.e8
pubmed: 30905669
Exp Gerontol. 2009 Mar;44(3):190-200
pubmed: 19007875
J Parasitol. 1972 Dec;58(6):1025-36
pubmed: 4345109
Dev Cell. 2019 Apr 8;49(1):100-117.e6
pubmed: 30965033
Exp Gerontol. 2013 Oct;48(10):1014-7
pubmed: 23462461
Ageing Res Rev. 2017 Oct;39:3-14
pubmed: 28007498
Nature. 2010 Jul 22;466(7305):498-502
pubmed: 20613724
PLoS Genet. 2011 May;7(5):e1002082
pubmed: 21625567
Aging Cell. 2009 Apr;8(2):113-27
pubmed: 19239417
Mech Ageing Dev. 2006 Jan;127(1):1-7
pubmed: 16226298
Exp Gerontol. 2003 Sep;38(9):947-54
pubmed: 12954481
Traffic. 2002 Jan;3(1):11-9
pubmed: 11872138
Exp Gerontol. 2014 Oct;58:96-103
pubmed: 25066271
Int Immunopharmacol. 2010 Mar;10(3):308-15
pubmed: 20004742
FASEB J. 2010 Feb;24(2):383-92
pubmed: 19783783
Longev Healthspan. 2014 Apr 23;3:5
pubmed: 24834345
PLoS Genet. 2006 Nov 10;2(11):e183
pubmed: 17096597
Nature. 2002 Oct 24;419(6909):808-14
pubmed: 12397350
Biosci Biotechnol Biochem. 2015;79(10):1676-83
pubmed: 26027643
Semin Immunol. 2014 Aug;26(4):303-9
pubmed: 24856329