Occurrence of Carbapenemases, Extended-Spectrum Beta-Lactamases and AmpCs among Beta-Lactamase-Producing Gram-Negative Bacteria from Clinical Sources in Accra, Ghana.

Africa AmpC Ghana beta-lactamases carbapenemases extended-spectrum beta-lactamase third-generation cephalosporin resistance

Journal

Antibiotics (Basel, Switzerland)
ISSN: 2079-6382
Titre abrégé: Antibiotics (Basel)
Pays: Switzerland
ID NLM: 101637404

Informations de publication

Date de publication:
05 Jun 2023
Historique:
received: 25 03 2023
revised: 18 05 2023
accepted: 22 05 2023
medline: 28 6 2023
pubmed: 28 6 2023
entrez: 28 6 2023
Statut: epublish

Résumé

Beta-lactamase (β-lactamase)-producing Gram-negative bacteria (GNB) are of public health concern due to their resistance to routine antimicrobials. We investigated the antimicrobial resistance and occurrence of carbapenemases, extended-spectrum β-lactamases (ESBLs) and AmpCs among GNB from clinical sources. GNB were identified using matrix-assisted laser desorption/ionization time of flight-mass spectrometry (MALDITOF-MS). Antimicrobial susceptibility testing was performed via Kirby-Bauer disk diffusion and a microscan autoSCAN system. β-lactamase genes were determined via multiplex polymerase chain reactions. Of the 181 archived GNB analyzed,

Identifiants

pubmed: 37370334
pii: antibiotics12061016
doi: 10.3390/antibiotics12061016
pmc: PMC10295373
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Carnegie Cor-poration of New York
ID : RY89 Caprex project

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Auteurs

Felicia A Owusu (FA)

Department of Bacteriology, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra 00233, Ghana.

Noah Obeng-Nkrumah (N)

Department of Medical Laboratory Sciences, School of Biomedical and Allied Health Sciences, University of Ghana, Accra 00233, Ghana.

Esther Gyinae (E)

Department of Microbiology, Korle-Bu Teaching Hospital, Accra 00233, Ghana.

Sarkodie Kodom (S)

University of Ghana Hospital, Accra 00233, Ghana.

Rhodalyn Tagoe (R)

Department of Bacteriology, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra 00233, Ghana.

Blessing Kofi Adu Tabi (BKA)

Department of Bacteriology, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra 00233, Ghana.

Nicholas T K D Dayie (NTKD)

Department of Medical Microbiology, University of Ghana Medical School, University of Ghana, Accra 00233, Ghana.

Japheth A Opintan (JA)

Department of Medical Microbiology, University of Ghana Medical School, University of Ghana, Accra 00233, Ghana.

Beverly Egyir (B)

Department of Bacteriology, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra 00233, Ghana.

Classifications MeSH