The Role of Multimodal Imaging in Pathological Response Prediction of Locally Advanced Cervical Cancer Patients Treated by Chemoradiation Therapy Followed by Radical Surgery.
18F-FDG-PET/CT
cervical cancer
chemoradiation
magnetic resonance imaging
pathological response prediction
ultrasound
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
06 Jun 2023
06 Jun 2023
Historique:
received:
16
03
2023
revised:
18
05
2023
accepted:
02
06
2023
medline:
28
6
2023
pubmed:
28
6
2023
entrez:
28
6
2023
Statut:
epublish
Résumé
This study aimed to develop predictive models for pathological residual disease after neoadjuvant chemoradiation (CRT) in locally advanced cervical cancer (LACC) by integrating parameters derived from transvaginal ultrasound, MRI and PET/CT imaging at different time points and time intervals. Patients with histologically proven LACC, stage IB2-IVA, were prospectively enrolled. For each patient, the three examinations were performed before, 2 and 5 weeks after treatment ("baseline", "early" and "final", respectively). Multivariable logistic regression models to predict complete vs. partial pathological response (pR) were developed and a cost analysis was performed. Between October 2010 and June 2014, 88 patients were included. Complete or partial pR was found in 45.5% and 54.5% of patients, respectively. The two most clinically useful models in pR prediction were (1) using percentage variation of SUV The percentage variation in SUV
Identifiants
pubmed: 37370682
pii: cancers15123071
doi: 10.3390/cancers15123071
pmc: PMC10296350
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Eur J Cancer. 2009 Jan;45(2):228-47
pubmed: 19097774
Eur J Nucl Med Mol Imaging. 2018 Nov;45(12):2139-2146
pubmed: 30069578
Int J Gynecol Pathol. 2008 Apr;27(2):274-81
pubmed: 18317212
Ultrasound Obstet Gynecol. 2012 Feb;39(2):226-34
pubmed: 21845741
Gynecol Oncol. 2006 Sep;102(3):523-9
pubmed: 16504274
Eur J Nucl Med Mol Imaging. 2020 May;47(5):1228-1238
pubmed: 31414206
Acta Obstet Gynecol Scand. 2004 Jun;83(6):591-7
pubmed: 15144343
J Natl Cancer Inst. 1999 Mar 17;91(6):500-1
pubmed: 10088618
Gynecol Oncol. 2020 Jun;157(3):639-643
pubmed: 32248993
Ultrasound Obstet Gynecol. 2000 Oct;16(5):500-5
pubmed: 11169340
Eur J Radiol. 2014 Jul;83(7):1169-1176
pubmed: 24767630
Oncologist. 2010;15(4):405-15
pubmed: 20332143
Gynecol Oncol. 2006 Feb;100(2):338-43
pubmed: 16213008
Br J Radiol. 2021 Sep 1;94(1125):20201342
pubmed: 33989030
Radiographics. 2020 Oct;40(6):1807-1822
pubmed: 32946322
Ann Oncol. 2013 Aug;24(8):2043-7
pubmed: 23609186
Br J Radiol. 2017 Jul;90(1075):20170035
pubmed: 28508679
Eur Radiol. 2018 Jun;28(6):2425-2435
pubmed: 29318432
Radiology. 2017 Aug;284(2):432-442
pubmed: 28301309
Int J Radiat Oncol Biol Phys. 2014 Nov 15;90(4):778-85
pubmed: 25585781
Am J Clin Oncol. 2017 Jun;40(3):250-255
pubmed: 27028351
Ultrasound Obstet Gynecol. 1997 Jan;9(1):49-52
pubmed: 9060131
Gynecol Oncol. 2010 Dec;119(3):404-10
pubmed: 20817228
Int J Med Inform. 2018 Aug;116:10-17
pubmed: 29887230
Eur Radiol. 2019 Apr;29(4):2045-2057
pubmed: 30324389
Magn Reson Imaging. 2014 May;32(4):342-9
pubmed: 24512795
Ultrasound Obstet Gynecol. 2018 Jul;52(1):110-118
pubmed: 29119649
Ultrasound Med Biol. 1999 Sep;25(7):1041-5
pubmed: 10574335
Cochrane Database Syst Rev. 2010 Jan 20;(1):CD008285
pubmed: 20091664
Int J Gynecol Cancer. 2016 Mar;26(3):534-8
pubmed: 26745701
Int J Gynecol Cancer. 2010 Feb;20(2):268-75
pubmed: 20169670
Int J Radiat Oncol Biol Phys. 2012 Mar 1;82(3):1164-71
pubmed: 21531085
Int J Gynaecol Obstet. 2009 May;105(2):103-4
pubmed: 19367689
Ultrasound Obstet Gynecol. 2018 May;51(5):684-695
pubmed: 28620930
Cancer. 2007 Oct 15;110(8):1738-44
pubmed: 17786947