G Protein-Coupled Receptors and the Rise of Type 2 Diabetes in Children.
GPCRs
diabetes in youth
glucose homeostasis
type 2 diabetes
β cells
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
29 May 2023
29 May 2023
Historique:
received:
11
05
2023
revised:
26
05
2023
accepted:
27
05
2023
medline:
28
6
2023
pubmed:
28
6
2023
entrez:
28
6
2023
Statut:
epublish
Résumé
The human genome counts hundreds of GPCRs specialized to sense thousands of different extracellular cues, including light, odorants and nutrients in addition to hormones. Primordial GPCRs were likely glucose transporters that became sensors to monitor the abundance of nutrients and direct the cell to switch from aerobic metabolism to fermentation. Human β cells express multiple GPCRs that contribute to regulate glucose homeostasis, cooperating with many others expressed by a variety of cell types and tissues. These GPCRs are intensely studied as pharmacological targets to treat type 2 diabetes in adults. The dramatic rise of type 2 diabetes incidence in pediatric age is likely correlated to the rapidly evolving lifestyle of children and adolescents of the new century. Current pharmacological treatments are based on therapies designed for adults, while youth and puberty are characterized by a different hormonal balance related to glucose metabolism. This review focuses on GPCRs functional traits that are relevant for β cells function, with an emphasis on aspects that could help to differentiate new treatments specifically addressed to young type 2 diabetes patients.
Identifiants
pubmed: 37371671
pii: biomedicines11061576
doi: 10.3390/biomedicines11061576
pmc: PMC10295181
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
Nat Commun. 2023 Jan 18;14(1):301
pubmed: 36653347
Mol Metab. 2021 Jul;49:101181
pubmed: 33556643
Int J Mol Sci. 2021 Jan 09;22(2):
pubmed: 33435513
ACS Med Chem Lett. 2022 Nov 02;13(12):1839-1847
pubmed: 36518697
Diabetes Care. 2022 Aug 1;45(8):1833-1840
pubmed: 35679098
Mol Pharmacol. 2017 Sep;92(3):201-210
pubmed: 28246190
Diabetes Obes Metab. 2022 Jul;24(7):1380-1384
pubmed: 35491535
Appl Physiol Nutr Metab. 2015 Nov;40(11):1089-99
pubmed: 26466085
Children (Basel). 2023 Mar 05;10(3):
pubmed: 36980074
Bioessays. 2014 Aug;36(8):778-87
pubmed: 24903552
Diabetes Care. 2013 Aug;36 Suppl 2:S175-9
pubmed: 23882043
Sci Signal. 2018 Aug 28;11(545):
pubmed: 30154102
Eur J Pharmacol. 2019 Jul 15;855:267-275
pubmed: 31078517
Int J Mol Sci. 2019 Apr 27;20(9):
pubmed: 31035572
Int J Mol Sci. 2014 Dec 26;16(1):378-400
pubmed: 25548896
Diabetologia. 2012 Nov;55(11):2878-94
pubmed: 22933123
Nat Commun. 2016 Jul 11;7:11756
pubmed: 27399229
FEMS Yeast Res. 2018 Aug 1;18(5):
pubmed: 29788060
J Clin Invest. 2017 Oct 2;127(10):3835-3844
pubmed: 28920919
Curr Diab Rep. 2016 Jul;16(7):64
pubmed: 27179965
Mol Biol Evol. 2009 Nov;26(11):2407-14
pubmed: 19651853
Int J Mol Sci. 2022 Oct 13;23(20):
pubmed: 36293091
Cells. 2019 Oct 09;8(10):
pubmed: 31600876
Am J Physiol Regul Integr Comp Physiol. 2011 Jun;300(6):R1266-77
pubmed: 21411768
Biomolecules. 2022 Sep 22;12(10):
pubmed: 36291552
Diabetol Metab Syndr. 2020 Apr 8;12:30
pubmed: 32280378
Front Biosci (Landmark Ed). 2011 Jan 01;16(1):251-60
pubmed: 21196169
Eur J Endocrinol. 2022 Mar 23;186(5):523-533
pubmed: 35225824
Nat Commun. 2022 Jan 24;13(1):454
pubmed: 35075127
Nat Rev Genet. 2023 Jan;24(1):4-20
pubmed: 36028773
Br J Pharmacol. 2022 Feb;179(4):492-510
pubmed: 33880754
BMJ. 2022 Dec 7;379:e072385
pubmed: 36740855
J Photochem Photobiol B. 2023 Jan;238:112617
pubmed: 36495671
Mol Metab. 2018 Jan;7:90-101
pubmed: 29167062
J Biol Chem. 2003 Jul 11;278(28):25481-9
pubmed: 12711604
Curr Opin Pharmacol. 2013 Dec;13(6):954-8
pubmed: 24064396
Am J Physiol Endocrinol Metab. 2004 Aug;287(2):E199-206
pubmed: 15271645
Metabolism. 2019 Jul;96:46-55
pubmed: 31029770
Trends Endocrinol Metab. 2020 Mar;31(3):192-204
pubmed: 31901302
Front Physiol. 2021 Apr 07;12:656441
pubmed: 33897464
Int J Occup Med Environ Health. 2010;23(3):287-91
pubmed: 20934953
J Clin Endocrinol Metab. 2021 May 13;106(6):1718-1727
pubmed: 33596309
J Pineal Res. 2008 Oct;45(3):318-27
pubmed: 18363673
J Biol Chem. 2003 Mar 28;278(13):11312-9
pubmed: 12496283
Nat Rev Endocrinol. 2019 Feb;15(2):90-104
pubmed: 30446744
Diabetes Care. 2021 Jul;44(7):1573-1578
pubmed: 34099516
N Engl J Med. 2017 Apr 13;376(15):1419-1429
pubmed: 28402773
Diabetes Care. 2012 Dec;35(12):2515-20
pubmed: 23173134
Pharmacol Res Perspect. 2022 Oct;10(5):e01013
pubmed: 36177761
Diabetes. 2012 Sep;61(9):2205-13
pubmed: 22751699
J Biol Chem. 2001 Apr 20;276(16):13096-103
pubmed: 11150299
Mol Metab. 2014 Oct 24;4(1):3-14
pubmed: 25685685
Brain Disord Ther. 2014;4(1):
pubmed: 25705578
Mol Cell Endocrinol. 2009 Jan 15;297(1-2):50-7
pubmed: 18602447
Pediatr Diabetes. 2019 Aug;20(5):538-548
pubmed: 31074070
Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2222-6
pubmed: 9482866
N Engl J Med. 2022 Jul 21;387(3):205-216
pubmed: 35658024
Pediatr Neurol. 2002 May;26(5):379-82
pubmed: 12057799
Mol Metab. 2016 Dec 21;6(2):185-193
pubmed: 28180060
J Pediatr Pharmacol Ther. 2021;26(1):4-20
pubmed: 33424495
Nutr Metab (Lond). 2016 Dec 9;13:92
pubmed: 27990172
Front Endocrinol (Lausanne). 2021 Aug 06;12:722250
pubmed: 34421829
Children (Basel). 2023 Jan 25;10(2):
pubmed: 36832337
Diabetes. 2022 Jul 1;71(7):1454-1471
pubmed: 35472681
Birth Defects Res. 2017 Dec 1;109(20):1659-1671
pubmed: 29251845
Trends Endocrinol Metab. 2013 Aug;24(8):398-407
pubmed: 23631851
Diabetes Care. 2023 May 1;46(5):998-1004
pubmed: 36857477
Front Endocrinol (Lausanne). 2022 Oct 27;13:1043650
pubmed: 36387846
Adv Exp Med Biol. 2017;960:19-52
pubmed: 28585194
North Clin Istanb. 2018 May 29;5(4):295-301
pubmed: 30859159
Diabetes Care. 2023 Jan 1;46(Suppl 1):S19-S40
pubmed: 36507649
J Biol Chem. 2013 Feb 15;288(7):4513-21
pubmed: 23269670
Diabetes Obes Metab. 2015 Sep;17(9):878-86
pubmed: 26094857
Nat Commun. 2018 Mar 13;9(1):1050
pubmed: 29535304
J Bone Miner Res. 2011 Jul;26(7):1680-3
pubmed: 21425331
Physiol Behav. 2009 Jul 14;97(5):551-60
pubmed: 19328819
Physiol Rev. 2007 Oct;87(4):1409-39
pubmed: 17928588
J Cell Mol Med. 2017 May;21(5):1024-1032
pubmed: 27957792
N Engl J Med. 2019 Aug 15;381(7):637-646
pubmed: 31034184
Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):E7997-E8006
pubmed: 28874589
Diabetes Obes Metab. 2017 Dec;19(12):1714-1721
pubmed: 28493502
Diabetes. 2008 Sep;57(9):2280-7
pubmed: 18519800
Nutr Metab Cardiovasc Dis. 2019 Jun;29(6):561-571
pubmed: 31078362
NEJM Evid. 2022 Jun;1(6):
pubmed: 36968652
Auton Neurosci. 2004 Jan 30;110(1):36-43
pubmed: 14766323
Cell Rep. 2015 Aug 4;12(5):726-33
pubmed: 26212334
JCI Insight. 2022 Nov 8;7(21):
pubmed: 36107617
Ann N Y Acad Sci. 2017 Mar;1391(1):20-34
pubmed: 27750377
Curr Top Behav Neurosci. 2012;11:1-24
pubmed: 22016109
Diabetologia. 2017 Jul;60(7):1333-1343
pubmed: 28374068
J Clin Invest. 2005 May;115(5):1111-9
pubmed: 15864338
Ann Pediatr Endocrinol Metab. 2020 Dec;25(4):217-226
pubmed: 33401880
Endocrinology. 2007 Oct;148(10):4965-73
pubmed: 17584962
BMC Psychiatry. 2019 Nov 29;19(1):356
pubmed: 31779637
Exp Gerontol. 2004 Nov-Dec;39(11-12):1723-9
pubmed: 15582288
Obesity (Silver Spring). 2015 Oct;23(10):2075-82
pubmed: 26331843
BMJ Open Diabetes Res Care. 2020 Jul;8(1):
pubmed: 32690574
Pharmacol Res. 2022 Oct;184:106411
pubmed: 36007775
Arch Endocrinol Metab. 2015 Oct;59(5):391-9
pubmed: 26331226
Nature. 2021 Jan;589(7843):620-626
pubmed: 33408414
Exp Mol Med. 2014 Jun 20;46:e102
pubmed: 24946790
Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2888-93
pubmed: 25695968
Horm Metab Res. 2004 Nov-Dec;36(11-12):811-21
pubmed: 15655713
Dialogues Clin Neurosci. 2002 Mar;4(1):57-72
pubmed: 22034091
Nature. 2021 Feb;590(7845):326-331
pubmed: 33505018
Adv Pediatr. 2016 Aug;63(1):403-28
pubmed: 27426909
J Med Chem. 2021 Apr 22;64(8):4312-4332
pubmed: 33843223
Front Cell Neurosci. 2021 Oct 07;15:725296
pubmed: 34690701
Rev Endocr Metab Disord. 2022 Feb;23(1):111-120
pubmed: 34195966
Cell Signal. 2014 Nov;26(11):2412-23
pubmed: 25038452
Front Endocrinol (Lausanne). 2022 Nov 16;13:1061524
pubmed: 36465645
Biomed Res. 2009 Jun;30(3):149-56
pubmed: 19574715
Pediatr Diabetes. 2011 Jun;12(4 Pt 1):302-6
pubmed: 21129138