Application of Inositol Hexaphosphate and Inositol in Dental Medicine: An Overview.
clinical observations
molecular interactions
periodontitis
phytic acid
resolution of inflammation
tissue repair
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
31 05 2023
31 05 2023
Historique:
received:
20
04
2023
revised:
23
05
2023
accepted:
29
05
2023
medline:
29
6
2023
pubmed:
28
6
2023
entrez:
28
6
2023
Statut:
epublish
Résumé
Phosphorylated inositol hexaphosphate (IP6) is a naturally occurring carbohydrate, and its parent compound, myoinositol (Ins), is abundantly present in plants, particularly in certain high-fiber diets, but also in mammalian cells, where they regulate essential cellular functions. IP6 has profound modulation effects on macrophages, which warrants further research on the therapeutic benefits of IP6 for inflammatory diseases. Here, we review IP6 as a promising compound that has the potential to be used in various areas of dentistry, including endodontics, restorative dentistry, implantology, and oral hygiene products, due to its unique structure and characteristic properties. Available as a dietary supplement, IP6 + Ins has been shown to enhance the anti-inflammatory effect associated with preventing and suppressing the progression of chronic dental inflammatory diseases. IP6 in dentistry is now substantial, and this narrative review presents and discusses the different applications proposed in the literature and gives insights into future use of IP6 in the fields of orthodontics, periodontics, implants, and pediatric dentistry.
Identifiants
pubmed: 37371493
pii: biom13060913
doi: 10.3390/biom13060913
pmc: PMC10296266
pii:
doi:
Substances chimiques
Inositol
4L6452S749
Phytic Acid
7IGF0S7R8I
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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