3D Organoids for Regenerative Endodontics.
cell interactions
in vitro models
organoids
regenerative endodontics
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
28 05 2023
28 05 2023
Historique:
received:
25
03
2023
revised:
19
05
2023
accepted:
23
05
2023
medline:
29
6
2023
pubmed:
28
6
2023
entrez:
28
6
2023
Statut:
epublish
Résumé
Apical periodontitis is the inflammation and destruction of periradicular tissues, mediated by microbial factors originating from the infected pulp space. This bacteria-mediated inflammatory disease is known to interfere with root development in immature permanent teeth. Current research on interventions in immature teeth has been dedicated to facilitating the continuation of root development as well as regenerating the dentin-pulp complex, but the fundamental knowledge on the cellular interactions and the role of periapical mediators in apical periodontitis in immature roots that govern the disease process and post-treatment healing is limited. The limitations in 2D monolayer cell culture have a substantial role in the existing limitations of understanding cell-to-cell interactions in the pulpal and periapical tissues. Three-dimensional (3D) tissue constructs with two or more different cell populations are a better physiological representation of in vivo environment. These systems allow the high-throughput testing of multi-cell interactions and can be applied to study the interactions between stem cells and immune cells, including the role of mediators/cytokines in simulated environments. Well-designed 3D models are critical for understanding cellular functions and interactions in disease and healing processes for future therapeutic optimization in regenerative endodontics. This narrative review covers the fundamentals of (1) the disease process of apical periodontitis; (2) the influence and challenges of regeneration in immature roots; (3) the introduction of and crosstalk between mesenchymal stem cells and macrophages; (4) 3D cell culture techniques and their applications for studying cellular interactions in the pulpal and periapical tissues; (5) current investigations on cellular interactions in regenerative endodontics; and, lastly, (6) the dental-pulp organoid developed for regenerative endodontics.
Identifiants
pubmed: 37371480
pii: biom13060900
doi: 10.3390/biom13060900
pmc: PMC10296151
pii:
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Références
Nat Med. 2009 Jan;15(1):42-9
pubmed: 19098906
PeerJ. 2020 Apr 24;8:e8970
pubmed: 32355576
J Endod. 2017 Sep;43(9S):S31-S34
pubmed: 28781092
Cell Stem Cell. 2008 Feb 7;2(2):141-50
pubmed: 18371435
J Exp Med. 1994 Nov 1;180(5):1587-90
pubmed: 7964446
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001 Aug;92(2):221-7
pubmed: 11505271
Front Bioeng Biotechnol. 2020 Aug 04;8:911
pubmed: 32850750
Front Pharmacol. 2020 Jan 24;10:1576
pubmed: 32038250
Int Endod J. 2003 Jul;36(7):464-71
pubmed: 12823701
J Prosthodont Res. 2012 Jul;56(3):151-65
pubmed: 22796367
J Periodontal Res. 1989 May;24(3):207-13
pubmed: 2550604
J Endod. 1991 Jan;17(1):26-9
pubmed: 1895036
J Endod. 2008 Feb;34(2):166-71
pubmed: 18215674
Crit Rev Oral Biol Med. 2004 Nov 01;15(6):348-81
pubmed: 15574679
J Endod. 2014 Mar;40(3):333-8
pubmed: 24565648
PLoS One. 2010 Feb 16;5(2):e9252
pubmed: 20169081
Front Pharmacol. 2018 Jan 23;9:6
pubmed: 29410625
Int Arch Allergy Appl Immunol. 1991;94(1-4):110-5
pubmed: 1657790
J Am Dent Assoc. 2016 May;147(5):372-80
pubmed: 27017182
J Endod. 2014 Feb;40(2):192-8
pubmed: 24461403
J Endod. 2022 Jun;48(6):741-748
pubmed: 35245579
Tissue Eng Regen Med. 2019 Sep 12;16(5):513-523
pubmed: 31624706
Tissue Eng Part C Methods. 2012 Feb;18(2):81-9
pubmed: 21913838
J Endod. 1996 Jun;22(6):311-6
pubmed: 8934992
Int Endod J. 2020 Jun;53(6):859-870
pubmed: 32068891
Tissue Eng Part C Methods. 2018 Feb;24(2):108-120
pubmed: 29298406
J Clin Med. 2020 Jan 16;9(1):
pubmed: 31963371
Eur J Immunol. 2007 Nov;37 Suppl 1:S9-17
pubmed: 17972350
Front Mol Biosci. 2020 Mar 06;7:33
pubmed: 32211418
J Pers Med. 2021 Jun 09;11(6):
pubmed: 34207600
Biol Blood Marrow Transplant. 2017 Jun;23(6):861-862
pubmed: 28396165
J Pathol. 2013 Jan;229(2):176-85
pubmed: 23096265
J Cell Biochem. 2016 Jul;117(7):1511-21
pubmed: 26442636
Transplant Res. 2012 Sep 28;1(1):12
pubmed: 23369493
J Endod. 2013 Nov;39(11):1416-22
pubmed: 24139265
J Endod. 2018 Jul;44(7):1126-1131
pubmed: 29884336
Biomedicines. 2022 Aug 17;10(8):
pubmed: 36009546
Acta Biomater. 2019 Jul 1;92:172-183
pubmed: 31085365
Braz Dent J. 2011;22(2):91-8
pubmed: 21537580
J Endod. 2017 Apr;43(4):561-567
pubmed: 28190588
Bone Res. 2018 Jan 31;6:2
pubmed: 29423331
Cells. 2020 Mar 06;9(3):
pubmed: 32155898
Exp Cell Res. 2014 Jan 1;320(1):92-107
pubmed: 24162002
World J Stem Cells. 2014 Nov 26;6(5):552-70
pubmed: 25426252
Oral Microbiol Immunol. 1995 Aug;10(4):213-9
pubmed: 8602333
J Dent Res. 2018 Sep;97(10):1137-1143
pubmed: 29702010
J Endod. 2017 Jun;43(6):916-922
pubmed: 28416302
J Endod. 2021 Jun;47(6):961-969
pubmed: 33775732
Arch Oral Biol. 2018 Jul;91:1-8
pubmed: 29621667
PLoS One. 2013;8(3):e59482
pubmed: 23527204
Trends Cell Biol. 2011 Dec;21(12):745-54
pubmed: 22033488
J Dent Res. 2020 May;99(5):523-529
pubmed: 32202965
J Immunol Res. 2015;2015:394917
pubmed: 25961059
Cell Stem Cell. 2008 Jun 5;2(6):566-75
pubmed: 18522849
Stem Cell Res Ther. 2019 Nov 26;10(1):345
pubmed: 31771622
Endod Dent Traumatol. 1992 Apr;8(2):45-55
pubmed: 1521505
Tissue Eng Part A. 2010 Oct;16(10):3023-31
pubmed: 20486799
Semin Nephrol. 2010 May;30(3):216-33
pubmed: 20620668
J Endod. 2017 Nov;43(11):1821-1827
pubmed: 28864219
J Endod. 2022 Apr;48(4):430-456
pubmed: 35032538
Front Immunol. 2014 May 19;5:148
pubmed: 24904568
PLoS One. 2008 May 21;3(5):e2258
pubmed: 18493609
J Endod. 1981 Mar;7(3):117-22
pubmed: 6938631
J Endod. 2008 Jun;34(6):645-51
pubmed: 18498881
J Endod. 2019 May;45(5):560-566
pubmed: 30935618
Bone Joint Res. 2019 Nov 02;8(10):481-488
pubmed: 31728188
Int J Mol Sci. 2015 Mar 11;16(3):5517-27
pubmed: 25768338
Cancer Surv. 1992;12:81-103
pubmed: 1638549
J Immunol. 1987 Mar 1;138(5):1464-8
pubmed: 3492553
J Endod. 2018 Mar;44(3):464-469
pubmed: 29254817
Physiology (Bethesda). 2017 Jul;32(4):266-277
pubmed: 28615311
Tissue Eng Part B Rev. 2008 Mar;14(1):61-86
pubmed: 18454635
J Endod. 2015 Jun;41(6):817-23
pubmed: 25771141
Clin Oral Investig. 2018 Jan;22(1):385-394
pubmed: 28501945
Trends Immunol. 2004 Dec;25(12):677-86
pubmed: 15530839
Assay Drug Dev Technol. 2014 May;12(4):207-18
pubmed: 24831787
Endod Dent Traumatol. 1994 Jun;10(3):121-8
pubmed: 7995240
Dent Clin North Am. 2010 Apr;54(2):313-24
pubmed: 20433980
J Immunol. 1986 Dec 1;137(11):3544-9
pubmed: 3097126
Oral Microbiol Immunol. 2000 Jun;15(3):139-50
pubmed: 11154396
Appl Microbiol Biotechnol. 2015 Jan;99(2):623-36
pubmed: 25432676
J Endod. 2008 Jul;34(7 Suppl):S51-6
pubmed: 18565373
J Diabetes Investig. 2016 Jul;7(4):485-96
pubmed: 27181261
Front Cell Dev Biol. 2021 Feb 05;8:609204
pubmed: 33634100
J Cell Mol Med. 2021 Mar;25(5):2390-2403
pubmed: 33511706
J Dent Res. 2016 Oct;95(11):1274-81
pubmed: 27384335
Clin Plast Surg. 1994 Jul;21(3):429-35
pubmed: 7924141
J Orthop Res. 1991 Sep;9(5):641-50
pubmed: 1870029
PLoS One. 2013;8(3):e59689
pubmed: 23555746
J Endod. 2013 Aug;39(8):1078-83
pubmed: 23880282
J Immunol. 2006 Nov 15;177(10):7303-11
pubmed: 17082649
Biomed Res Int. 2019 Jan 29;2019:6104738
pubmed: 30834270
Biotechnol Bioeng. 2009 Jul 1;103(4):655-63
pubmed: 19472329
Int Endod J. 2022 Jan;55(1):79-88
pubmed: 34587308
Arch Oral Biol. 1990;35(5):387-95
pubmed: 1695503
SLAS Discov. 2019 Jul;24(6):615-627
pubmed: 30817892
J Endod. 2020 Apr;46(4):502-508
pubmed: 32088011
J Endod. 2016 Nov;42(11):1626-1632
pubmed: 27639638
J Endod. 2019 Aug;45(8):977-984.e1
pubmed: 31248698
Cell Tissue Res. 2006 Jun;324(3):411-22
pubmed: 16489443
Front Cell Dev Biol. 2021 Jun 25;9:681171
pubmed: 34249933
Oral Surg Oral Med Oral Pathol. 1965 Sep;20:340-9
pubmed: 14342926
Biochem Biophys Res Commun. 1990 Nov 15;172(3):1035-41
pubmed: 2244889
Front Biosci. 2008 Jan 01;13:453-61
pubmed: 17981560
Cell Mol Immunol. 2019 Dec;16(12):908-920
pubmed: 30778166
J Tissue Eng Regen Med. 2019 May;13(5):785-798
pubmed: 30771241
J Endod. 2017 Sep;43(9S):S95-S101
pubmed: 28844309
Science. 2014 Jul 18;345(6194):1247125
pubmed: 25035496
Tissue Eng Regen Med. 2017 Jun 27;14(4):393-401
pubmed: 30603495
J Cell Biol. 2017 Jan 2;216(1):31-40
pubmed: 28031422
J Endod. 2022 Aug;48(8):1063-1072.e7
pubmed: 35513088
Eur J Histochem. 2010 Nov 10;54(4):e46
pubmed: 21263745
Transplant Proc. 2011 Dec;43(10):3955-9
pubmed: 22172878
J R Soc Interface. 2014 Jul 6;11(96):
pubmed: 24829281
Gynecol Oncol. 2009 Apr;113(1):143-8
pubmed: 19135710
Microbiol Rev. 1996 Jun;60(2):316-41
pubmed: 8801436
Endod Dent Traumatol. 2000 Feb;16(1):1-8
pubmed: 11202850
J Endod. 2016 Sep;42(9):1362-70
pubmed: 27451120
Cell Mol Life Sci. 2018 Aug;75(15):2843-2856
pubmed: 29417177
Jpn Dent Sci Rev. 2018 Aug;54(3):105-117
pubmed: 30128058
Arch Oral Biol. 2013 Oct;58(10):1556-68
pubmed: 23871383
Arthritis Rheum. 2009 Mar;60(3):813-23
pubmed: 19248097
Stem Cells. 2012 Apr;30(4):762-72
pubmed: 22267310
Drug Discov Today. 2002 Jun 1;7(11):612-20
pubmed: 12047872
J Endod. 2013 Jan;39(1):138-44
pubmed: 23228274
Sci Rep. 2019 Sep 30;9(1):14015
pubmed: 31570730
J Periodontal Res. 1999 Jan;34(1):16-24
pubmed: 10086882
J Clin Invest. 2012 Mar;122(3):787-95
pubmed: 22378047
Tissue Eng Part A. 2015 Mar;21(5-6):1163-72
pubmed: 25380198
Front Immunol. 2014 Nov 28;5:614
pubmed: 25506346
PLoS One. 2006 Dec 20;1:e79
pubmed: 17183711
Interface Focus. 2019 Aug 6;9(4):20180089
pubmed: 31263531
J Dent. 2017 Jan;56:19-32
pubmed: 27744048
Age Ageing. 1997 Dec;26 Suppl 4:15-9
pubmed: 9506428
Int J Dev Biol. 1994 Sep;38(3):405-20
pubmed: 7848824
Clin Oral Investig. 2020 Dec;24(12):4571-4581
pubmed: 32444919
Endocrinology. 1995 Jun;136(6):2752-9
pubmed: 7750500
Biomaterials. 2019 Mar;196:80-89
pubmed: 29329642
Arch Oral Biol. 2014 Mar;59(3):310-7
pubmed: 24581854
Crit Rev Oral Biol Med. 1998;9(4):498-521
pubmed: 9825224
Nat Immunol. 2010 Oct;11(10):889-96
pubmed: 20856220
Biomaterials. 2015 Mar;44:11-23
pubmed: 25617122
Int Endod J. 2019 Dec;52(12):1758-1767
pubmed: 31378943
J Endod. 2017 Nov;43(11):1835-1840
pubmed: 28822568
J Endod. 2012 Apr;38(4):454-63
pubmed: 22414829
Front Immunol. 2019 Apr 15;10:792
pubmed: 31037072
Cells Tissues Organs. 2010;191(5):357-64
pubmed: 20090301
Cell Immunol. 1990 Mar;126(1):47-56
pubmed: 2302741
Dent Mater. 2023 Apr;39(4):333-349
pubmed: 36894414
Mol Ther. 2015 Nov;23(11):1783-1793
pubmed: 26216515
Pharmacol Rev. 2009 Jun;61(2):198-223
pubmed: 19549927
Cell Signal. 2020 Feb;66:109487
pubmed: 31778739
Curr Opin Biotechnol. 2013 Oct;24(5):830-3
pubmed: 23726156
Int Endod J. 2016 Oct;49(10):950-9
pubmed: 26383494
J Endod. 2007 Apr;33(4):377-90
pubmed: 17368324
Folia Histochem Cytobiol. 2006;44(4):215-30
pubmed: 17219716