Identification of a Favorable Prognostic Subgroup in Oral Squamous Cell Carcinoma: Characterization of ITGB4/PD-L1
CD8
ITGB4
PD-1/PD-L1 axis
oral squamous cell carcinoma
prognosis
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
19 06 2023
19 06 2023
Historique:
received:
18
03
2023
revised:
25
05
2023
accepted:
13
06
2023
medline:
29
6
2023
pubmed:
28
6
2023
entrez:
28
6
2023
Statut:
epublish
Résumé
Integrin β4 (ITGB4) is a member of the integrin family, which plays a crucial role in mediating cell adhesion to the extracellular matrix. Recent studies have demonstrated that ITGB4 is involved in tumorigenesis and metastasis during the development of cancer. However, the role of ITGB4 in oral squamous cell carcinoma (OSCC) remains unclear. A Multiplex immunohistochemistry (OPAL™, mIHC) assay was employed to stain ITGB4, ALDH1, PD-L1, cytokeratin (CK), CD8 and PD-1 in a human OSCC tissue microarray, containing 26 normal oral epithelium samples, 21 oral epithelium dysplasia samples and 76 OSCC samples. The expression pattern and clinicopathological characteristics of ITGB4 were analyzed and compared with those of PD-1, PD-L1, ALDH1 and CD8. The correlation between subgroups of tumor cells, including ITGB4
Identifiants
pubmed: 37371594
pii: biom13061014
doi: 10.3390/biom13061014
pmc: PMC10296360
pii:
doi:
Substances chimiques
B7-H1 Antigen
0
Integrin beta4
0
Programmed Cell Death 1 Receptor
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Références
Cancer Res. 1995 Nov 15;55(22):5434-44
pubmed: 7585613
N Engl J Med. 2016 Nov 10;375(19):1856-1867
pubmed: 27718784
Br J Cancer. 1993 Sep;68(3):507-14
pubmed: 8353041
Toxicol Appl Pharmacol. 2008 Jan 15;226(2):178-91
pubmed: 17961621
FEBS Lett. 2016 Jun;590(12):1826-37
pubmed: 27178753
Blood. 2009 Aug 20;114(8):1537-44
pubmed: 19423728
Sci Rep. 2015 Jul 30;5:12642
pubmed: 26223322
Nat Rev Dis Primers. 2020 Nov 26;6(1):92
pubmed: 33243986
Oncogene. 2005 Oct 13;24(45):6820-9
pubmed: 16007143
Gut. 1992 Mar;33(3):342-6
pubmed: 1568652
Lancet Oncol. 2016 Jul;17(7):956-965
pubmed: 27247226
Cell. 1992 Apr 3;69(1):11-25
pubmed: 1555235
Nat Rev Cancer. 2020 Nov;20(11):662-680
pubmed: 32753728
Medicine (Baltimore). 2016 Sep;95(1 Suppl 1):S20-S25
pubmed: 27611935
Proc Soc Exp Biol Med. 1999 Nov;222(2):124-38
pubmed: 10564536
J Cancer. 2021 Aug 24;12(20):6118-6125
pubmed: 34539884
J Pathol. 1998 May;185(1):44-52
pubmed: 9713359
Oncogene. 2022 Jul;41(30):3804-3820
pubmed: 35773413
Oral Oncol. 2019 Mar;90:115-121
pubmed: 30846169
Science. 2006 Sep 29;313(5795):1960-4
pubmed: 17008531
Gastroenterology. 2000 Mar;118(3):497-506
pubmed: 10702200
Proc Natl Acad Sci U S A. 2019 Apr 9;116(15):7353-7362
pubmed: 30910979
CA Cancer J Clin. 2022 Jan;72(1):7-33
pubmed: 35020204
Curr Opin Cell Biol. 2001 Oct;13(5):541-5
pubmed: 11544021
J Clin Invest. 2013 Feb;123(2):682-99
pubmed: 23348745
Cell Stem Cell. 2007 Nov;1(5):555-67
pubmed: 18371393
Oral Oncol. 2020 Dec;111:104931
pubmed: 32736208
Lancet. 2019 Nov 23;394(10212):1915-1928
pubmed: 31679945
Cell. 2006 Aug 11;126(3):489-502
pubmed: 16901783
Int J Gen Med. 2021 Dec 11;14:9629-9645
pubmed: 34924769
Cell. 2002 Sep 20;110(6):673-87
pubmed: 12297042
Lab Invest. 2015 Sep;95(9):976-86
pubmed: 26121317
Br J Cancer. 1990 Apr;61(4):636-8
pubmed: 2158810
PLoS One. 2014 Nov 14;9(11):e109026
pubmed: 25398092
J Biol Chem. 2013 Jan 25;288(4):2191-200
pubmed: 23212923
Semin Cancer Biol. 2017 Jun;44:10-24
pubmed: 28257956
Cells. 2022 Feb 25;11(5):
pubmed: 35269423
Biochem Cell Biol. 1996;74(6):811-21
pubmed: 9164650
Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):E2337-E2346
pubmed: 28270621
Oral Oncol. 2016 Aug;59:30-42
pubmed: 27424180
Semin Cancer Biol. 2001 Apr;11(2):129-41
pubmed: 11322832
Clin Cancer Res. 2004 Jun 1;10(11):3755-62
pubmed: 15173082
Front Immunol. 2022 Sep 02;13:988416
pubmed: 36119046
J Cell Biol. 2002 Jul 8;158(1):165-74
pubmed: 12105188
Cancer. 1996 Apr 1;77(7):1303-10
pubmed: 8608507